Adipocytes in Skin Health and Disease

Rivera-Gonzalez, Guillermo C.; Shook, Brett A.; Horsley, Valerie

doi:10.1101/cshperspect.a015271

Cited by 86 publications

(70 citation statements)

References 189 publications

(222 reference statements)

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“…Adipose tissue can grow through two different mechanisms: adipogenesis or hypertrophy [13]. In this study we show that macronutrient intake may influence which pathway subcutaneous adipose tissue growth occurs and can suggest the impact this has on skin biology.…”

Section: Discussionmentioning

confidence: 64%

“…Finally, the subcutaneous fat, the deepest layer of the skin, is composed of adipocytes. This tissue has a diversity of functions including not only insulation, thermoregulation and energy storage but also immunological, inflammatory and endocrine qualities [11–13]. Evidence from mouse models [14, 15] and humans [6, 12] demonstrate that all three layers may be affected by variations in the intake of macronutrients.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice

et al. 2016

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Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous fat thickness varied positively with fat intake, due to enlarged adipocytes rather than increased adipocyte number. We therefore demonstrated clear interactions between skin structure and macronutrient intakes, with the associations being sex-specific and dependent on dietary macronutrient balance.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice

et al. 2016

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“…2,3 Moreover, this adipocyte differentiation is required for optimal wound healing with requisite myofibroblast differentiation and matrix deposition, which is substantially impaired in transgenic mice devoid of white adipose tissue. 3,26,27 However, loss of adipocytes is characteristic of dermal fibrosis such as in SSc and the BLM model. 28 To resolve this apparent paradox, we evaluated the role of FIZZ1, an inhibitor of adipocyte differentiation but an inducer of myofibroblast differentiation, in adipocyte-to-myofibroblast transdifferentiation.…”

Section: Discussionmentioning

confidence: 99%

“…25,26 Constituent adipocyte differentiation from known preadipocyte precursors involves an intricate transcriptional program that involves C/ EBPs and PPAR-g, which occurs in wound healing and certain stages of hair follicle cycling. 2,3 Moreover, this adipocyte differentiation is required for optimal wound healing with requisite myofibroblast differentiation and matrix deposition, which is substantially impaired in transgenic mice devoid of white adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Role in Dermal Fibrosis and Lipoatrophy

Martins

Santos

et al. 2015

The American Journal of Pathology

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Subcutaneous lipoatrophy characteristically accompanies dermal fibrosis with de novo emergence of myofibroblasts such as in systemic sclerosis or scleroderma. Recently dermal adipocytes were shown to have the capacity to differentiate to myofibroblasts in an animal model. Transforming growth factor b can induce this phenomenon in vitro; however its in vivo significance is unclear. Because found in inflammatory zone 1 (FIZZ1) is an inducer of myofibroblast differentiation but an inhibitor of adipocyte differentiation, we investigated its potential role in adipocyte transdifferentiation to myofibroblast in dermal fibrosis. FIZZ1 caused significant and rapid suppression of the expression of fatty acid binding protein 4 and peroxisome proliferator-activated receptor-g in adipocytes, consistent with dedifferentiation with loss of lipid and Oil Red O staining. The suppression was accompanied subsequently with stimulation of a-smooth muscle actin and type I collagen expression, indicative of myofibroblast differentiation. In vivo FIZZ1 expression was significantly elevated in the murine bleomycin-induced dermal fibrosis model, which was associated with significant reduction in adipocyte marker gene expression and subcutaneous lipoatrophy. Finally, FIZZ1 knockout mice exhibited significantly reduced bleomycin-induced dermal fibrosis with greater preservation of the subcutaneous fat than wild-type mice. These findings suggested that the FIZZ1 induction of adipocyte transdifferentiation to myofibroblast might be a key pathogenic mechanism for the accumulation of myofibroblasts in dermal fibrosis. (Am J Pathol 2015 http://dx

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“…All of them have been described in the literature as playing a role in wound healing [19,[34][35][36] . These negative study outcomes may be related to study conditions, and further research may be needed to confirm or contradict our findings.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial

Guéniche

Castiel-Higounenc²

2017

Skin Pharmacol Physiol

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Background: Glucosamine sulphate (GS) is essential in the biosynthesis of glycolipids, glycoproteins, glycosaminoglycans (GAGs), hyaluronate, and proteoglycans. Connective tissues primarily contain collagen and proteoglycans and play an important role in skin ageing. Objective: The objectives were to assess ex vivo the impact of GS on skin ageing parameters and in vivo the effect of GS on the skin physiology of mature healthy volunteers after oral intake. Methods: The impact of GS on skin ageing was assessed ex vivo via different immunohistochemical assays and histology and via a clinical study using biopsies. Modulation of selected skin physiology markers was assessed by real-time quantitative PCR on skin punch biopsies obtained from 8 healthy >50-year-old women having ingested GS 250 mg once daily for 8 weeks. Results: Ex vivo, GS significantly (all p ≤ 0.02) increased the expression of CD44 and collagen type IV, the epidermis GAG level, and collagen type I synthesis. After 8 weeks of oral GS administration, a significantly increased expression was observed at the mRNA level for vimentin, fibromodulin, biglycan, xylosyl transferase, hyaluronan synthase, collagen types I and III, bone morphogenic protein-1, and decorin (all p ≤ 0.05). Conclusion: Both experiments showed that GS has a positive effect on epidermal and dermal markers associated with age.

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Adipocytes in Skin Health and Disease

Cited by 86 publications

References 189 publications

The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice

The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice

FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Role in Dermal Fibrosis and Lipoatrophy

Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial

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