A Simplified CFD for Three-dimensional Analysis of Fluid Mixing, Mass Transfer and Bioreaction in a Fermenter Equipped with Triple Novel Geometry Impellers

High-throughput system for screening of Monascus purpureus high-yield strain in pigment production

“…Many papers published the simulation methods of mixing [21], mass transfer [22], and shear environment [23] in different kinds of stirred tanks. The fluid dynamics of 24-, 48-, and 96-deep MTPs and 500-mL shake flask were studied respectively using the CFD tool ANSYS CFX 11.0 to get better understanding of their turbulent regimes.…”

Mathematical modeling of production and biorefinery of energy crops

“…Table 6 gives the values of K and n as a function of the concentration of total solids in sewage sludge. (38) A similar CFD technique has also been used to simulate the mixing and hydrodynamic characteristics of a gas-liquid-solid multiple phase flow in bioreactors to improve their design and operation [57][58][59]. model.…”

Applicability of GFP Microbial Whole Cell Biosensors to Bioreactor Operations - Mathematical Modeling and Related Experimental Tools

“…The NOZ model is based on the same physical and mathematical principles than for the compartment model, but in this case the number of virtual fluid zones has been significantly increased, allowing a higher spatial discretization of the bioreactor domain. NOZ models comprising up to 36,000 fluid zones have been used (Hristov H.V., 2004) and have allowed to capture to some extent the complex liquid or gas-liquid flow patterns in stirred or pneumatically agitated bioreactors (Hristov H.V., 2004, Zahradnik J., 2001, Mann R., 1997. However, the elaboration of NOZ models is based on some prior knowledge, such as the streamlines pattern (Hristov H.V., 2004), which is difficult to obtain for complex turbulent flow.…”

“…NOZ models comprising up to 36,000 fluid zones have been used (Hristov H.V., 2004) and have allowed to capture to some extent the complex liquid or gas-liquid flow patterns in stirred or pneumatically agitated bioreactors (Hristov H.V., 2004, Zahradnik J., 2001, Mann R., 1997. However, the elaboration of NOZ models is based on some prior knowledge, such as the streamlines pattern (Hristov H.V., 2004), which is difficult to obtain for complex turbulent flow. A second limitation is the hypothesis that all the circulation flows between the fluid zones have the same intensities, which can leads to the abstraction of local stagnant zones that can have a detrimental effect at the level of the bioprocess.…”