A possible correlation between low serum vitamin-D levels and type 2 diabetes mellitus

Abstract

Background: Diabetes Mellitus is a metabolic disease which continues to be a major public health concern. Vitamin D deficiency has been found to be associated with Diabetes Mellitus, decreased Insulin secretion and increased insulin resistance in animals and humans. Recent Research is now beginning to uncover the role of vitamin D in pancreatic beta cell function, Insulin action and inflammation. The beta cells of pancreas possess Vitamin D receptors and the enzyme 1 alpha Hydroxylase is expressed in pancreatic tissue which coincides with the expression of Insulin. Insulin secretion is calcium dependent and it is reported that vitamin D deficiency impairs glucose mediated insulin release. Aim & Objective: The main of the current study to evaluate serum Vitamin D Levels in newly diagnosed Type 2 Diabetes Mellitus patients. Methodology: The study was conducted on 50 newly diagnosed Type 2 Diabetes Mellitus patients attending the outpatient department of Dr. VRK Women Medical College, Hospital and Research center, Hyderabad. Glycemic status was estimated by measuring FBS, PLBS and HbA1c levels. 25(OH) Vitamin D estimation, by HPLC method, was done to estimate vitamin D levels. Results: The mean 25(OH) Vitamin D levels in Diabetic patients were 8.05 ±1.5 whereas the mean serum 25(OH) Vitamin D concentration in the control group was 34.28 ±13.42.Our study showed significantly lower levels of Vitamin D in Type 2 Diabetes Mellitus patients than in the control group. Also there was an inverse relation between HbA1c and Vitamin D levels which also emphasizes that those diabetics with Vitamin D deficiency had higher HbA1c levels. Conclusion: Vitamin D appears to play a role in blood glucose regulation and low levels of Vitamin D may be a risk factor in development of Type 2 Diabetes Mellitus. There might be a beneficial effect in supplementation of Vitamin D to improve glycemic control in patients with Type 2 Diabetes Mellitus.

Serum levels of vitamin D, calcium, phosphorus, and oxidative parameters in healthy and diabetic people

“…After conducting this study, we detected that the level of vitamin D in the T2DM group, compared to the healthy group, was significantly lower. It can be concluded that there is a role for vitamin D in regulating blood sugar and improving insulin sensitivity by reducing insulin resistance [1]. This study correlates well with the study conducted by weeks, once a week, cheese with and without vitamin D were given to subjects that were randomly divided into two groups of 28,000 IU of vitamin D3 (VitD; n = 35) and placebo (n = 36).…”

“…Vitamin D can play a role in keeping extracellular calcium levels normal, thereby controlling the flow of calcium through the cell membrane. Decreased serum vitamin D levels can affect and reduce the ability of calcium to secrete insulin [1]. In our study, serum calcium and phosphorus levels did not show a statistical significant difference with the control group.…”

“…Previous studies suggested that receptors of Vitamin D are located within pancreatic beta cells, and adequate levels of vitamin D aids insulin sensitivity and insulin secretion [8,9]. Moreover, vitamin D is involved in calcium regulation and through this role, it can indirectly affect insulin release from pancreatic beta cells [1]. samples, and genetic polymorphism (at least for vitamin D receptor), the results have shown that vitamin D and calcium do not play a protective role in T2DM [11].…”

“…Type 2 diabetes mellitus (T2DM) is characterized by a chronic rise in blood sugar due to a relative lack of insulin, insulin resistance, or both. Diabetes and its late effects lead to reduced life expectancy and health costs [1]. T2DM has become one of the most momentous and common health problems in recent decades and is now the 7th leading cause of death in the United States as well as worldwide with 5.2 million deaths.…”

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

“…Recent studies have investigated the possible involvement of vitamin D in the pathogenesis of diabetes and its related complication [7,8]. This fat-soluble vitamin's receptor has been discovered in pancreatic beta cells, implicating a possible function in insulin secretion [7,8]. Furthermore, insulin sensitivity and function have been linked to serum vitamin D levels [7].…”