Cultural-Historical Psychology, developed by Lev S. Vygotsky, is a complex theory which responds to contemporary clinical needs, since it considers social relations and subjectivity as a historical process. This experience report aims to point out the clinical paths built and carried out with a patient from the Applied Psychology Service (APS) of a public university in the state of Ceará, during a Cultural-Historical psychotherapy process. All ethical procedures were followed and this study was based on a qualitative perspective in psychology, and also, case study was used as a methodological approach, considering that it allows greater detail and deepening about the studied object. From the studied case and the interventions carried out by the psychologist, changes were noticed in both the patient’s subjective dynamics and his way of life, as a result of the psychotherapeutic mediation on the mentioned approach. Thus, the present article is among the few clinical studies about Cultural-Historical Psychology, adding up to the greater promotion and production in this field.