Advances in Indolizine Chemistry

One-pot Synthesis of 3-Aryl-substituted 1-Hydroxy-2-acylindolizines

“…Monomorine I [9], pumiliotoxines [10], and tashiromine [11] represent characteristic examples of this substance class. For these applications of indolizines a well-defined substitution pattern is required and has been the target of diverse research efforts for the construction of substituted indolizines [5,12,13]. Therefore, different transition metal-mediated and metal-free strategies for the synthesis of substituted indolizines were investigated over the last years [13 -23].…”

Pyrrolo[1,2-b]pyridazines. A revisit

“…The Chichibabin reaction. The Chichibabin reaction [20][21][22][23] is one of the general synthetic methods for obtaining indolizines and implies the N-alkylation of 2-substituted pyridines with an α-halogenated carbonyl compound, followed by the intramolecular cyclization in the presence of a weak base, the most commonly used being sodium bicarbonate. The method was successfully applied for other 2-substituted nitrogen containg aromatic heterocycles.…”

Synthesis and Biological Evaluation of Novel 6-(3-(4,5-Dihydro-1,5-diphenyl-1<i>H</i>-pyrazol-3-yl)phenylamino) Pyridazin-3(2H)-one Derivatives

“…Nitrogen heterocycles are of synthetic interest because they constitute an important class of natural and synthetic products, many of which exhibited useful biological activities [1]. An interest in five member systems with two adjacent nitrogen atoms occurs from saturated and partially saturated pyrazoles in biologically active compounds and natural products [2,3].…”