A spectrofluorimetric determination of phenothiazine derivatives after their photooxidation or chemical or electrochemical oxidation in a flow injection arrangement

Nesměrák, Karel; Červený, Vlastislav; Hraníček, Jakub; Rychlovský, Petr

doi:10.1016/j.microc.2012.07.006

Cited by 14 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the second step, the radical cation is irreversibly oxidized by loss of another electron and PTZ ion is created (not shown in Scheme 2). This ion is consequently hydrolyzed, resulting in production of a colorless sulfoxide [49,50]. In this research work the peak of second oxidation step was chosen at about 0.5V for removing detection and quantitative analysis of PTZ in DPV technique (Fig.…”

Section: Electrochemical Behavior Of Ptzmentioning

confidence: 99%

“…Due to very low solubility of PTZ in water, removing of template from the cavities of MIP decreased. On the other hand, it is supposed that the rate of second reaction step strongly depends on the rate of consequent hydrolysis [49], so reduction of current is justifiable in volumes of less than 40%H 2 O. According to peak current efficiency, 60 % (v/v) ACN/H 2 O was selected for preparation of BR buffer in DPV experiments.…”

Section: The Solvent Effectmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Nezhadali

Rouki

Nezhadali

2015

Talanta

View full text Add to dashboard Cite

Section: Electrochemical Behavior Of Ptzmentioning

confidence: 99%

Section: The Solvent Effectmentioning

confidence: 99%

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Nezhadali

Rouki

Nezhadali

2015

Talanta

View full text Add to dashboard Cite

“…The increasing use of phenothiazine derivatives in medicine has boosted the development of several methods for their determination in pure form and in pharmaceutical formulations. The methods used for their determination include spectrofluorometry [5,6], conductometry [7], fluoroimmunoassay [8], HPLC [9,10], HPTLC [11] polarography [12], GLC [13], chemiluminescence [14], and capillary zone electrophoresis [15]. The official methods presented in the British pharmacopoeia for phenothiazines consist of nonaqueous potentiometric titrimetry or spectrophotometry in the ultraviolet region, depending upon the derivative [5].…”

mentioning

confidence: 99%

Sensitive spectrophotometric method for determination of some phenothiazine drugs

Upadhyay¹,

Asthana²,

Tamrakar

2014

Res Chem Intermed

View full text Add to dashboard Cite

A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05-4.0, 0.02-2.0, 0.05-5.0, 0.1-8.0, and 0.05-2.0 lg mL -1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.

show abstract

Facile, eco‐friendly and sensitive fluorimetric approach for detection of chlorpromazine: Application in biological fluids and tablet formulations as well as greenness evaluation of the analytical method

Mostafa,

Mohamed,

Alahmadi

et al. 2024

Luminescence

View full text Add to dashboard Cite

Monitoring antipsychotic drugs in biological fluids, such as human serum and urine, is important for ensuring the safety and efficacy of psychiatric treatments. This process helps maintain therapeutic drug levels, minimize side effects, and optimize patient well‐being. Chlorpromazine (CZ) is a widely prescribed antipsychotic drug used for conditions like schizophrenia, bipolar disorder, and acute psychosis. Almost all existing sensing techniques for CZ are either insensitive spectrophotometric methods or involve long and complex chromatographic procedures, limiting their routine use. In this work, we introduce a facile, green, and sensitive fluorimetric strategy with high reproducibility for detecting CZ in its pure form, tablet formulation, and spiked human plasma and urine without the need for derivatization reactions. The proposed method relies on the inhibition of the intramolecular photoinduced electron transfer (PET) effect by using 2.0 M acetic acid. This approach enables the linear detection of CZ from 3.0 to 600 ng/mL with remarkably low quantitation and detection limits of 1.51 and 0.49 ng/mL, respectively. Moreover, the developed method's greenness was evaluated.

show abstract

A spectrofluorimetric determination of phenothiazine derivatives after their photooxidation or chemical or electrochemical oxidation in a flow injection arrangement

Cited by 14 publications

References 21 publications

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

Sensitive spectrophotometric method for determination of some phenothiazine drugs

Facile, eco‐friendly and sensitive fluorimetric approach for detection of chlorpromazine: Application in biological fluids and tablet formulations as well as greenness evaluation of the analytical method

Contact Info

Product

Resources

About