A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and<i>N</i>-alkylated chitosan

Chen, Zihao; Lei, Han; Liu, Changjun; Du, Yu; Hu, Xiao; Du, Ge; Shan, Chao; Yang, Kun; Wang, Chunlai; Li, Minggao; Li, Fan; Tian, Faming

doi:10.1039/c8nr07865c

Cited by 80 publications

(44 citation statements)

References 43 publications

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“…Both hemostatic and analgesic features may be attributed to the positive charge of chitosan. Given the fact that the red blood cells are negatively charged, they can interact with cationic chitosan molecules; therefore, chitosan’s hemostatic effect relies on electrostatic adhesion to blood cells [137]. The exact hemostatic mechanism of chitosan is yet to be fully understood, but theories rely on plasma sorption, erythrocyte coagulation, and platelet activation and aggregation [138].…”

Section: Chitosan Interaction With Eukaryotic Cellsmentioning

confidence: 99%

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Matica

Aachmann

Tøndervik

et al. 2019

IJMS

541

275

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Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.

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Section: Chitosan Interaction With Eukaryotic Cellsmentioning

confidence: 99%

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Matica

Aachmann

Tøndervik

et al. 2019

IJMS

541

275

View full text Add to dashboard Cite

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“…The viscoelastic changes to blood upon adding the samples were then evaluated primarily by assessing TEG parameters such as reaction time ( R ), K value, angle (α), and maximum amplitude (MA; Figure 5G). [ 45 ] Esterification reaction modified the surface of MS with high negative potential, resulting in a huge reduction in the R and K values (Table S1, Supporting Information), and a sharp increase in α and MA values for MSS, MSST, and Janus MSS@CaCO 3 T, indicating their short blood clotting time and high blood clotting strength. Additionally, MSST and Janus MSS@CaCO 3 T showed lower R and K values and higher α and MA, likely due to the assembled thrombin.…”

Section: Resultsmentioning

confidence: 99%

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

et al. 2020

Adv Funct Materials

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Achieving rapid and safe control of perforating and irregular hemorrhage, defined as bleeding wounds with irregular external and internal wound shape, located deep within complex and covert hemorrhage sites, is vital to decrease the risk of mortality during prehospital treatments and surgical procedures. However, current hemostatic materials do not control hemorrhage effectively as their ability to access the bleeding source and coagulate blood is limited. Here, a biphasic Janus self-propelled hemostatic particle (MSS@CaCO 3) is prepared via uniaxial growth of flower-like calcium carbonate crystal (CaCO 3) on negatively-modified-microporous starch (MSS). The as-synthesized hemostatic particle (MSS@CaCO 3 T) is loaded with thrombin and powered by the internal component CaCO 3, with the collaborative use of protonated tranexamic acid. These particles are capable of traveling against the blood flow allowing them to access deep bleeding sites, inducing synergistic blood coagulation effects to effectively halt hemorrhaging. The self-propelling Janus hemostatic particle is sufficiently available in the deep bleeding sites of liver and femoral artery hemorrhage models, wherein the hemorrhage is rapidly controlled in ≈50 s and ≈3 min, respectively. To the authors' knowledge, this is the first attempt of controlling hemorrhage using Janus hemostatic particles with a self-propelling property.

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“…In vitro platelet gathering was determined by a lactate dehydrogenase (LDH) assay . Before measurement, SD rat blood samples were collected in tubes containing 3.8% sodium citrate at a 9:1 blood:citrate ratio, and platelet‐rich plasma was obtained by centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Anti‐Adhesive, Platelet Gathering Effects of c‐RGD Modified Poly(p‐dioxanone‐co‐l‐Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis

Wang

Feng

Dang

et al. 2019

Macromolecular Bioscience

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d-Phe of cRGD and l-Phe of PDPA. Although cRGD modification enhanced the biocompatibility of PDPA membranes, cRGD modified PDPA membrane suppresses fibroblast proliferation both in vitro and in vivo as a result of degradation and subsequent release of fibroblast suppressive l-Phe from PDPA. Meanwhile, platelets are entrapped by cRGD modified PDPA membranes through the specific binding of cRGD and platelet GP IIbIIIa . cRGD modified PDPA membranes are applied in rat intestinal anastomosis, and both adhesion and stenosis are successfully prevented at anastomotic sites. At the same time, bursting pressure, which represents healing intensity at anastomotic sites, is promoted. The gathering and activation of platelets on PDPA membranes induce secretion of autologous PDGF and VEGF to facilitate angiogenesis and subsequent healing of anastomotic sites.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.

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A rapid hemostatic sponge based on large, mesoporous silica nanoparticles andN-alkylated chitosan

Abstract:
Due to the designed, coagulation-promoting microstructure, a rapid and safe hemostat was developed and its hemostatic efficiency was evaluated by in vitro clotting tests and in vivo hemostatic analyses.

Cited by 80 publications

References 43 publications

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

Anti‐Adhesive, Platelet Gathering Effects of c‐RGD Modified Poly(p‐dioxanone‐co‐l‐Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis

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A rapid hemostatic sponge based on large, mesoporous silica nanoparticles andN-alkylated chitosan

Abstract: Due to the designed, coagulation-promoting microstructure, a rapid and safe hemostat was developed and its hemostatic efficiency was evaluated by in vitro clotting tests and in vivo hemostatic analyses.

Cited by 80 publications

References 43 publications

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

Anti‐Adhesive, Platelet Gathering Effects of c‐RGD Modified Poly(p‐dioxanone‐co‐l‐Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis

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Product

Resources

About

Abstract:
Due to the designed, coagulation-promoting microstructure, a rapid and safe hemostat was developed and its hemostatic efficiency was evaluated by in vitro clotting tests and in vivo hemostatic analyses.