Adenocarcinoma of the Colon Presenting as Clostridium septicum Cellulitis of the Left Thigh

Poretz, Donald M.; Wood, L. D. H.; Park, C

doi:10.1097/00007611-197407000-00027

Cited by 12 publications

(2 citation statements)

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“…Interesting in this regard is the strong association in adults of C. septicum infection and colonic adenocarcinoma, particularly of the cecum and right colon [12,[14][15][16][20][21][22]. Clostridium septicum infection may, in fact, be the presenting sign of occult colon carcinoma [15,29]. Tenuous vascular supply of both malignant and benign colonic lesions may provide similar local colonic milieu to colitis-related HUS favorable to C. septicum.…”

Section: Discussionmentioning

confidence: 99%

Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome

et al. 2008

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We report the case of a 19-month-old male child with diarrhea-associated hemolytic uremic syndrome (HUS) who developed swelling of the right arm at the site of a peripherally inserted central venous catheter (PICC), fever, and later, ecchymosis. Wound cultures at the time of surgical debridement grew Clostridium septicum. The child subsequently required amputation of the right arm and prolonged therapy with parenteral penicillin and clindamycin. Clostridium septicum infections in children with HUS have been associated with a high rate of mortality. Along with colon cancer, diarrhea-associated HUS comprises a clinical entity which appears to predispose to atraumatic C. septicum infection, where acidic and anaerobic conditions in the diseased colon favor C. septicum invasion. Though not well recognized among pediatric nephrologists, C. septicum infection constitutes a severe, albeit rare, complication of diarrhea-associated HUS, but one in which a high index of suspicion is warranted as aggressive surgical and antibiotic therapy may be life-saving.

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Section: Discussionmentioning

confidence: 99%

Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome

et al. 2008

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“…When they occur, C. septicum infections result primarily from hematogenous spread, involving either primary bacteremia alone, or appearing as spontaneous soft tissue infections (or both) [2]. It is held that the gastrointestinal tract is a common point of access for C. septicum bacteremia, which may explain its close association with gastrointestinal tumors such as colon cancer [11-14]. Despite antibiotics and supportive care, disseminated C. septicum infections remain dangerous.…”

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confidence: 99%