Advanced biomaterials for repairing and reconstruction of mandibular defects

Zhang, Qiang; Wu, Wei; Qian, Chunyu; Xiao, Wanshu; Zhu, Huajun; Guo, J.; Meng, Zhibing; Zhu, Jinyue; Ge, Zili; Cui, Wenguo

doi:10.1016/j.msec.2019.109858

Cited by 78 publications

(59 citation statements)

References 118 publications

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“…It is therefore deemed critical that a more effective treatment strategy to fast restore the function and morphology of the mandible is required. The ideal mandibular repair material requires macropore and micropore structures that are similar to the bone to support vascular endogenesis, proliferation of the cell, regeneration of the bone, and cytokine exchange, and secondly, it should be compatible with the defect to support mandibular activity (Kim et al, 2017;Zhang et al, 2019;Chen et al, 2020). The three-dimensional printing technology has emerged as a promising modality with considerable advantages in customizing the implants to meet diverse individual needs.…”

Section: Introductionmentioning

confidence: 99%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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Graft reconstruction of the mandible is an important approach that aims at improving the appearance and functionality of defected mandibles. The traditional implant materials are generally bioinert, non-degradable, and that they lack favorable pore structures for cell proliferation, which limit their clinical application. In this study, we used boron-containing bioactive glass which was combined with a three-dimensional (3D) printing technology to construct an osteoinductive implant scaffold, according to the imaging instructions of CT scan on bone defects. Here, the boron-containing bioglass scaffold (B-BGs) was prepared through sol-gel processing and a 3D print technique. Different boron content of borosilicate bioglass was prepared by incorporating B2O3 (molar: 19.4 and 38.8%) into 58S bioglass to replace parts of SiO2. For fabricated mandible implants through three-dimensional 3D printing of B-BGs (size: 8 × 2 mm; pore size: 250 μm) modified with borosilicate bioglass powder and sodium alginate. Notably, the compressive strength of the B-BGs was about 3.8 Mpa, which supported mandibular activity. Subsequently, the excellent biocompatibility of B-BGs was confirmed using cytotoxicity in vitro studies. Finally, data from in vivo experiments demonstrated that the B-BGs could promote bone regeneration and they could almost get completely degraded within 4 weeks. Our results showed that the boron-containing bioglass could repair mandibular defects.

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Section: Introductionmentioning

confidence: 99%

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Zhang

Yang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

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“…Opposite trends were observed for the compact and porous samples once the Gr amount is increased, as suggested by the higher micro-porosity recorded for the PP samples (as evidenced in Figure 5 ). The negative influence of a higher micro-porosity upon the shrinkage degree in the case of PP was previously discussed [ 6 ]. Apart from this, even though the actual Gr amount for the PP samples is lower due to the incorporation of Lu fibers (as detailed in the samples preparation section), the results suggested that the thermal removal of Lu is directly influencing the final dimensions of the products.…”

Section: Resultsmentioning

confidence: 99%

“…However, it was not until the beginning of the 1980s that the medical community started using and marketing calcium phosphates (mostly hydroxyapatite, HA, Ca 10 (PO 4 ) 6 (OH) 2 ) for restorative dental procedures and bone defect repair [ 1 , 3 ]. The ongoing need for advanced bone surgical procedures and bone-mimicking structures is directly correlated with the increase of the elderly population and, thereby, with the frequency upsurge of cases when bone is unable to repair itself (i.e., associated pathological conditions, large defects caused by severe traumas or tumor resections) [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

et al. 2021

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A successful bone-graft-controlled healing entails the development of novel products with tunable compositional and architectural features and mechanical performances and is, thereby, able to accommodate fast bone in-growth and remodeling. To this effect, graphene nanoplatelets and Luffa-fibers were chosen as mechanical reinforcement phase and sacrificial template, respectively, and incorporated into a hydroxyapatite and brushite matrix derived by marble conversion with the help of a reproducible technology. The bio-products, framed by a one-stage-addition polymer-free fabrication route, were thoroughly physico-chemically investigated (by XRD, FTIR spectroscopy, SEM, and nano-computed tomography analysis, as well as surface energy measurements and mechanical performance assessments) after sintering in air or nitrogen ambient. The experiments exposed that the coupling of a nitrogen ambient with the graphene admixing triggers, in both compact and porous samples, important structural (i.e., decomposition of β-Ca3(PO4)2 into α-Ca3(PO4)2 and α-Ca2P2O7) and morphological modifications. Certain restrictions and benefits were outlined with respect to the spatial porosity and global mechanical features of the derived bone scaffolds. Specifically, in nitrogen ambient, the graphene amount should be set to a maximum 0.25 wt.% in the case of compact products, while for the porous ones, significantly augmented compressive strengths were revealed at all graphene amounts. The sintering ambient or the graphene addition did not interfere with the Luffa ability to generate 3D-channels-arrays at high temperatures. It can be concluded that both Luffa and graphene agents act as adjuvants under nitrogen ambient, and that their incorporation-ratio can be modulated to favorably fit certain foreseeable biomedical applications.

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“…Recently, great advances had been reached in the development of new biomaterials, and researchers noticed that some of the artificial biomaterials might be the ideal strategies to treat bone defects. 11,12 Specifically, a new type of biocompatible material, hydrogel, is characterized by both solid and fluid properties, which has three-dimensional network structure as a stable, soft and elastic functional polymer in water, and has a strong function of water locking and can hold more than 90% of water in it, [13][14][15] the above properties made hydrogel as an ideal agent for tissue engineering 16,17 and local drug delivery system [18][19][20][21] in bone defect treatment. The commonly used hydrogel materials included polyethylene glycol two acrylate (PEGDA) and its derivatives, methacrylate modified dextran, HA and its derivatives, etc.…”

Section: Introductionmentioning

confidence: 99%

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Liu

Jing

et al. 2021

J Biomater Appl

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Scaffolds with osteogenic differentiation function play an important role in the healing process of bone defects. Here, we designed a high strength Poly(ethyleneglycol) diacrylate/Hydroxyapatite (PEGDA/HA) mineralized hydrogel loaded with Exendin4 for inducing osteogenic differentiation. In this study, PEGDA hydrogel was prepared by photo initiating method. PEGDA/HA mineralized hydrogel was prepared by in-situ precipitation method, and Exendin4 was loaded by gel adsorption. The effects of different calcium and phosphorus concentrations on the strength and Exendin4 release of PEGDA/HA hydrogels were investigated. Rat models of bone defect were made and randomly divided into 5 groups. The experimental group was implanted with PEGDA hydrogel, Exendin4-PEGDA hydrogel, PEGDA/HA mineralized hydrogel, Exendin4-PEGDA/HA mineralized hydrogel, and no materials were implanted in the blank control group. Computed tomography (CT) and histology were observed 4 and 8 weeks after operation. Our results revealed that the PEGDA/HA mineralized hydrogel had porous structure, high mechanical strength and good biocompatibility. In vitro release test showed that the mineralized hydrogel exhibited good sustained release profile within 20 d. The animal experiments showed that the mineralized hydrogel accelerated the formation of new bone after 4 and 8 weeks, and formed a seamless union on the defected bone area after 8 weeks. In conclusions, The Exendin4-PEGDA/HA mineralized hydrogel can effectively repair bone defects in rats, and it is expected to be used as a biomaterial for human bone tissue repair.

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Advanced biomaterials for repairing and reconstruction of mandibular defects

Cited by 78 publications

References 118 publications

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction

Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

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