A systematic review and meta-analysis of lipid metabolomic signatures of Major Depressive Disorder

Bharti, Veni; Bhardwaj, Aseem; Hood, Kalli; Elias, Damian O.; Metcalfe, Arron W.S.; Kim, Jong Sung

doi:10.1016/j.jpsychires.2021.05.036

Cited by 29 publications

(9 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study published in 2018 suggested that PTSD patients represent high dehydroepiandrosterone (DHEA) levels in contrast to MDD patients who exhibit low DHEA levels (91). Previous studies have shown that long-term oral DHEA therapy reduced HDL levels (92,93), which is consistent with our results showing reduced HDL in PTSD patients and not in MDD patients (90). HDL plays a key role in reverse cholesterol transport and promotes the efflux of cholesterol from peripheral tissues, hepatocytes, and macrophages, leading to an overall reduction in the levels of TC (94).…”

Section: Discussionsupporting

confidence: 92%

“…In summary, PTSD is positively associated with the levels of TC, LDL, and TG and negatively associated with the levels of HDL, indicating that this pattern may serve as a biomarker to assess the risk of PTSD in potential patients that otherwise have no obvious health-related indicators for exhibiting this lipid profile. In our previous meta-analysis study (90), pattern of the lipid profiles of patients with major depressive disorder (MDD) were found to be different than our current analysis in PTSD patients. MDD patients showed a reduction in TC levels, increase in the levels of TG and VLDL, and no changes in LDL and HDL levels (90).…”

Section: Discussioncontrasting

confidence: 91%

“…In our previous meta-analysis study (90), pattern of the lipid profiles of patients with major depressive disorder (MDD) were found to be different than our current analysis in PTSD patients. MDD patients showed a reduction in TC levels, increase in the levels of TG and VLDL, and no changes in LDL and HDL levels (90). However, our results indicate that PTSD patients show an increase in total cholesterol, LDL, and TG, and a reduction in HDL levels.…”

Section: Discussioncontrasting

confidence: 91%

“…HDL plays a key role in reverse cholesterol transport and promotes the efflux of cholesterol from peripheral tissues, hepatocytes, and macrophages, leading to an overall reduction in the levels of TC (94). Since MDD patients represented no changes in HDL levels compared to healthy controls (90), this may explain decrease in TC in contrast to PTSD patients who show increased TC. Second, this work will be useful for physicians when considering the risk while assessing lipid levels in PTSD patients to reduce the cardiovascular morbidity and mortality in these patients.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

et al. 2022

Self Cite

View full text Add to dashboard Cite

BackgroundResearch assessing lipid levels in individuals diagnosed with post-traumatic stress disorder (PTSD) has yielded mixed results. This study aimed to employ meta-analytic techniques to characterize the relationship between the levels of lipid profiles and PTSD.MethodsWe performed meta-analyses of studies comparing profiles and levels of lipids between PTSD patients and healthy individuals by searching Embase, Ovid Medline, Scopus, PsycINFO, and Cochrane databases for the studies until March 2021. Meta-analyses were performed using random-effects models with the restricted maximum-likelihood estimator to synthesize the effect size assessed by standardized mean difference (SMD) across studies.FindingsA total of 8,657 abstracts were identified, and 17 studies were included. Levels of total cholesterol (TC) (SMD = 0.57 95% CI, 0.27–0.87, p = 0.003), low-density lipoprotein (LDL) (SMD = 0.48, 95% CI, 0.19–0.76, p = 0.004), and triglyceride (TG) (SMD = 0.46, 95% CI, 0.22–0.70, p = 0.001) were found to be higher, while levels of high-density lipoprotein (HDL) (SMD = –0.47, –0.88 to –0.07, p = 0.026) were found to be lower in PTSD patients compared to healthy controls. Subgroup analysis showed that TG levels were higher in PTSD patients who were on or off of psychotropic medications, both < 40 and ≥ 40 years of age, and having body mass index of < 30 and ≥ 30 compared to healthy controls.InterpretationThis work suggested dysregulation of lipids in PTSD that may serve as biomarker to predict the risk. The study will be useful for physicians considering lipid profiles in PTSD patients to reduce cardiovascular morbidity and mortality.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 91%

Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In recent years, an increasing number of studies have suggested that lipid abnormalities may play an important role in the pathophysiology of MDD [ 4 – 6 ], but findings regarding this association are inconsistent. Some studies found lower total cholesterol (TC) in subjects with MDD versus control [ 7 , 8 ], while others reported higher TC [ 9 ] or found no differences [ 10 ]. These contradictory findings might result from the relatively small sample size, samples with a restricted age range, or single-sex groups in some studies.…”

Section: Introductionmentioning

confidence: 99%

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

Zheng

Zhao

et al. 2022

Transl Psychiatry

View full text Add to dashboard Cite

Major depressive disorder (MDD) involves changes in lipid metabolism, but previous findings are contradictory. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is considered to be a regulator of lipid metabolism. To date, the function of MANF has been studied in many brain disorders, but not in MDD. Therefore, to better understand the role of lipids in MDD, this study was conducted to examine lipid levels in the serum of MDD patients and to investigate the potential function of MANF in MDD. First, the data on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) in serum from 354 MDD patients and 360 healthy controls (HCs) were collected and analyzed. The results showed that there were significantly lower concentrations of TC and LDL-C in MDD patients compared with HCs, and TC levels were positively correlated with LDL-C levels. Bioinformatics analysis indicated that MANF/EWSR1/ANXA6 pathway might serve as the connecting bridge through which hypolipidemia played a functional role in MDD. Second, to verify this hypothesis, serum samples were collected from 143 MDD patients, and 67 HCs to measure the levels of MANF, EWSR1, and ANXA6 using ELISA kits. The results showed that compared to HCs, MDD patients had a significantly lower level of MANF and higher levels of ANXA6 and EWSR1, and these molecules were significantly correlated with both TC level and Hamilton Depression Rating Scales (HDRS) score. In addition, a discriminative model consisting of MANF, EWSR1, and ANXA6 was identified. This model was capable of distinguishing MDD subjects from HCs, yielded an area under curve of 0.9994 in the training set and 0.9569 in the testing set. Taken together, our results suggested that MANF/EWSR1/ANXA6 pathway might act as the bridge between hypolipidemia and MDD, and these molecules held promise as potential biomarkers for MDD.

show abstract

Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study

Peng

Wang

Zhou

et al. 2023

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

A systematic review and meta-analysis of lipid metabolomic signatures of Major Depressive Disorder

Cited by 29 publications

References 83 publications

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

A Systematic Review and Meta-Analysis of Lipid Signatures in Post-traumatic Stress Disorder

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study

Contact Info

Product

Resources

About