Advanced Quality Assurance for CNAO

Amaldi, U.; Hajdas, W.; Iliescu, S.; Malakhov, N.; Samarati, J.; Sauli, F.; Watts, D.

doi:10.1016/j.nima.2009.06.087

Cited by 42 publications

(35 citation statements)

References 4 publications

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“…Secondary ions have been suggested as a radiation modality to be investigated for ion beam therapy monitoring [12], [13]. While the unfragmented primary carbon ions stop in the target volume, secondary ions may leave the patient.…”

Section: B Non-invasive Monitoring Of the Beam In The Patientmentioning

confidence: 99%

Study of the capabilities of the Timepix detector for Ion Beam radiotherapy applications

Martišíková

Hartmann

Gwosch

et al. 2012

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)

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The finite range of ion beams in matter and the presence of the Bragg-peak at the end of their range enable to create highly localized dose distributions. This advantage represents at the same time a challenge -namely to control all factors influencing the dose distribution with high precision.To ensure the required quality of the dose distribution applied to the patient, a number of measurement procedures is conducted.Many of these techniques were adopted from photon beam radiotherapy. Improvements in terms of the information amount gained are expected from new generations of dedicated ion detec tion techniques. One of the possible research directions is given by semiconductor-based detectors, which are at present rarely used in ion beam radiotherapy. In this contribution we report on the studies of the capabilities of the Timepix detector. This hybrid semiconductor pixelated detector was developed by the Medipix Collaboration at CERN. Its high spatial resolution allows an online registration of single ions. Experiments were performed at the Heidelberg Ion Beam Therapy Center in Germany using carbon ion beams. The signal pattern of single ions in the detector signal was shown to provide separation of the primary and different types of secondary ions. The direction of the secondary ions emerging from different irradiated phantoms were measured using 3D voxel detector containing several Timepix layers. The analysis of the recorded ion tracks shows a correlation with the beam range, position and width, which are all of high interest for monitoring of the beam within the patient during the therapy delivery. The results of the discussed studies show that the Timepix detector offers attractive capabilities for the needs of carbon ion beam therapy.

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Section: B Non-invasive Monitoring Of the Beam In The Patientmentioning

confidence: 99%

Study of the capabilities of the Timepix detector for Ion Beam radiotherapy applications

Martišíková

Hartmann

Gwosch

et al. 2012

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)

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“…One modality, which has already proven its clinical applicability, is the registration of the emission point of 511 keV annihilation radiation following a β + -decay, by using positron emission tomography (PET) [1,2,3]. In the case of carbon ion treatment, tracking of emitted light charged fragments can be used for a reconstruction of the primary interaction vertex [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

Krimmer

Ley

Abellán

et al. 2015

Nuclear Instruments and Methods in Physics Research Section A:

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International audienceA Compton camera is being developed for the purpose of ion-range monitoring during hadrontherapy via the detection of prompt-gamma rays. The system consists of a scintillating fiber beam tagging hodoscope, a stack of double sided silicon strip detectors (90 Â 90 Â 2 mm 3 , 2 Â 64 strips) as scatter detectors, as well as bismuth germanate (BGO) scintillation detectors (38 Â 35 Â 30 mm 3 , 100 blocks) as absorbers. The individual components will be described, together with the status of their characterization

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“…In order to reduce these margins and deliver a safer treatment, a device for the real-time monitoring of the range inside the patient would be useful. Several techniques have been explored for this purpose: PET monitoring which was used off line [3] and on line [2], the use of other two types of secondary particles emerging from patient, (i) prompt gamma [4][5] and charged particles, in particular protons (for carbon beams) [6] [7]. The present paper focuses on proton imaging (IVI method) in the frame of the QAPIVI (Quality Assurance by Protons Vertex Imaging) project.…”

Section: Introductionmentioning

confidence: 99%