Acute toxicity studies and protective effects of
 Cinnamon cassia
 bark extract in streptozotocin-induced diabetic rats

Vijayakumar, K; Rengarajan, Rengasamy Lakshminarayanan; Suganthi, N; Prasanna, B; Velayuthaprabhu, Shanmugam; Madhavan, Shenbagam; Anand, Arumugam Vijaya

doi:10.1080/01480545.2021.1907908

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…GST plays a vital role in protecting tissue from the harmful effects of toxic substances and influences the lipid peroxide involved reactions. GST involves the conjugation activity towards 4-hydroxynoneal and produces the LPO (Jensen et al, 1986;Khan et al, 2016;Vijayakumar et al, 2021). The present study's findings noted that a decreasing level of GST is inversely proportional to the increasing concentration of LPO.…”

Section: Enzyma C An Oxidantssupporting

confidence: 52%

Antioxidant and antidiabetic activity of Andrographis paniculata and Rhinacanthus nasutus in isoniazid and rifampicin induced Wistar rats

G¹,

Manikandan²,

Velayuthaprabhu³

et al. 2022

NRFHH

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The present investigation aimed to identify the effects of ethanolic extract of Andrographis paniculata Linn. and Rhinacanthus nasutus Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of A. paniculata and R. nasutus have an antioxidant effect and anti-diabetic activity against the toxin treated rats.

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Section: Enzyma C An Oxidantssupporting

confidence: 52%

Antioxidant and antidiabetic activity of Andrographis paniculata and Rhinacanthus nasutus in isoniazid and rifampicin induced Wistar rats

G¹,

Manikandan²,

Velayuthaprabhu³

et al. 2022

NRFHH

Self Cite

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“…Cinnamon has a good antitumor and immunostimulatory potencies may be attributed as a bright anticancer nominee (1) . The findings provided scientific support for the plant's usage in traditional medicine to treat diabetes and its consequences by showing improved mitochondrial enzymes, hepatic marker enzymes, renal marker enzymes (2) . Cinnamaldehyde, eugenol, volatile oils and oleoresin, derivatives like cinnamaldehyde, cinnamic acid and cinnamate are majorly present in cinnamon (3)(4)(5) .…”

Section: Introductionmentioning

confidence: 82%

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Kalaivani,

Murali,

Sathya

et al. 2023

IJST

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Objective:The current review identifies the adverse and beneficial effects of cinnamon and its components. Method: Literature search using online databases including PubMed, Hindawi, ScienceDirect, ResearchGate, and Elsevier were explored. The keywords used for the literature search included cinnamon, cinnamaldehyde, trans-cinnamaldehyde, cinnamon and stroke, cinnamon and antioxidant, and cinnamon and toxic effects. The inclusion criteria for this review encompassed studies that focused on neuroinflammation and neuroprotection, as well as those that examined the effects of stroke. Additionally, the criteria included studies that investigated experiments on ischemic hemorrhage, encompassing both in vivo and in vitro settings. Findings: The comparative analysis of studies reveals that cinnamon demonstrates potent antioxidant, anticholinergic, and antidiabetic effects. Cinnamaldehyde exhibits inhibitory effects on collagen and thrombin-induced platelet aggregation, as well as collagen-epinephrine-induced acute pulmonary thromboembolism, suggesting its antithrombotic properties. Moreover, transcinnamaldehyde reduces the brain infarct area by downregulating the gene expression of iNOS, COX-2, and TNF-alpha, thus reducing inflammation associated with ischemic stroke. Additionally, the literature review highlights the neuroprotective properties of cinnamon in treating Alzheimer's disease and Parkinson's disease. Consequently, further research is required to elucidate the potential mechanisms through which cinnamon provides neuroprotection and its efficacy in stroke treatment. Novelty: The review reiterates for bioactive compounds present in cinnamon which show promising potential in the treatment of neurodegenerative disorders and stroke.

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“…Yun et al [ 175 ] have reported that cinnamon extract (2 g/kg body weight/day for 13 weeks) might result in nephrotoxicity and hepatotoxicity in rats due to high doses of coumarin. In animals, despite all the extracts tested showing possible antioxidant activity in vitro , they showed acute dose-dependent toxicity (1,000, 2,000, 3,000, 4,000, and 5,000 mg/kg body weight) in vivo , with increased levels of aspartate transaminase, alanine transaminase ALP, urea, and creatinine reported in animals treated with the highest dose [ 57 ].…”

Section: Toxicity Caused By Cinnamonmentioning

confidence: 99%

Cinnamon: an aromatic condiment applicable to chronic kidney disease

Moreira

Brum

Reis

et al. 2023

Kidney Res Clin Pract

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Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and hasshown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention forchronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamicacid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are commoncomplications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complicationsobserved in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.

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Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats

Cited by 7 publications

References 43 publications

Antioxidant and antidiabetic activity of <i>Andrographis paniculata</i> and <i>Rhinacanthus nasutus</i> in isoniazid and rifampicin induced Wistar rats

Antioxidant and antidiabetic activity of <i>Andrographis paniculata</i> and <i>Rhinacanthus nasutus</i> in isoniazid and rifampicin induced Wistar rats

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Cinnamon: an aromatic condiment applicable to chronic kidney disease

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