Adiponectin, visfatin and regional fat depots in normal weight obese premenopausal women

Miazgowski, Tomasz; Safranow, Krzysztof; Krzyzanowska-Swiniarska, Barbara; Iskierska, Katarzyna; Widecka, Krystyna

doi:10.1111/eci.12106

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…Compared with the gynoid pattern, the android pattern of fat distribution is considered to be more metabolically active and has been associated with increased risk of cardiovascular disease [ 19 , 20 ], abnormal lipid profiles and diastolic blood pressure [ 21 ]. It is also becoming increasingly recognized that the android pattern of fat distribution is an important determinant of the burden of musculoskeletal diseases and a recent study has shown that android fat is strongly associated with foot pain and disability [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Teichtahl

Urquhart

Wang

et al. 2016

BMC Musculoskelet Disord

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BackgroundVertebral endplate (Modic) abnormalities are important structural lesions in the spine, but their association with body composition and fat distribution have not been examined. Moreover, no study has examined whether Modic change are related to other structural features of low back pain, such as reduced intervertebral disc height.MethodsSeventy-two community-based individuals not selected for low back pain had lumbar vertebral Modic change and intervertebral disc height assessed from MRI. Dual energy x-ray absorptiometry measured body composition and fat distribution.ResultsThe predominance of Modic change was type 2. Modic change was associated with an increased fat mass index (OR 1.20, 95 % CI 1.01 to 1.43), and tended to be associated with a reduced fat-free mass index (OR 0.62, 95 % CI 0.37 to 1.03, p = 0.07). While an increased percentage of gynoid fat was associated with a reduced risk (OR 0.62, 95 % CI 0.43 to 0.89), an increased percentage of android fat was associated with an increased risk of Modic change (OR 2.11, 95 % CI 1.18 to 3.76). Modic change was also associated with reduced intervertebral disc height at L2/3, L4/5 and L5/S1 (OR range 1.4 to 1.8; all p ≤ 0.03).ConclusionModic type 2 change is associated with reduced intervertebral disc height and an increased fat mass index. Whereas gynoid fat distribution protected against Modic type 2 change, an android pattern increased the risk of this lesion. Modic type 2 change, which histologically represent fat replacement, might have a metabolic component to its aetiology.

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Section: Discussionmentioning

confidence: 99%

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Teichtahl

Urquhart

Wang

et al. 2016

BMC Musculoskelet Disord

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“…In some, a lack of association was found [13,20,23], while in others visfatin/NAMPT level was proportional [19][20][21][22][23][24][25] or even inversely related [22,26] to insulin resistance. It has been suggested that the described differences could be explained by a varied intensity of inflammation, related more to activation of monocytes circulation compared to macrophages in adipose tissue [27].…”

Section: Introductionmentioning

confidence: 99%

Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Olszanecka-Glinianowicz

Owczarek

Bożentowicz-Wikarek

et al. 2014

Metabolism

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“…Collectively, previous data has shown similar findings for trunk fat, with NWO females demonstrating higher levels. WHR data is mixed with some reporting higher ratios in NWO, [38][39][40] with others showing no difference 103,109 . The diverse outcomes displayed in this study compared to previous literature are not entirely unexpected.…”

Section: Body Compositionmentioning

confidence: 97%

The Characterization of Normal Weight Obesity in College Students

Anderson

Hirsch

Blue

et al. 2018

Medicine &Amp; Science in Sports &Amp; Exercise

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Kara Christen Anderson: The Characterization of Normal Weight Obesity in College Students (Under the direction of Abbie Smith-Ryan) The present study sought to characterize normal weight obesity (NWO) in a sample of undergraduate college students (n=94) with measures of body composition, cardiometabolic markers, and lifestyle questionnaires. Individuals were identified as NWO based on total body fat percentage (BF%) cutoffs of: NHANES 25 th BF% percentile, NHANES 50 th BF% percentile, and values established by Heo et al. Results were compared between NWO and normal weight lean (NWL) groups of the total sample, along with sex specific cohorts. Results indicated that the NWO occurrence ranged from 8-30%, with a higher occurrence in males. NWO individuals had higher fat mass, trunk fat, visceral fat, and larger waist to hip ratio than NWL. NWO also engaged in less vigorous physical activity and had fewer problems related to alcohol. It is apparent that NWO exists in a college population; more research is needed to fully understand the immediate and long-term implications of this prevalence. who volunteered their time to participate in this study. Lastly, I want to thank my advisor, Dr. Abbie Smith-Ryan, for pushing me to make this thesis the best it could be. She helped me cultivate this idea into fruition, and her guidance throughout this and all my other endeavors at UNC is much appreciated. v TABLE OF CONTENTS LIST OF TABLES .

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Adiponectin, visfatin and regional fat depots in normal weight obese premenopausal women

Abstract: Compared with healthy controls, women with NWO had higher DBP, TG, LDL, and regional fat and lower HDL. These findings seem to be associated more with excess Android fat than excess %BF.

Cited by 19 publications

References 34 publications

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height – a 3.0 T-MRI study

Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

The Characterization of Normal Weight Obesity in College Students

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