A ruthenium(IV) disulfide based non-enzymatic sensor for selective and sensitive amperometric determination of dopamine

Deepika, Jain; Sha, Rinky; Badhulika, Sushmee

doi:10.1007/s00604-019-3622-3

Cited by 36 publications

(18 citation statements)

References 37 publications

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“…Therefore, the low detection limit and high sensitivity revealed by the ruthenium electrode can be explained by the high porosity of this material. The recorded electrocatalytic parameters of the Ru electrode were compared with several electrode materials that were used for dopamine enzymeless sensing [36,[45][46][47][48][49] (Table 3). We also tested the selectivity of the Ru-based microelectrode in the presence of a number of interfering substances, such as ascorbic acid (AA), urea (UA), and D-glucose (Glu).…”

Section: Resultsmentioning

confidence: 99%

“…In the current study, we manufactured a ruthenium-based microelectrode to detect dopamine concentration. Materials containing ruthenium are widely known and are used as enzyme-free sensors [29][30][31][32][33][34][35][36]. For example, porous ruthenium oxide (RuO 2 ) is used to catalyze glucose and hydrogen peroxide, as well as to measure pH [30].…”

Section: Introductionmentioning

confidence: 99%

“…This usefulness is due to the fact that RuO 2 exhibits high sensitivity, good electrocatalytic activity, outstanding thermal stability, and high corrosion resistance. In addition, it was recently shown that ruthenium disulfide (RuS 2 ) demonstrates high sensitivity with respect to dopamine detection due to its great stability, electronic configuration nature, availability of catalytic active sites, and superb electrochemical redox characteristics [36]. Thus, as a main part of this work, we developed a sensor platform based on ruthenium microstructures with good selectivity, decent stability, and high sensitivity to the non-enzymatic determination of dopamine.…”

Section: Introductionmentioning

confidence: 99%

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In Situ Laser-Induced Fabrication of a Ruthenium-Based Microelectrode for Non-Enzymatic Dopamine Sensing

et al. 2020

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In this paper, we propose a fast and simple approach for the fabrication of the electrocatalytically active ruthenium-containing microstructures using a laser-induced metal deposition technique. The results of scanning electron microscopy and electrical impedance spectroscopy (EIS) demonstrate that the fabricated ruthenium-based microelectrode had a highly developed surface composed of 10 μm pores and 10 nm zigzag cracks. The fabricated material exhibited excellent electrochemical properties toward non-enzymatic dopamine sensing, including high sensitivity (858.5 and 509.1 μA mM−1 cm−2), a low detection limit (0.13 and 0.15 μM), as well as good selectivity and stability.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Situ Laser-Induced Fabrication of a Ruthenium-Based Microelectrode for Non-Enzymatic Dopamine Sensing

et al. 2020

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“…Therefore, total CA concentration can effectively be measured without the use of redox mediators and/or enzymes. The direct oxidation of DA, EP, and NEP on different electrode platforms allowed for the development of several sensors for CA detection [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. However, these sensors suffer from relatively high oxidation potential and electrode surface passivation values due to the electrogenerated phenoxy radicals [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Amperometric Biosensor Based on Tyrosinase/Chitosan Nanoparticles for Sensitive and Interference-Free Detection of Total Catecholamine

et al. 2022

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The regulation of nervous and cardiovascular systems and some brain-related behaviors, such as stress, panic, anxiety, and depression, are strictly dependent on the levels of the main catecholamines of clinical interest, dopamine (DA), epinephrine (EP), and norepinephrine (NEP). Therefore, there is an urgent need for a reliable sensing device able to accurately monitor them in biological fluids for early diagnosis of the diseases related to their abnormal levels. In this paper, we present the first tyrosinase (Tyr)-based biosensor based on chitosan nanoparticles (ChitNPs) for total catecholamine (CA) detection in human urine samples. ChitNPs were synthetized according to an ionic gelation process and successively characterized by SEM and EDX techniques. The screen-printed graphene electrode was prepared by a two-step drop-casting method of: (i) ChitNPS; and (ii) Tyr enzyme. Optimization of the electrochemical platform was performed in terms of the loading method of Tyr on ChitNPs (nanoprecipitation and layer-by-layer), enzyme concentration, and enzyme immobilization with and without 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as cross-linking agents. The Tyr/EDC-NHS/ChitNPs nanocomposite showed good conductivity and biocompatibility with Tyr enzyme, as evidenced by its high biocatalytic activity toward the oxidation of DA, EP, and NEP to the relative o-quinone derivatives electrochemically reduced at the modified electrode. The resulting Tyr/EDC-NHS/ChitNPs-based biosensor performs interference-free total catecholamine detection, expressed as a DA concentration, with a very low LOD of 0.17 μM, an excellent sensitivity of 0.583 μA μM−1 cm−2, good stability, and a fast response time (3 s). The performance of the biosensor was successively assessed in human urine samples, showing satisfactory results and, thus, demonstrating the feasibility of the proposed biosensor for analyzing total CA in physiological samples.

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“…The normal DA concentration in human blood is in the range 0.01–1 µM [ 3 , 4 ]. The extremely low levels of dopamine increase the risk of neurological diseases such as Parkinson’s disease, Schizophrenia, Tourette’s syndrome, Alzheimer’s disease, Huntington’s disease, hypertension and attention deficit hyperactivity disorder [ 4 , 5 , 6 ]. It is; therefore, necessary to detect DA in low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

2021

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Dopamine (DA) is an important neurotransmitter which indicates the risk of several neurological diseases. The selective determination with low detection limit is necessary for early diagnosis and prevention of neurological diseases associated with abnormal concentration of DA. The purpose of this study is to fabricate a poly(3-aminobenzylamine)/poly(sodium 4-styrenesulfonate) (PABA/PSS) multilayer thin film for use as an electrochemical DA biosensor. The PABA was firstly synthesized using a chemical oxidation method of 3-aminobenzylamine (ABA) monomer with ammonium persulfate (APS) as an oxidant. For electrochemical biosensor, the PABA/PSS thin film was fabricated on fluorine doped tin oxide (FTO)-coated glass substrate using the layer-by-layer (LBL) self-assembly method. The optimized number of bilayers was achieved using SEM and cyclic voltammetry (CV) results. The electroactivity of the optimized LBL thin film toward detection of DA in neutral solution was studied by CV and amperometry. The PABA/PSS thin film showed good sensitivity for DA sensing with sensitivity of 6.922 nA.cm−2.µM−1 and linear range of 0.1–1.0 µM (R2 = 0.9934), with low detection limit of 0.0628 µM, long-term stability and good reproducibility. In addition, the selectivity of the PABA/PSS thin film for detection of DA under the common interferences (i.e., ascorbic acid, uric acid and glucose) was also presented. The prepared PABA/PSS thin film showed the powerful efficiency for future use as DA biosensor in real sample analysis.

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A ruthenium(IV) disulfide based non-enzymatic sensor for selective and sensitive amperometric determination of dopamine

Cited by 36 publications

References 37 publications

In Situ Laser-Induced Fabrication of a Ruthenium-Based Microelectrode for Non-Enzymatic Dopamine Sensing

In Situ Laser-Induced Fabrication of a Ruthenium-Based Microelectrode for Non-Enzymatic Dopamine Sensing

Novel Amperometric Biosensor Based on Tyrosinase/Chitosan Nanoparticles for Sensitive and Interference-Free Detection of Total Catecholamine

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

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