A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

Abstract

Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA. Graphic Abstract

Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial

“…Pumpkin ( Cucurbita pepo) belongs to the squash family and is rich in phytosterols that actively inhibits the conversion of testosterone to dihydrotestosterone (DHT) 14,15 . One study compared the use of oral daily 400mgs of PSO to oral placebo in 76 patients with AGA and demonstrated a 40% increase in hair count among pumpkin seed oil users 7 …”

“…Pumpkin seed oil is a rich source of unsaturated fatty acids, especially oleic acid and linoleic acid. Such essential acids are reported to inhibit 5α‐reductase, and hence, they might contribute to its hair growth potential via their anti‐androgen effects 14 …”

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

“…Hair restoration is one of the most technologically developed facets of anti-aging [1]. It combines knowledge of hormonal modulation for hair follicle stimulation [2,3], with genetic factors and novel therapeutics including small molecules, peptides transferosomes and exosomes [4][5][6]. Topical formulations, natural products and oral supplements abound as interventions with mixed data on their usage [4].…”

“…It combines knowledge of hormonal modulation for hair follicle stimulation [2,3], with genetic factors and novel therapeutics including small molecules, peptides transferosomes and exosomes [4][5][6]. Topical formulations, natural products and oral supplements abound as interventions with mixed data on their usage [4]. The link between androgens and hair loss is known and recently has come into more focus in the era of COVID-19 and hair loss due to the fact that Coronavirus appears to elicit androgenic responses [4,5].…”

“…Topical formulations, natural products and oral supplements abound as interventions with mixed data on their usage [4]. The link between androgens and hair loss is known and recently has come into more focus in the era of COVID-19 and hair loss due to the fact that Coronavirus appears to elicit androgenic responses [4,5]. Hair loss can be triggered by drugs and radiation as well as hormonal imbalance [7,8].…”