A randomized, controlled, single-blinded, multicenter evaluation of the efficacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa

Abstract

BackgroundOtitis externa is a common problem in small animal practice. Compliance with daily treatment is a major cause of treatment failure. The hypothesis tested is that a novel otic gel applied to the ear canal twice with a one-week interval is as efficacious as a daily otic suspension in the treatment of canine otitis externa. The study included 286 privately owned dogs with otitis externa.In this single blinded randomized study, enrolled dogs received either an otic gel containing 1% florfenicol, 1% terbinafine and 0.1% betamethasone acetate twice with a one-week interval or a suspension containing hydrocortisone aceponate, miconazole and gentamicin daily for 5 days. Ears were cleaned with saline prior to administration of the first dose of medication. Dogs were evaluated at day (D) 0, 7, 28 and 56 with an otitis index score (OTIS-3), otic culture and cytology, pain and pruritus, and overall response to treatment (owner and investigator evaluation). Outcome measures were improvement of the OTIS-3 and number of dogs in clinical remission at each time point.ResultsOTIS-3 decreased significantly (p < 0.0001) by 63 and 64% for the otic gel and by 63 and 61% for the suspension on D28 and D56 respectively. There was no significant difference between groups at any time point with regard to clinical success, pain, pruritus, overall assessments or otic cytology and culture. The treatment response was considered excellent or good by approximately three quarters of both the clinicians and Owners. Otitis recurrence at D56 was seen in 11% of both groups. Adverse events attributable to the ear medications were not noted.ConclusionsAdministering an otic gel twice at a one-week interval is an effective, safe and convenient way to treat canine otitis externa.

Malassezia otitis unresponsive to primary care: outcome in 59 dogs

“…Almost 60 years later, despite the development of multiple new ear products, this statement is still valid. Intervention trials with topical therapeutics for unspecified OE have reported success rates between 65% and 81% 9,10,20–22 . The potential for chronic disease is highlighted by a report that 24% of dogs presenting for otitis had one or multiple recurrences following initial treatment with topical combination products 23 .…”

“…However, the authors regularly encounter cases of chronic (persistent or recurrent) otitis in their canine referral caseload, with Malassezia as the only identifiable pathogen, based on cytological results from aural discharge alone or in combination with negative aerobic or anaerobic bacterial culture. As the sole pathogen, Malassezia has been identified in 8% and 26% of OE cases 9,10 …”

Management of otitis externa with an led-illuminated gel: a randomized controlled clinical trial in dogs

“…Daily application of topical ear formulations in dogs at home is often difficult to perform leading to stress for both pets and owners and often poor treatment compliance [10,17,54]. A recent study has shown that reducing the frequency of otitis treatment can improve pets and owners quality of life [17].…”

Experience of using the ear gel «Osurnia» in dogs with otitis externa

“…Несмотря на большое число препаратов в виде капель для контроля микробной инфекции, владельцы часто обеспокоены тем, что вынуждены использовать топикальные средства ежедневно [3]. Тем более, большинство собак с хроническим отитом проявляют выраженное беспокойство при попытке провести санацию и ввести препарат в слуховые проходы.…”

“…Поэтому подбор субстанций для эффективной терапии инфекции, особенно резистентной [4], очень актуален. Была раз-работана и опробована клиницистами инновационная форма геля, содержащего тербинафин, бетаметазон и флорфеникол, для которой достаточно двукратного применения с интервалом 1 неделя [3].…”