2015
DOI: 10.1186/s40659-015-0050-7
|View full text |Cite
|
Sign up to set email alerts
|

A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression

Abstract: BackgroundRecently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease.Meth… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
44
1

Year Published

2016
2016
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 41 publications
(62 citation statements)
references
References 55 publications
5
44
1
Order By: Relevance
“…The severity of periodontal diseases and dental plaques grows, along with a heightened expression of hBD-2 and histatin-5. Higher activity of pro-inflammatory cytokines modulates the progression of the infection, which further stimulates the production of the defensin peptides through various transcription factors [133]. Recently, 89 patients were monitored according to their periodontal status in relation to other clinical parameters [134].…”
Section: Periodontal Diseasesmentioning
confidence: 99%
“…The severity of periodontal diseases and dental plaques grows, along with a heightened expression of hBD-2 and histatin-5. Higher activity of pro-inflammatory cytokines modulates the progression of the infection, which further stimulates the production of the defensin peptides through various transcription factors [133]. Recently, 89 patients were monitored according to their periodontal status in relation to other clinical parameters [134].…”
Section: Periodontal Diseasesmentioning
confidence: 99%
“…Six studies were with regard to salivary concentration of antimicrobial peptides (AMPs). This group includes peptides which present an ability to kill or inhibit bacterial growth (e.g., defensins, cathelicidins and histatins) (Colombo, Ribas, et al, ; Davidopoulou, Diza, Menexes, & Kalfas, ; Jurczak et al, ; Malcolm et al, ; Tao et al, ; Toomarian, Sattari, Hashemi, Tadayon, & Baghban, ; Yang, Li et al, ; Yang, Zhou et al, ). As in the case of immunoglobulins, the obtained results varied.…”
Section: Discussionmentioning
confidence: 99%
“…As in the case of immunoglobulins, the obtained results varied. Some authors claim significant increase in salivary β‐defensin 2 (Jurczak et al, ), histatin 5 (Jurczak et al, ), cathelicidin LL37 (Davidopoulou et al, ; Malcolm et al, ) or α‐defensin (Malcolm et al, ) in patients with high caries intensity or high quantity of S. mutans. Colombo, Ribas, et al () and Toomarian et al () did not notice such dependencies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…One cannot talk about the microflora of teeth focusing only on the selected anatomical areas associated with certain bacterial species. Also the number of pathogenic species occupying specific ecological niches is not synonymous with the development of caries [15][16][17][18].…”
Section: Formation Of Oral Cavity Microbiomementioning
confidence: 99%