Acute Toxicity and Gastroprotective Effect of the Schiff Base Ligand 1H-Indole-3-ethylene-5-nitrosalicylaldimine and Its Nickel (II) Complex on Ethanol Induced Gastric Lesions in Rats

Abstract

The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its nickel complex. Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with edema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either cimetidine or TNS and its nickel (II) compound, where there was marked gastric protection along with reduction of edema and leucocytes infiltration of the submucosal layer. Acute toxicity study done on mice with a higher dose of 5 g/kg of TNS and its nickel (II) complex did not manifest any toxicological signs. Research finding suggest that TNS and its nickel (II) complex could be considered as effective gastroprotective compounds.

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

“…The generation of ROS by ethanol led to downregulation of HSP70 expression and upregulation of Bax proteins. Otherwise, Bax protein expression was downregulated and HSP70 protein expression was upregulated in the group pretreated with C. barometz leaf extract compared to the ulcerated group, which agrees with the results of many researchers reported 10,12,35,36,68…”

The Gastroprotective Effect of Vitex pubescens Leaf Extract against Ethanol-Provoked Gastric Mucosal Damage in Sprague-Dawley Rats

“…The ulcerated area was determined by counting the number of small squares, 2 mm × 2 mm, covering the length and width of each ulcer band. The total areas of all lesions were included in the calculation of the ulcer area (UA) based on the number of small squares × 4 × 1.8 = UA (mm 2 ), according to the recommendation of [ 31 ]. The inhibition percentage (I.0%) was calculated by the following formula based on the recommendation of [ 16 ].…”

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

“…[14][15][16] Schiff base metal complexes are gaining considerable attention due to their potential antifungal, antitumor and antibacterial activities. [17][18][19][20] Use of labile and auxiliary ligands like 1,10-phenenthroline, 2,2-bipyridyl, imidazole, and pyridine, on the other hand, have been demonstrated to show interesting biological prole with excellent antibacterial, antitumor, antiviral and antifungal activities already reported. [21][22][23][24][25] A good number of mixed ligand complexes containing 1,10-phenanthroline as a ligand are identied as potential chemotherapeutic agents and have received much attention in the eld of medicine.…”