A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder

Waiter, Gordon D.; Williams, Justin H. G.; Murray, Alison; Gilchrist, Anne; Perrett, David I.; Whiten, Andrew

doi:10.1016/j.neuroimage.2004.02.029

Cited by 211 publications

(160 citation statements)

References 44 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…This finding of morphometric alterations of the OFC is consistent with several (McAlonan et al, 2005;Salmond et al, 2003), but not all (Abell et al, 1999;Boddaert et al, 2004;Carper and Courchesne, 2005;Kwon et al, 2004;Waiter et al, 2004), imaging studies. Differences in the morphometric methodologies applied and sample sizes used could explain the inconsistencies in these findings, such as the absence of bilateral alterations in the present study in contrast to the observations of two recent voxel-based morphometry studies reporting structural abnormalities in several brain regions including right and left OFC (McAlonan et al, 2005;Salmond et al, 2003).…”

Section: Discussionsupporting

confidence: 88%

Volumetric alterations of the orbitofrontal cortex in autism

Girgis

Minshew

Melhem

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Recent evidence has implicated the orbitofrontal cortex (OFC) in the pathophysiology of social deficits in autism. An MRI-based morphometric study of the OFC was conducted involving 11 children with autism (age range 8.1-12.7 years) and 18 healthy, age-matched controls (age range 8.9-12.8 years). Decreased grey matter volume in the right lateral OFC in the patient group was found, and correlations were observed between social deficits and white, but not grey, matter structures of the OFC. These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies.

show abstract

Section: Discussionsupporting

confidence: 88%

Volumetric alterations of the orbitofrontal cortex in autism

Girgis

Minshew

Melhem

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…11,12 These areas also have been found affected in our study. Higher than normal density, not observed by us, has been reported in inferior frontal cortex 10,13 and cerebellum. 3,8,14 Other investigations identified areas of higher or lower GM density that were unaffected in our patients, such as the amygdala, 8 cingulate gyrus, 8,11 fusiform gyrus, 10,14 and thalamus.…”

Section: Discussioncontrasting

confidence: 58%

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Riva¹,

Bulgheroni²,

Aquino³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…For example, an MRI study revealed anatomical displacement of major sulci in frontal and temporal brain regions in children with ASD (mean age 10.7 ± 3.1 std) relative to healthy children (mean age 11.3 ± 2.9 std), including anterior and superior displacements of the superior temporal sulcus bilaterally [61]. A voxel-based morphometry analysis of the brains of children with ASD (mean age 15.4 ± 2.2 std) compared to IQ matched controls (mean age 15.5 ± 1.6 std) found total brain gray matter volume increases and localized increases that included the right superior temporal gyrus [62]. Also using voxel-based morphometry, Boddaert et al (2004) found contrary results in children with ASD (mean age 9.3 ± 2.2 std), with decreases of grey matter volume localized to the STS compared to healthy controls (mean age 10.8 ± 2.7 std) [63].…”

Section: The Neural Basis Of Anomalous Gaze Processing In Asdmentioning

confidence: 98%

Autism and the development of face processing

Golarai

Grill-Spector

Reiss

2006

Clinical Neuroscience Research

158

View full text Add to dashboard Cite

Autism is a pervasive developmental condition, characterized by impairments in non-verbal communication, social relationships and stereotypical patterns of behavior. A large body of evidence suggests that several aspects of face processing are impaired in autism, including anomalies in gaze processing, memory for facial identity and recognition of facial expressions of emotion. In search of neural markers of anomalous face processing in autism, much interest has focused on a network of brain regions that are implicated in social cognition and face processing. In this review, we will focus on three such regions, namely the STS for its role in processing gaze and facial movements, the FFA in face detection and identification and the amygdala in processing facial expressions of emotion. Much evidence suggests that a better understanding of the normal development of these specialized regions is essential for discovering the neural bases of face processing anomalies in autism. Thus, we will also examine the available literature on the normal development of face processing. Key unknowns in this research area are the neuro-developmental processes, the role of experience and the interactions among components of the face processing system in shaping each of the specialized regions for processing faces during normal development and in autism. Published by Elsevier B.V. on behalf of Association for Research in Nervous and Mental Disease.

show abstract

A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder

Cited by 211 publications

References 44 publications

Volumetric alterations of the orbitofrontal cortex in autism

Volumetric alterations of the orbitofrontal cortex in autism

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Autism and the development of face processing

Contact Info

Product

Resources

About