A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Liu, Zhiming; Chen, Haolin; Jia, Yali; Zhang, Wen; Zhao, Henan; Fan, Wendong; Zhang, Wolun; Zhong, Huiqing; Ni, Yirong; Guo, Zhouyi

doi:10.1039/c8nr05300f

Cited by 90 publications

(60 citation statements)

References 48 publications

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“…(C-N stretching in protein, chain C-C stretching in lipid), 1145 cm −1 (ribose-phosphate), 1170 cm −1 (C-C/ C-N stretching in protein), 1376 cm −1 (thymine, adenine, guanine), 1586 cm −1 (amide II, phenylalanine, tyrosine, adenine, guanine), and 1620 cm −1 (C=C olefinic stretching in protein, nucleotide, lipid) [43][44][45][46], which may be ascribed to the thermal denaturation induced by the NIR laser. Among them, we can notice that most of these peaks assigned to proteins and nucleotides are attenuated significantly; the vibrational mode of collagen (proline, 918 cm −1 ) also declines obviously, suggesting both the intracellular and extracellular microstructures of tumor tissues are severely destroyed after laser irradiation.…”

Section: Resultsmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

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Research on deep-tissue photothermal therapy (PTT) in the near-infrared II (NIR-II, 1000-1350 nm) region has bloomed in recent years, owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I (NIR-I, 650-950 nm) region. However, more details need to be uncovered to facilitate a fundamental understanding of NIR-II PTT. Herein, a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide (MoO 2) nanoaggregates was fabricated. The photothermal conversion capabilities of MoO 2 in the NIR-I and II regions were investigated step by step, from a simple tissue phantom to a three-dimensional cellular system, and further to a tumor-bearing animal model. NIR-II laser exhibited a lower photothermal attenuation coefficient (0.541 at 1064 nm) in a tissue phantom compared with its counterpart (0.959 at 808 nm), which allows it to be more capable of deeptissue PTT in vitro and in vivo. Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth. Moreover, the depth-related tumor ablation was also studied by Raman fingerprint analysis, which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues, providing fundamental knowledge to NIR-II deeptissue photothermal therapy.

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Section: Resultsmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

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“…Thus, nano‐BP that enables reliable in vivo thermal imaging can be regarded as an ideal thermal agent. BPQDs and BP nanoparticles have already been applied to achieve in vivo thermal imaging for tumor‐bearing mice after 808 nm laser irradiation . The nanocomposites of BP nanosheets/cellulose (namely cellulose/BPNSs) showed the reliable results in in vivo NIR thermal imaging of tumor‐bearing mice .…”

Section: Biomedical Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

200

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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“…Among these, the optical anisotropy enables the 2D BP to be promising for functional optoelectronics as the optical anisotropy provides another free degree to create the nanosized optoelectronic and photonic devices. [ 12 ] However, the optical anisotropic strength of 2D BP is low because the ultrathin thickness of few‐layer BP weakens the light–matter interaction [11c,13] . Enhancement of the light–2D BP interaction can significantly facilitate the 2D BP toward the practical applications of photonic devices.…”

Section: Introductionmentioning

confidence: 99%

Gap‐Plasmon Induced One‐Order Enhancement of Optical Anisotropy of 2D Black Phosphorus

Jia

Chen

Ban

et al. 2020

Advanced Photonics Research

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Anisotropic 2D materials with unique thermoelectric, electrical, and optical characteristics offer prospects for various angle-dependent devices. Yet, few anisotropic 2D materials are exploited. Black phosphorus (BP) is a newly rediscovered 2D material with striking in-plane anisotropy. However, experimental illustrations of the optical anisotropy of 2D BP are very limited presumably due to the ultrathin thickness of the few-layered BP which weakens the lightmatter interaction. To solve this problem, herein a hybrid nanostructure is fabricated using a one-step self-assembly deposition of gold (Au) nanoparticle (NP) clusters onto the few-layered BP residing on a silica (SiO 2) substrate. Such a hybrid nanostructure can squeeze the light into AuNPs-SiO 2 gap through the gap plasmon resonance, enabling the confined light to interact efficiently with the ultrathin BP film. Angle-resolved polarized Raman spectra measurement is carried out to study the influence of the AuNPs on the in-plane optical anisotropy of the BP. About 20 times enhancement of Raman intensity anisotropy is experimentally achieved using AuNPs. The AuNPs-BP system is not only useful for high-performance polarization-dependent photonic devices but also a universal methodology for exploring the in-plane anisotropy of low-symmetry 2D materials. Furthermore, the high-throughput self-assembly fabrication shows its potential for industrial-scale manufacturability.

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A two-dimensional fingerprint nanoprobe based on black phosphorus for bio-SERS analysis and chemo-photothermal therapy

Cited by 90 publications

References 48 publications

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Gap‐Plasmon Induced One‐Order Enhancement of Optical Anisotropy of 2D Black Phosphorus

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