Adaptive Control of Blood Pressure

Arnsparger, John M.; McInnis, B.; Normann, Nils A.

doi:10.1109/tbme.1983.325101

Cited by 90 publications

(14 citation statements)

References 6 publications

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“…The LPV controller has been compared with the adaptive control method of (Ansparger et al, 1983), where an auto-regressive model was used for capturing MAP response of patients subject to vasoactive drug injections. The driving equation of the ARMA model is given as:…”

Section: Closed-loop Simulation Resultsmentioning

confidence: 99%

“…As suggested in (Ansparger et al, 1983) a second-order ARMA process had been constructed, initialized with nominal patient parameters and used with forgetting factor λ = 1 and control weighting κ = 10 −3 . Graphical results for three representative cases are given in the sequel:…”

Section: Closed-loop Simulation Resultsmentioning

confidence: 99%

“…Drugs to lower the blood pressure, such as sodium nitroprusside, or drugs to raise the blood pressure, such as phenylephrine or vasopressin, are administrated to reach desired mean arterial pressure (MAP) targets in surgical procedures or in emergency resuscitation due to hemorrhage or trauma. Closed-loop feedback control algorithms to regulate blood pressure have been proposed to automate the administration of drugs and potentially reduce variability and drug overdose (Ansparger, McInnis, Glover & Normann, 1983;Isaka & Sebald, 1993). Model-based adaptive controllers proposed for the automatic regulation of blood pressure can be categorized into three main groups.…”

Section: Introductionmentioning

confidence: 99%

“…Model-based adaptive controllers proposed for the automatic regulation of blood pressure can be categorized into three main groups. The first group is the self-tuning regulators, which built up from a recursive identification algorithm, where the parameters of a dynamic response model are determined, and a subsequent calculation of the control input (Ansparger et al, 1983;Hahn, Edison & Edgar, 2002). (Kaufman, Roy & Xu, 1984) illustrates the method of model-reference based control algorithms.…”

Section: Introductionmentioning

confidence: 99%

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Robust linear parameter-varying control of blood pressure using vasoactive drugs

Luspay

Grigoriadis

2015

International Journal of Control

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Resuscitation of emergency care patients requires fast restoration of blood pressure to a target value to achieve hemodynamic stability and vital organ perfusion. A robust control design methodology is presented in this paper for regulating blood pressure of hypotensive patients by means of closed-loop administration of vasoactive drugs. To this end, a dynamic first-order delay model is utilized to describe the vasoactive drug response with varying parameters that represent intra-patient and inter-patient variability. The proposed framework consists of two components: firstly, an on-line model parameter estimation is carried out using a multiple-model extended Kalman-filter. Secondly, the estimated model parameters are used for continuously scheduling a robust linear parameter varying (LPV) controller. The closed-loop behavior is characterized by parameter-varying dynamic weights designed to regulate the mean arterial pressure to a target value. Experimental data of blood pressure response of anesthetized pigs to phenylephrine injection are used for validating the LPV blood pressure models. Simulation studies are provided to validate the on-line model estimation and the LPV blood pressure control using phenylephrine drug injection models representing patients showing sensitive, nominal and insensitive response to the drug.

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Section: Closed-loop Simulation Resultsmentioning

confidence: 99%

Section: Closed-loop Simulation Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Robust linear parameter-varying control of blood pressure using vasoactive drugs

Luspay

Grigoriadis

2015

International Journal of Control

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“…In 1981, Stern et al described simulation experiments indicating that a self-tuning regulator should provide excellent control when the mean arterial pressure is lowered by nitroprusside. Arnsparger et al (1983) have recently reported good control of mean arterial pressure in the anaesthetised dog using a self-tuning controller.…”

Section: Control Strategiesmentioning

confidence: 99%

Closed Loop Control

Chizeck¹,

Katona²

1985

Computers and Control in Clinical Medicine

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Blood Pressure, Automatic Control of

2006

Encyclopedia of Medical Devices and Instrumentation

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Automatic blood pressure control is a technique that regulates the infusion rates of pharmacological agents automatically to maintain a patient’s mean arterial pressure within a desired level. Patients under blood pressure regulation treatment are usually in cardiac surgery or suffering from postsurgical hypertension or other cardiac diseases with abnormal arterial blood pressure. This treatment is usually performed by experienced personnel in the operation room or intensive care unit, which is very difficult and time consuming. An automatic controller that could deliver drugs based on a patient’s physiologic conditions safely and effectively without human intervention would be beneficial to both patients and medical care personnel. This article reviews various automatic control schemes that have been developed to regulate mean arterial pressure for patients with postsurgical hypertension using sodium nitroprusside proportional‐derivative‐integral controllers, adaptive controllers, rule‐based controllers, and neural‐network based controllers are common control strategies described in the literature. A brief description of each control scheme is provided, followed by examples of controller designs from the literature. Evaluations of the controller performance in computer simulation, animal studies, or clinical tests on human subjects are discussed.

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Adaptive Control of Blood Pressure

Cited by 90 publications

References 6 publications

Robust linear parameter-varying control of blood pressure using vasoactive drugs

Robust linear parameter-varying control of blood pressure using vasoactive drugs

Closed Loop Control

Blood Pressure, Automatic Control of

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