Acute generalized exanthematous pustulosis after ceftriaxone use resembling sepsis

Kaya, Abdurrahman; Yıldız, Sibel; Balkan, İ̇lker İnanç; Eyvazov, Hayyam; Bavunoğlu, İşıl; Mert, Ali

doi:10.1007/s10156-011-0297-z

Cited by 11 publications

(14 citation statements)

References 10 publications

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“…AGEP due to ceftriaxone has been previously reported during childhood, with confirmation of the offending drug with patch testing performed in one patient . Adult patients with ceftriaxone‐induced AGEP have also been reported in the literature; however, confirmation with patch testing was not performed in these reports either . Drug patch testing in patients with delayed‐type CADR is considered safe, although relapse of AGEP during patch testing has been reported .…”

Section: Discussionmentioning

confidence: 95%

Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

Salman

Yücelten

Çakıcı

et al. 2019

Pediatric Dermatology

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Acute generalized exanthematous pustulosis (AGEP) is seen uncommonly in children and sometimes shows atypical clinical features in this population. Patch testing can be used effectively in children for the confirmation of the culprit drug in cases of multiple drug use. Here, we report a rare, pediatric case of ceftriaxone‐induced AGEP confirmed by patch testing with subsequent recurrence of the skin eruption.

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Section: Discussionmentioning

confidence: 95%

Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

Salman

Yücelten

Çakıcı

et al. 2019

Pediatric Dermatology

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“…We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions. We also highlight specific cases in which the clinical course of AGEP varied to demonstrate the potential for mortality in certain settings …”

Section: Introductionmentioning

confidence: 99%

“…). Medications implicated in this phenomenon have included hydroxychloroquine, valdecoxib, paracetamol, infliximab and clindamycin, beta‐lactam antibiotics, famotidine, carbamazepine, lamotrigine and estazolam …”

Section: Introductionmentioning

confidence: 99%

“…In virtually all TEN‐like AGEP cases, the clinical course most closely resembles AGEP with full recovery. However, four cases have been described in which AGEP mimicking TEN resulted in significant hypotension and shock with end‐organ dysfunction, although these patients recovered with aggressive supportive care and other treatments . We have recently reported a case of AGEP mimicking TEN that resulted in death .…”

Section: Introductionmentioning

confidence: 99%

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Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.

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“…In the patch test area, pustular lesions on the erythematous surface was seen as reported elsewhere (Figure 2). The AGEP was reported in 2 patients aged 31 and 70 using ceftriaxone for acute pyelonephritis [11, 12]. No sensitivity level was shown with a patch test in these cases.…”

Section: Discussionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis induced by ceftriaxone use

Nacaroğlu¹,

Çeleğen²,

Özek³

et al. 2014

pdia

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Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive crisis and on the third day of ceftriaxone treatment, erythematous pustular lesions accompanied with fever were observed on the body and extremities. Resolution of symptoms followed discontinuation of ceftriaxone. Sensitivity to ceftriaxone was shown with a patch test. The AGEP was considered due to clinical and histopathological findings. This is the first pediatric case of AGEP due to ceftriaxone.

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Acute generalized exanthematous pustulosis after ceftriaxone use resembling sepsis

Cited by 11 publications

References 10 publications

Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Acute generalized exanthematous pustulosis induced by ceftriaxone use

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