A Study of Lipid Profile in Prediabetes

Kumar, Manoj; Singh, Prem Shankar; Zafar, Khwaja Saifullah; Kumar, Granth

doi:10.18410/jebmh/2016/489

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Evaluation of the serum lipid parameters showed an elevation of total cholesterol, LDL cholesterol and serum triglycerides above normal limits even in the control group which comprised of obese normo-glycemic individuals. This lends weightage to studies carried out by Franssen R, et al [4] and Wang H, et al [5] . Who studied the impact of obesity on triglycerides and concluded that there is a positive correlation between these entities.…”

Section: Discussionsupporting

confidence: 61%

Study of serum lipid profile in obese prediabetics

Subhramanyam¹

2020

Int. J. Adv. Res. Med.

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Prediabetes is well-known to be a significant risk factor for type 2diabetes as well as heart disease and other chronic conditions. The pattern of multi-system involvement in prediabetes is similar to that of diabetic neuropathy. The purpose of this study was to determine the trend in fasting lipids in obese prediabetics who were obese at baseline. Objective of the study:To study the serum lipid profile in prediabetic patients who are obese. Materials and Methods:This study is a prospective case control study including 100 cases and 100 controls admitted to Shadan Institute of Medical Sciences, Hyderabad over a period of 18 months meeting the selection criteria. The relevant data was collected and the variables were analyzed using t test and chi square tests. Results:The study evaluated 100 cases and 100 controls meeting the selection criteria. The mean age among the control group was 43 years, and it was 47.27 years in the case/study group. The body mass index (BMI) had a mean value of 29.4kg/m 2 in the control group and averaged 28.09kg/m 2 in the case group. The fasting blood sugar averaged 93 in the control group and had a mean value of 111.68 in the case group. The p value was <0.001 and was significant. The HbA1c used for defining patients of interest had a mean of 5.26 in the control group as against 6.06 among the case group, p value being significant at <0.001.Among 100 controls, 58 were females and 42 were males. In comparison, there were 46 females and 54 males in the case group. There were 44 subjects below the age of 45(inclusive) and 56 subjects who were above 45 years among the cases while the control group had 60 individuals who were more than 45 years of age and 40 individuals aged 45 years or less. Analysis did not show any statistically significant elevation in lipid parameters as far as age and gender delineation was concerned. It was also observed that HbA1c by itself was not an adequate tool for identifying dyslipidemia when compared to FBS. Conclusion:This study concluded that serum lipid parameters are significantly elevated in prediabetic obese individuals barring HDL-c which is decreased. These prediabetic obese individuals because of their dyslipidemic status are at a higher risk for developing cardiovascular disease.

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Section: Discussionsupporting

confidence: 61%

Study of serum lipid profile in obese prediabetics

Subhramanyam¹

2020

Int. J. Adv. Res. Med.

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“…15 About 5-10% of pre-diabetic patient become diabetic annually and nearly 70 % of pre-diabetics eventually develop diabetes mellitus if not treated in early stage. 16 Macro and micro vascular complications can start in IGT and early detection and treatment of dyslipidemia in IGT will decrease the risk of cardiovascular diseases (CVD). 15 Fasting blood glucose (FBG), post prandial blood glucose (PPBG) and glycated hemoglobin (HbA1c) are most widely used as glycemic control markers.…”

Section: Introductionmentioning

confidence: 99%

“…But very few studies are done in IGT in this regard. 15,16 . Thus, the aim of this study was to find comparison and correlation between FBG, PPBG andHbA1cwith lipid profile in T2DM patients and IGT.…”

Section: Introductionmentioning

confidence: 99%

“…A study done in Saifai by Kumar et al on pre-diabetics showed TC, TGL, LDL were significantly more than normal controls and HDL was significantly decreased in prediabetics compared to controls. 16 Dyslipidemia in IGT patients indicated high risk category for cardiovascular diseases. 15 Regarding correlation of glycemic control markers and lipid parameters between IGT and control group, we could not find any references to the best of our literature search.…”

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confidence: 99%

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Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

et al. 2018

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Background: Many studies have compared and correlated glycemic control markers with lipid profile in type 2 diabetes mellitus (T2DM) patients, but very few studies correlate them in impaired glucose tolerance (IGT) individuals. Thus, the aim of this study was to find comparison and correlation between FBG, PPBG and HbA1c with lipid profile in T2DM patients and IGT individuals.Methods: The study was conducted at tertiary care hospital in north Karnataka. The diagnosis of T2DM and IGT was based on WHO criteria. 99 apparently healthy controls, 101 T2DM patients and 100 IGT subjects participated in the study.Results: All the biochemical parameters were significantly raised in IGT and T2DM patients as compared to controls.In T2DM, FBG showed significant positive correlation with TC (p=0.048) and significant negative correlation with HDL (p=0.000). PPBG and HbA1c showed significant positive correlation with TGL, TC VLDL and LDL and significant negative correlation with HDL, p value was 0.000 for all parameters. The correlation in IGT, FBG showed significant positive correlation with TC (p=0.000) and LDL (p=0.004), significant negative correlation with HDL (p=0.000). PPBG showed significant positive correlation with TGL, TC and VLDL and significant negative correlation with HDL(p=0.000).Conclusions: Diagnosis of T2DM, IGT and associated dyslipidema is necessary as life style modification and pharmacotherapy can control these situations and thereby reduce the cardiovascular risk.

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“…Meanwhile, people's job plays a fundamental role in their daily physical activity, in which it has been reported that office employees spend 66 to 82% of their time inactive and almost 75% in seated positions, which lead to increased risk of obesity and its related diseases, such as diabetes, non-alcoholic fatty liver disease, and cardiovascular disease [4][5][6][7].Also, Corresponding author: Mohsen Parvani, Master student of physical education and sport science faculty of Allameh Tabataba'I University, research fields: Exercise physiology.…”

Section: Introduction mentioning

confidence: 99%

Lipid Profile and Hepatic Enzymes Differences between Pre-diabetes and Normal Staff

Kushkestani¹,

Parvani²,

Nosrani³

et al. 2020

JSS

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Purpose:The aim of this study was to investigate lipid profile and hepatic enzymes difference between pre-diabetes and normal subjects.Methods:In this cross-sectional study, 264 employees of Energy Industries Engineering & Design (EIED) Company were randomly selected and participated in the study in January 2019.A sample of 10 mL of venous blood was obtained between 8 a.m. and 10 a.m. Blood analyses for fasting glucose (FG), total cholesterol (TC), triglyceride (TG), LDL-cholesterol, HDL-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were determined by enzymatic methods. Body composition and anthropometric indices were measured and recorded using the OMRON BF511 device and tape measure.Achievements of This Study:TG, the LDL/HDL ratio, and the ALT were significantly higher in the pre-diabetes group. Also, body mass index, waist circumference, waist-hip ratio were significantly higher in pre-diabetic women than in normoglycemic women.According to the results of this study suggested that the risk of cardiovascular and liver diseases in people with pre-diabetes increases and the intervention of lifestyle such as increased levels of physical activity and exercise to prevent diabetes and related complications.

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A Study of Lipid Profile in Prediabetes

Cited by 5 publications

References 17 publications

Study of serum lipid profile in obese prediabetics

Study of serum lipid profile in obese prediabetics

Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

Lipid Profile and Hepatic Enzymes Differences between Pre-diabetes and Normal Staff

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