Adverse reproduction outcomes among employees working in biomedical research laboratories

Wennborg, Helena; Bonde, Jens Peter; Stenbeck, Magnus; Olsen, Jørn

doi:10.5271/sjweh.640

Cited by 62 publications

(35 citation statements)

References 25 publications

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“…Most of the epidemiologic evidence of the effects of organic solvent exposure on fetal growth and duration of pregnancy comes from studies focusing on specific occupational groups including laboratory workers (Axelsson et al, 1984;Taskinen et al, 1994;Wennborg et al, 2000Wennborg et al, ,2002Zhu et al, 2006), drycleaners (Olsen et al, 1990), pharmacy assistants (Schaumburg and Olsen, 1991), hairdressers (Kersemaekers et al, 1997) and workers in petrochemical industry (Ha et al, 2002). The results of these studies are inconsistent.…”

Section: Synthesis With Previous Knowledgementioning

confidence: 70%

“…There is also some evidence of an increased risk of preterm delivery related to exposure to organic solvents in laboratory work (Wennborg et al, 2002) and work in medicine and science (Savitz et al, 1989). Two population-based studies conducted in California (Lipscomb et al, 1991) and Germany (Seidler et al, 1999) provided suggestive evidence of an increased risk of low birth weight and preterm delivery (Lipscomb et al, 1991) and small-for-gestational-age (Seidler et al, 1999) related to occupational organic solvent exposure.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to organic solvents and adverse pregnancy outcomes

Ahmed

Jaakkola

2007

Human Reproduction

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BACKGROUND: Organic solvents are among the most common exposures in the workplace. Our objective was to elaborate the relationship between prenatal occupational solvent exposure and fetal growth as well as duration of pregnancy, and to quantify the impact of occupational organic solvent exposure. METHODS: We conducted a population-based study of 1670 singleton newborns of women who participated in The Finnish Prenatal Environment and Health Study after their delivery (response rate 94%) and who were working during pregnancy (65%). Exposure information was based on questions about exposure to solvents at work before and during pregnancy. The health outcomes, based on information from a questionnaire and the Finnish Medical Birth Registry, were low birth weight (<3000 g), small-for-gestational-age and preterm delivery (<37 weeks). RESULTS: In logistic regression analysis, the risk of the baby being small-for-gestational-age was related to any exposure to solvents 3 months before or during pregnancy with an adjusted odds ratio (OR) of 1.67 [95% confidence interval (CI) 5 1.02-2.73]. Also the adjusted OR for low birth weight was elevated with exposure, although it did not reach statistical significance (1.17; 95% CI 5 0.71-1.93). The population attributable fraction for small-for-gestational-age was 2.3% for all pregnant women. CONCLUSIONS: Work exposure to organic solvents may reduce intrauterine growth by increasing the risk of the baby being small-for-gestational-age.

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Section: Synthesis With Previous Knowledgementioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Exposure to organic solvents and adverse pregnancy outcomes

Ahmed

Jaakkola

2007

Human Reproduction

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“…Work with chemicals in general, and laboratory work in particular, has, in some epidemiologic studies, shown high risks for adverse pregnancy outcomes (eg, spontaneous abortion, malformation, preterm birth, and reduced fecundity) (1)(2)(3)(4). Laboratory work has also been associated with an increased risk of lymphatic and hematopoietic neoplasm, brain tumor, and breast cancer (5,6).…”

mentioning

confidence: 99%

Time to pregnancy among Danish laboratory technicians who were a part of the National Birth Cohort

Knudsen¹,

Andersen²,

Hjøllund³

et al. 2005

Scand J Work Environ Health

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“…Many studies support the positive association between the exposure to laboratory work with organic solvents and occurrence of dose-related neurotoxic symptoms (5), increased risk of some reproductive outcomes (especially preterm and posterm births) among women performing certain laboratory tasks (6), increased risk of spontaneous abortion among pregnant women (7,8), and increased risk of lymphohaematopoietic cancer (leukemia and lymphomas) in men and women alike (9). Reduction of human exposure to organic solvents is one of the main objectives of hygienists, public authorities, World Health Organization, U.S.…”

mentioning

confidence: 99%

A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs

Darwish¹,

Mahmoud²,

Al-Majed³

2010

Acta Pharmaceutica

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The present study describes the development of a novel analytical approach that can reduce by 50-fold the consumption of organic solvents in the charge transfer (CT)--based spectrophotometric analysis. The proposed approach employed 96-microwell assay plates for carrying out the reaction. The CT reaction between the electron--donating analyte and electron-accepting reagent was performed in microwells (200-mL of organic solvent) and the color signals were measured with a microwell-plate reader. Optimum conditions for the proposed approach were established for two antihypertensive drugs, namely ramipril (RML) and lisinopril (LSL) as model compounds for the electron-donating analytes, and 2,3-dichloro-5,6--dicyano-1,4-benzoquinone (DDQ) as a p-electron acceptor. Under the optimum conditions, Beer's law was obeyed in the concentration range of 6-100 and 6-60 mg mL -1 for RML and LSL, respectively. The limits of detection were 0.97 and 1.10 mg mL -1 for RML and LSL, respectively. The precision of the methods was satisfactory; the values of relative standard deviations did not exceed 1.1 %. The proposed approach was successfully applied to the analysis of pharmaceutical dosage forms with good accuracy and precision. The results were comparable with those of the reported methods. The approach described herein is of great practical value in pharmaceutical analysis because it reduces the exposure of analysts to the toxic effects of organic solvents, lowers the analysis cost by 50-fold, and it has a high throughput property. Although the approach was validated for RML and LSL, the same methodology could be used for any electron-donating analyte for which a CT-reaction can be performed.

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Adverse reproduction outcomes among employees working in biomedical research laboratories

Cited by 62 publications

References 25 publications

Exposure to organic solvents and adverse pregnancy outcomes

Exposure to organic solvents and adverse pregnancy outcomes

Time to pregnancy among Danish laboratory technicians who were a part of the National Birth Cohort

A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs

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