“…5 Experimentally, Shiba et al recently reported that transplantation of ADRCs showed potential for not only improving cardiac function but also electrical stability in a rat model of myocardial infarction. 6 There are also a number of animal studies demonstrating the ability of ADRCs to induce angiogenesis, lymphangiogenesis, reendothelialization and cardiac regeneration in the setting of peripheral artery disease (PAD), 7 lymphedema, 8 vascular injury, 9 and ischemic heart disease. 10 The PRECISE trial was the firstin-human trial involving myocardial injection of ADRCs for chronic ischemic heart failure.…”