Adult Wilms' Tumor: Role of Combined Modality Treatment

Mehta, Minesh P.; Langeland, Per; Bertelrud, Kathleen L

doi:10.3109/02841868909092286

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…The number of patients with adult WT metastatic to the lung has not yet been reported. A search identified 38 cases of adult WT metastatic to the lungs previously reported in the English literature (Table ) . Of note, Table lists 33 previously reported patients.…”

Section: Discussionmentioning

confidence: 99%

“…The lung is the most common site of metastasis for pediatric WT . Thirty‐eight cases of adult WT metastatic to the lung have been reported to date in the English literature (Table ) . Only two such cases have mentioned the utilization of fine needle aspiration (FNA) biopsy for initial diagnosis of the pulmonary metastasis, one of which does not describe its cytopathologic features in detail .…”

Section: Previously Reported Cases Of Adult Wilms' Tumor Metastatic Tmentioning

confidence: 99%

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Adult wilms' tumor metastatic to the lung: Endobronchial ultrasound‐guided fine needle aspiration biopsy

Perrino

Wang

Chen

et al. 2013

Diagnostic Cytopathology

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Adult Wilms' tumor (WT) is a rare entity with less than 300 cases reported to date in the medical literature. Histologic and cytologic features of adult WT of the kidney are similar to findings in pediatric WT. While the lungs are noted to be the most frequent site of metastatic disease in the pediatric population, the incidence of lung metastases remains unknown for adult WT. A search revealed 38 cases of adult WT with lung metastases published to date in the English literature. Amongst these cases only two have utilized cytology of the lung lesions as a means to arrive at a final diagnosis. We report a case of adult WT metastatic to the lung that was initially diagnosed using endobronchial ultrasound-guided fine needle aspiration biopsy. The aim is to compare the current cytologic and immunohistochemical findings with those cases previously published, to outline the cytologic features of adult WT metastatic to the lung, and to emphasize the significance of cytologic diagnosis in the work-up of adult WT.

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Section: Discussionmentioning

confidence: 99%

Section: Previously Reported Cases Of Adult Wilms' Tumor Metastatic Tmentioning

confidence: 99%

Adult wilms' tumor metastatic to the lung: Endobronchial ultrasound‐guided fine needle aspiration biopsy

Perrino

Wang

Chen

et al. 2013

Diagnostic Cytopathology

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“…Bone and brain métastasés are seldom observed and have an extremely unfavorable prognosis [13]. In 2 larger series of 29 …”

Section: Pathology and Prognostic Factorsmentioning

confidence: 99%

Wilms’ Tumor in Adults

Hentrich¹,

Hartenstein²

1995

Oncol Res Treat

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Wilms’ tumor in adults is rare and preoperative diagnosis may be difficult. Tumor stage and histology are the main determinants of outcome. Adult patients usually present with more advanced disease and the prognosis is poorer than for children. Data concerning therapy are conflicting. A multimodal procedure regardless of the stage with radical nephrectomy, chemotheray with actinomycin D, vincristine and adriamycin, and radiotherapy to the renal bed has often been recommended. However, encouraging treatment results could also be achieved by different and less aggressive treatments depending on tumor stage. Recurrencies are common in advanced disease and usually affect the lungs. Salvage chemotherapy (cisplatin/etoposide) and pulmonary radiation has been effective in some cases. Experimental approaches such as allogenic bone marrow transplantation deserve further consideration.

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