Action and interaction of fluoride in dentifrices

Forward, G.C.

doi:10.1111/j.1600-0528.1980.tb01297.x

Cited by 23 publications

(17 citation statements)

References 49 publications

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“…A lack of effect of toothpastes contain ing monofluorophosphate on the acidogenicity of plaque has in fact been report ed [Forward, 1980], whereas a reduced acidogenicity was observed when an aqueous solution of monofluorophosphate was ap plied [Afseth, 1981]. Another possible mechanism by which lauryl sulphate may reduce the caries inhibiting effect of monofluorophosphate could be that the strongly anionic detergent molecule may compete with fluoride ions for receptor sites in plaque or dental enamel [Rolla and Bowen, 1977].…”

Section: Discussionmentioning

confidence: 99%

Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Melsen

Rölla

1983

Caries Res

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It was shown that addition of 2% sodium lauryl sulphate to a 3% aqueous solution of sodium monofluorophosphate reduced the caries-inhibiting potential of the monofluorophosphate solution significantly, when this solution was applied topically at fortnightly intervals. It is suggested that this may be due to enzyme inhibition by the lauryl sulphate, denaturing bacterial enzymes in the oral cavity which would otherwise release free fluoride from the monofluorophosphate molecule. Almost all commercial toothpaste with sodium monofluorophosphate contains high amounts of sodium lauryl sulphate. It is suggested that this may impair the clinical effect of these toothpastes.

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Section: Discussionmentioning

confidence: 99%

Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Melsen

Rölla

1983

Caries Res

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“…An interesting observation of fluoride up take by hydroxyapatite powder from MFP and F" mixtures was made by Forward [1980] where he found that a 100 ppm F solu tion containing equal moles of PO,F2~ and F" deposited significantly more fluoride into the enamel than the same amount of fluoride from either agent alone. This shows that P 0 3F2_ and F ' react in different ways with enamel.…”

Section: Enamel Layermentioning

confidence: 99%

Monofluorophosphate Utilization in Oral Preparations: Laboratory Observations

Mellberg¹

1983

Caries Res

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The major use of sodium monofluorophosphate (MFP) in oral preparations is in dentifrices. Some MFP has been used or evaluated in prophylactic pastes, occlusal sealants, dental cements and mouthrinses. In laboratory experiments, MFP has been found to reduce enamel solubility and deposit fluoride in enamel. Although fluoride uptake by enamel from MFP is less than from NaF in vitro in relatively short-term animal experiments, other evidence suggests it is the same as NaF over a longer treatment period in vivo. MFP solutions and dentifrices have been shown to accelerate remineralization of artificial caries lesions both in vitro and in vivo. Significant mineral acquisition by the body of the lesion has been demonstrated within 2 weeks in vitro. After 2 months in vivo, mineral was deposited at the advancing front of the lesion reducing the depth by 19%.

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“…This effi cacy was also shown by the silica-based dentifrice but only in the presence of test plaque. Calcium carbonate (CaCO 3 ) is an alkaline, buffering agent used in dentifrice as an abrasive [Forward, 1980]. It is compatible with sodium monofl uorophosphate (MFP) and 92% of the dentifrices found on the Brazilian…”

mentioning

confidence: 99%

Effect of a Calcium Carbonate-Based Dentifrice on in situ Enamel Remineralization

et al. 2005

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This crossover study evaluated the effect of calcium carbonate (CaCO₃)-based monofluorophosphate dentifrice on enamel remineralization. Ten volunteers wore palatal appliances containing four enamel blocks with caries-like lesions, two of them covered by a test plaque of mutans streptococci. The following treatments were evaluated: a negative control, a silica-based or a CaCO₃-based dentifrice, and the percentage of enamel surface microhardness recovery was determined. The CaCO₃-based dentifrice was more effective than the negative control on the enhancement of enamel remineralization, either in the presence or absence of test plaque. This efficacy was also shown by the silica-based dentifrice but only in the presence of test plaque.

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Action and interaction of fluoride in dentifrices

Cited by 23 publications

References 49 publications

Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Monofluorophosphate Utilization in Oral Preparations: Laboratory Observations

Effect of a Calcium Carbonate-Based Dentifrice on in situ Enamel Remineralization

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