A review on mushroom-derived bioactive peptides: Preparation and biological activities

Zhou, Juanjuan; Chen, Mengfei; Wu, Shujian; Liao, Xiyu; Wang, Juan; Wu, Qingping; Zhuang, Mingzhu; Ding, Yu

doi:10.1016/j.foodres.2020.109230

Cited by 85 publications

(71 citation statements)

References 131 publications

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“…Soy protein, which usually represents approximately 40% of the seed content, is degraded into peptides by microbial proteases during fermentation. The peptides produced from soy proteins exhibit various beneficial effects, including antioxidant activity, which regulate the redox balance in the gut and subsequently influence the gut microbiota in a positive manner [139,140].…”

Section: Gut Microbiota and Pdmentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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Fermented soybean products, such as cheonggukjang (Japanese natto), doenjang (soy paste), ganjang (soy sauce), and douchi, are widely consumed in East Asian countries and are major sources of bioactive compounds. The fermentation of cooked soybean with bacteria (Bacillus spp.) and fungi (Aspergillus spp. and Rhizopus spp.) produces a variety of novel compounds, most of which possess health benefits. This review is focused on the preventive and ameliorative potential of fermented soy foods and their components to manage neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases.

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Section: Gut Microbiota and Pdmentioning

confidence: 99%

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang

Lim

et al. 2021

Foods

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“…A good number of procedures and techniques such as gel filtration-coupled high performance liquid chromatography-tandem mass spectrometry (HPLC-MS), liquid chromatography-mass spectrometry (LC-MS), ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-ESI-MS/MS), ultrasound, matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS), ion exchange chromatography and reversed-phase high performance liquid chromatography-tandem ultrafast liquid chromatography (RP-HPLC UFLC) [ 60 , 61 ] are currently being explored for the isolation, identification and quantification of peptides from protein hydrolysates. For more information on the preparation and quantification of peptides from proteins, see previous reviews [ 62 , 63 , 64 , 65 , 66 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

et al. 2021

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There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of Lupinus species (Lupin), a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties. This paper discusses the intestinal transport, bioavailability and biological activities of LDPs, focusing on molecular mechanisms of action as reported in in vitro, cell culture, animal and human studies. The potentials of several LDPs to demonstrate multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, and antioxidant and anti-inflammatory activities position LDPs as good candidates for nutraceutical development for the prevention and management of medical conditions whose etiology are multifactorial.

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“…Regarding the protein sources of bioactive peptides, one of the promising foodstuffs are mushrooms [13]. Firstly, the average protein content in mushrooms is about 23.80 ± 9.82 g/100 g dry weight [14], which is higher than most vegetables. Mushrooms are also rich in various bioactive compounds, such as polysaccharides, phenols, peptides, carotenoids, ergosterol, and vitamins C and E [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Antioxidant Protein Hydrolysates from Pleurotus geesteranus and Their Protective Effects on H2O2 Oxidative Damaged PC12 Cells

Liao

Zhu

et al. 2020

Molecules

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Pleurotus geesteranus is a promising source of bioactive compounds. However, knowledge of the antioxidant behaviors of P. geesteranus protein hydrolysates (PGPHs) is limited. In this study, PGPHs were prepared with papain, alcalase, flavourzyme, pepsin, and pancreatin, respectively. The antioxidant properties and cytoprotective effects against oxidative stress of PGPHs were investigated using different chemical assays and H2O2 damaged PC12 cells, respectively. The results showed that PGPHs exhibited superior antioxidant activity. Especially, hydrolysate generated by alcalase displayed the strongest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (91.62%), 2,2-azino-bis (3-ethylbenzothia zoline-6-sulfonic acid) (ABTS) radical scavenging activity (90.53%), ferric reducing antioxidant power, and metal ion-chelating activity (82.16%). Analysis of amino acid composition revealed that this hydrolysate was rich in hydrophobic, negatively charged, and aromatic amino acids, contributing to its superior antioxidant properties. Additionally, alcalase hydrolysate showed cytoprotective effects on H2O2-induced oxidative stress in PC12 cells via diminishing intracellular reactive oxygen species (ROS) accumulation by stimulating antioxidant enzyme activities. Taken together, alcalase hydrolysate of P. geesteranus protein can be used as beneficial ingredients with antioxidant properties and protective effects against ROS-mediated oxidative stress.

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A review on mushroom-derived bioactive peptides: Preparation and biological activities

Cited by 85 publications

References 131 publications

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

Preparation of Antioxidant Protein Hydrolysates from Pleurotus geesteranus and Their Protective Effects on H2O2 Oxidative Damaged PC12 Cells

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