Advances in the application of nanotechnology in reducing cardiotoxicity induced by cancer chemotherapy

Su, Xin; Zhang, Xiaoyu; Liu, Wenjing; Yang, Xinyu; An, Na; Yang, Fan; Sun, Jiahao; Xing, Yanwei; Shang, Hongcai

doi:10.1016/j.semcancer.2021.08.003

Cited by 24 publications

(20 citation statements)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteosarcoma is a malignant tumour with a very high mortality rate in adolescents, and available effective treatments are very limited. Neoadjuvant chemotherapy can prolong the survival of patients, but the resistance of osteosarcoma to chemotherapy drugs is still a major problem today (Li and Ma, 2021;Su et al, 2021). Cis, Dox, and Mtx are the current routine chemotherapy drugs for osteosarcoma in clinical practice, and the decreased sensitivity of osteosarcoma to these drugs leads to the occurrence of drug resistance, which is the main challenge to improve the overall survival of patients (Wang Y. et al, 2018;Xiao et al, 2018;Chen R. et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma

Tang

Wei

Tian

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

One contributor to the high mortality of osteosarcoma is its reduced sensitivity to chemotherapy, but the mechanism involved is unclear. Improving the sensitivity of osteosarcoma to chemotherapy is urgently needed to improve patient survival. We found that chemotherapy triggered apoptosis of human osteosarcoma cells in vitro and in vivo; this was accompanied by increased Sestrin2 expression. Importantly, autophagy was also enhanced with increased Sestrin2 expression. Based on this observation, we explored the potential role of Sestrin2 in autophagy of osteosarcoma. We found that Sestrin2 inhibited osteosarcoma cell apoptosis by promoting autophagy via inhibition of endoplasmic reticulum stress, and this process is closely related to the PERK-eIF2α-CHOP pathway. In addition, our study showed that low Sestrin2 expression can effectively reduce autophagy of human osteosarcoma cells after chemotherapy, increase p-mTOR expression, decrease Bcl-2 expression, promote osteosarcoma cell apoptosis, and slow down tumour progression in NU/NU mice. Sestrin2 activates autophagy by inhibiting mTOR via the PERK-eIF2α-CHOP pathway and inhibits apoptosis via Bcl-2. Therefore, our results explain one underlying mechanism of increasing the sensitivity of osteosarcoma to chemotherapy and suggest that Sestrin2 is a promising gene target.

show abstract

Section: Discussionmentioning

confidence: 99%

Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma

Tang

Wei

Tian

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The good news is that emerging new technologies provide new solutions. Through quantum computing, microfluidics, molecular docking, and other technologies, researchers use combinatorial methods to take advantage of the therapeutic properties of NPPs while studying their molecular effects under physiological conditions [ 181 – 184 ]. Among them, molecular docking has become an important tool of the drug discovery process [ 185 ].…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury and Application of Natural Plant Products

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Ischemic heart disease (IHD) is currently one of the leading causes of death among cardiovascular diseases worldwide. In addition, blood reflow and reperfusion paradoxically also lead to further death of cardiomyocytes and increase the infarct size. Multiple evidences indicated that mitochondrial function and structural disorders were the basic driving force of IHD. We summed up the latest evidence of the basic associations and underlying mechanisms of mitochondrial damage in the event of ischemia/reperfusion (I/R) injury. This review then reviewed natural plant products (NPPs) which have been demonstrated to mitochondria-targeted therapeutic effects during I/R injury and the potential pathways involved. We realized that NPPs mainly maintained the integrality of mitochondria membrane and ameliorated dysfunction, such as improving abnormal mitochondrial calcium handling and inhibiting oxidative stress, so as to protect cardiomyocytes during I/R injury. This information will improve our knowledge of mitochondrial biology and I/R-induced injury’s pathogenesis and exhibit that NPPs hold promise for translation into potential therapies that target mitochondria.

show abstract

“…In recent years, advancement in nanotechnology research has grown exponentially. These increasingly important nanomaterials are made up of nanoparticles (NPs) smaller than 100 nanometers, giving rise to a wide field of applications in biomedicine [1][2][3][4][5], the food industry [6,7], environmental bioremediation [8][9][10][11], energy storage [12], aquaculture [13], and more. These increasing applications have generated a change of direction in research for the development of profitable and environmentally friendly technologies [14].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Superparamagnetic Iron Oxide Nanoparticles with Eucalyptus globulus Extract and Their Application in the Removal of Heavy Metals from Agricultural Soil

et al. 2022

View full text Add to dashboard Cite

The green synthesis of metal oxide nanoparticles is presented as an excellent sustainable alternative for achieving nanostructures, with potential applications. This research provides important information regarding the influence of the type of solvent used in extracting organic reducing agents from E. globulus on the FeO NPs green synthesis protocol. A broad approach to characterization is presented, where UV-vis spectrophotometry suggests the presence of this type of nanoparticulate material. Likewise, the reduction mechanism was evaluated by FT-IR and the magnetic properties were evaluated by PPSM. In addition, characterizations were linked via elemental analysis (EDX), crystallographic characterization (XRD), electron microscopy (SEM/STEM), and Z potential to evaluate colloidal stability. The results show the influence of the type of solvent used for the extraction of organic reducing agents from E. globulus, and the effect on the synthesis of FeO NPs. In addition, the nanostructure material obtained showed excellent efficiency in the remediation of agricultural soil, eliminating metals such as Cr-VI, Cd, and, to a lesser extent, Pb.

show abstract

Advances in the application of nanotechnology in reducing cardiotoxicity induced by cancer chemotherapy

Cited by 24 publications

References 203 publications

Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma

Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma

Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury and Application of Natural Plant Products

Green Synthesis of Superparamagnetic Iron Oxide Nanoparticles with Eucalyptus globulus Extract and Their Application in the Removal of Heavy Metals from Agricultural Soil

Contact Info

Product

Resources

About