Abstract-We propose a color barcode framework for mobile phone applications by exploiting the spectral diversity afforded by the cyan (C), magenta (M), and yellow (Y) print colorant channels commonly used for color printing and the complementary red (R), green (G), and blue (B) channels, respectively, used for capturing color images. Specifically, we exploit this spectral diversity to realize a three-fold increase in the data rate by encoding independent data in the C, M, and Y print colorant channels and decoding the data from the complementary R, G, and B channels captured via a mobile phone camera. To mitigate the effect of cross-channel interference among the printcolorant and capture color channels, we develop an algorithm for interference cancellation based on a physically-motivated mathematical model for the print and capture processes. To estimate the model parameters required for cross-channel interference cancellation, we propose two alternative methodologies: a pilot block approach that uses suitable selections of colors for the synchronization blocks and an expectation maximization approach that estimates the parameters from regions encoding the data itself. We evaluate the performance of the proposed framework using specific implementations of the framework for two of the most commonly used barcodes in mobile applications, QR and Aztec codes. Experimental results show that the proposed framework successfully overcomes the impact of the color interference, providing a low bit error rate and a high decoding rate for each of the colorant channels when used with a corresponding error correction scheme.