A study of the mechanical strength of long bone defects treated with various bone autograft substitutes: An experimental investigation in the rabbit

Hopp, Stanley G.; Dahners, Laurence E.; Gilbert, John E.

doi:10.1002/jor.1100070416

Cited by 76 publications

(47 citation statements)

References 25 publications

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“…They designed an experiment in which the ulnar defects of rats were grafted by HA, DBM, HA/DBM, autogenous bone graft and allogenic bone graft in five different groups. At the sixth week, they found that the plain HA group scored worse than the control group, whereas all other groups displayed better scores [12].…”

Section: Discussionmentioning

confidence: 99%

“…Such problems led investigators in search of allografts, which have comparable results to the autografting procedures. As a result, some investigators used mixtures of synthetic scaffolding biomaterials and osteoinductive organic agents to achieve better results [1,12,14,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Because resorption of HA takes a relatively long time, HA/TCP mixtures were recently introduced. These mixtures are believed to provide rapid fracture healing and resorption [1,12,14,19,20].…”

Section: Discussionmentioning

confidence: 99%

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Demineralized bone matrix and hydroxyapatite/tri-calcium phosphate mixture for bone healing in rats

Öztürk

Yetkin

Memış

et al. 2006

International Orthopaedics (SICO

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Purpose: Hydroxyapatite/tri-calcium phosphate (HA/TCP) mixture is an osteoconductive material used as a bone graft substitute, and demineralised bone matrix (DBM) is an osteoinductive material. A combination of DBM and HA/TCP mixture would probably create a composite with both osteoconductive and osteoinductive properties. The purpose of this study was to determine the effect of the combination of DBM and HA/TCP mixture on healing of rat radius segmental defects. Methods: Twentyfour adult male Wistar rats were used. Bilateral radial defects were created in each animal. Radial defects were implanted with DBM, HA/TCP mixture and a combination of both substances. Control defects were left unfilled. Ten weeks after implantation, the animals were sacrificed, and the radii were evaluated by radiograhic and histopathological studies. Results: The use of DBM alone demonstrated improved healing on radiographic and histological studies compared to other groups and the control group. There were no differences between the other two groups and the control group. Conclusion: The DBM group showed the best healing response. Combined use of DBM and HA/ TCP mixture did not improve bone healing, and the osteoinductive properties of DBM were inhibited by HA/ TCP mixture. Chaque animal était préparé avec un defect radial bilatéral. Les radius droits des rats ont été implantés soit avec DBM, soit avec HA/TCP isolée, soit avec une combinaison des deux substances, le radius gauche servant de contrôle. Dix semaines après l'implantation, les animaux ont été sacrifiés et les os ont été évalués sur la plan radiographique et histopathologique. L'utilisation de DBM isolée montre une amélioration de la guérison sur le plan radiographique et histologique. On ne retrouve pas de différence avec les autres groupes. En conclusion, le groupe DBM montre une bonne réponse sur le plan de la consolidation. L'utilisation d'une mixture DBM et HA/TCP n'entraîne pas une amélioration et une guérison, les propriétés d'ostéo induction du DBM étant inhibées par le mélange HA/TCP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Demineralized bone matrix and hydroxyapatite/tri-calcium phosphate mixture for bone healing in rats

Öztürk

Yetkin

Memış

et al. 2006

International Orthopaedics (SICO

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“…The literature is contradictory on this point [5,10,13,14,18], as some authors emphasise the osteoinductive properties of this type of graft [28], while others underline the poor results [7,12] in both experimental and clinical studies. This is in agreement with the findings of our study.…”

Section: Discussionmentioning

confidence: 99%

The incorporation of different sorts of cancellous bone graft and the reaction of the host bone. A histomorphometric study in sheep

Léniz

Ripalda

Forriol

2004

International Orthopaedics

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We performed a morphological and histomorphometric analysis of the use of either autografts, or of frozen or freeze-dried cancellous bone allografts in sheep. A cancellous bone defect was created in the lateral portion of the distal epiphysis of the left femur. Four groups of six animals were monitored for 3 months. In the first group, the cavity was filled with autograft, in the second with frozen allograft and in the third with freezedried allograft. In the last group, the cavity was not filled and served as control. A study of the host bone showed that the mean trabecular width of the peripheral osteoid was greatest in the control group, while the number of osteoblasts and osteoclasts was significantly lower in the freeze-dried allograft group. However, the different bone grafts that were used to fill the cavity showed a greater trabecular width and area in the autografts. Among the frozen allografts, these measurements were also greater than in the freeze-dried allograft group. The "erosion surface" of the freeze-dried allograft group was also found to be three times greater, and there were a larger number of osteoclasts and osteoclastic nuclei. We concluded that the "lyophilised" allografts were re-absorbed rapidly and that there were no major morphological differences between the frozen allografts and the autograft groups.Résumé Nous avons fait une analyse morphologique et histomorphométrique d'autogreffe et d'allogreffes spongieuses congelées ou lyophilisées chez le mouton. Un défaut d'os spongieux a été créé dans la portion latérale de l'épiphyse fémorale distale gauche. Quatre groupes de six animaux ont été suivi trois mois. Dans le premier groupe la cavité a été remplie d'autogreffe, dans le second elle a été remplie avec de l'allogreffe congelée et dans le troisième avec de l'allogreffe lyophilisée. Dans le dernier groupe la cavité n'a pas été remplie et a servi comme contrôle. Une étude de l'os de l'hôte a montré que la largeur moyenne du trabecule de l'ostéoïde péri-phérique était plus grande dans le groupe témoin tandis que le nombre d'ostéoblastes et d'ostéoclastes était notablement inférieur dans le groupe d'allogreffe lyophilisée. Cependant les greffes différentes qui ont été utilisées pour remplir la cavité ont montré une plus grande largeur de trabécules avec une plus grande surface dans les autogreffes. Pour l'allogreffe congelée ces dimensions étaient plus grandes que pour l'allogreffe lyophilisée. La surface de résorption de l'allogreffe lyophilisée à aussi été trouvé pour être trois fois plus grande et il y avait un plus grand nombre d'ostéoclastes et de noyaux ostéoclasti-ques. Nous avons conclu que les allogreffes lyophilisées avaient été résorbés rapidement et qu'il n'y avait pas de différence morphologique majeure entre les allogreffes congelées et les autogreffes.

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“…It has already been shown that autologous bone grafts could provide healing of such a defect in a similar model. [25][26][27] We decided not to study a group with BMC alone because this cannot be used in clinical cases for such large defects of a long bone. The cell suspension needs a rigid scaffold or a gel to be maintained in the defect to avoid dispersion of the cells and formation of ectopic bone.…”

Section: Discussionmentioning

confidence: 99%

Coral grafting supplemented with bone marrow

Louisia

Stromboni

Meunier

et al. 1999

The Journal of Bone and Joint Surgery. British volume

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Limited success in regenerating large bone defects has been achieved by bridging them with osteoconductive materials. These substitutes lack the osteogenic and osteoinductive properties of bone autograft. A direct approach would be to stimulate osteogenesis in these biomaterials by the addition of fresh bone-marrow cells (BMC).We therefore created osteoperiosteal gaps 2 cm wide in the ulna of adult rabbits and either bridged them with coral alone (CC), coral supplemented with BMC, or left them empty. Coral was chosen as a scaffold because of its good biocompatibility and resorbability. In osteoperiosteal gaps bridged with coral only, the coral was invaded chiefly by fibrous tissue. It was insufficient to produce union after two months. In defects filled with coral and BMC an increase in osteogenesis was observed and the bone surface area was significantly higher compared with defects filled with coral alone. Bony union occurred in six out of six defects filled with coral and BMC after two months. An increase in the resorption of coral was also observed, suggesting that resorbing cells or their progenitors were present in bone marrow and survived the grafting procedure. Our findings have shown that supplementation of coral with BMC increased both the resorption of material and osteogenesis in defects of a clinical significance.

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A study of the mechanical strength of long bone defects treated with various bone autograft substitutes: An experimental investigation in the rabbit

Cited by 76 publications

References 25 publications

Demineralized bone matrix and hydroxyapatite/tri-calcium phosphate mixture for bone healing in rats

Demineralized bone matrix and hydroxyapatite/tri-calcium phosphate mixture for bone healing in rats

The incorporation of different sorts of cancellous bone graft and the reaction of the host bone. A histomorphometric study in sheep

Coral grafting supplemented with bone marrow

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