Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression

Park, Young-Min; Erickson, Christopher B.; Bessesen, Dan; Pelt, Rachael E. Van; Cox-York, Kimberly

doi:10.1016/j.steroids.2017.03.001

Cited by 34 publications

(29 citation statements)

References 25 publications

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“…In general, men showed greater accumulation of visceral fat and greater age‐related decreases in leg fat than women; however, this difference decreased when older males were compared with postmenopausal females . A retrospective cohort study by Park et al, which enrolled premenopausal and postmenopausal normal weight women with similar total fat mass, highlighted that increased age was associated with lower ERα and a decreased balance of ERα to ERβ in abdominal and femoral subcutaneous adipose tissue . Combined with the results of this study, we might speculate a possible pathophysiological mechanism to explain why premenopausal women seemed to be protected against cardiovascular morbidity and mortality in comparison with men of similar age or postmenopausal women…”

Section: Discussionsupporting

confidence: 72%

Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome

Kao

Chen

et al. 2019

Diabetes Metabolism Res

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Objective: To elucidate whether the peripheral fat (PF)-combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause-specific mortality than the common MetS. Methods: Data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including waist circumference MetS (WCMetS), PFMetS, and PF-combined definition of MetS. The main outcome was to evaluate the predictive ability of the newly defined MetS for time to cause-specific mortality. The secondary outcomes were the relationships between the PF percentage and C-reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA-IR) to clarify the gender discrepancy. Results: For cardiovascular mortality, the adjusted hazard ratios for WCMetS, PFMetS, and PF-combined definition MetS were 1.867, 1.742, and 2.117, respectively (all P < 0.001). A positive association between PF percentage and CRP in men and a negative correlation between PF percentage and HOMA-IR in women after adjustment for all variates were found. Conclusions:The PF-combined definition of MetS had a stronger predictive ability for all-cause and cardiovascular mortality than general MetS. Notably, the PF might have differential gender-specific health effects on cardiovascular events.

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Section: Discussionsupporting

confidence: 72%

Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome

Kao

Chen

et al. 2019

Diabetes Metabolism Res

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“…These data suggest, that the ERs regulate VEGFA in an opposite way. It is known that the decline of E2 levels in postmenopausal women is associated with reductions of ESR1 expression, as well as there is a change in ESR1/ESR2 ratio such that there is more ESR2 relative to ESR1 45 . In addition, the postmenopausal period is characterized by increased visceral adiposity and enhanced metabolic risks associated with obesity 46 , which may reflect either the reductions in E2 and/or ESR1 expression, and their relative impact on VEGFA.…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue

Fátima

Campello

Santos

et al. 2017

Sci Rep

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Vascular endothelial growth factor A (VEGFA) is a key factor in the regulation of angiogenesis in adipose tissue. Poor vascularization during adipose tissue proliferation causes fibrosis and local inflammation, and is associated with insulin resistance. It is known that 17-beta estradiol (E2) regulates adipose tissue function and VEGFA expression in other tissues; however, the ability of E2 to regulate VEGFA in adipose tissue is currently unknown. In this study, we showed that, in 3T3-L1 cells, E2 and the estrogen receptor 1 (ESR1) agonist PPT induced VEGFA expression, while ESR1 antagonist (MPP), and selective knockdown of ESR1 using siRNA decreased VEGFA and prevented the ability of E2 to modulate its expression. Additionally, we found that E2 and PPT induced the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the VEGFA gene promoter. We further found that VEGFA expression was lower in inguinal and gonadal white adipose tissues of ESR1 total body knockout female mice compared to wild type mice. In conclusion, our data provide evidence of an important role for E2/ESR1 in modulating adipose tissue VEGFA, which is potentially important to enhance angiogenesis, reduce inflammation and improve adipose tissue function.

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“…Earlier studies have shown that there was an inverse link between age and gene expression for ERα and the ratio of ERα to ERβ in female abdominal subcutaneous fatty tissue [35]. Some researchers have found that the prevalence of obesity varies not only by age but also by income and educational levels [36,37].…”

Section: Characteristics Of Participantsmentioning

confidence: 99%

Association between sleep quality and central obesity among southern Chinese reproductive-aged women

Liu

Guo

et al. 2020

Preprint

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Background Females are more prone to complain about sleep problems. Poor sleep quality in this group may make them more vulnerable to suffering obesity and other diseases, which can seriously affect their fitness and quality of life. Nevertheless, the connections between sleep quality and central obesity among reproductive-aged women are not clear. The aims of this study were to explore the association between sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) and central obesity among Chinese reproductive-aged women and to identify the independent contributions of sociodemographic characteristics, health-related factors, and sleep quality to central obesity. Methods In this cross-sectional survey, 2449 Chinese reproductive-aged women aged 18-49 years were studied. Sleep quality was assessed using the Chinese version of the PSQI. Central obesity as the outcome of interest was a binary variable; women were categorized as with versus without central obesity. Clustered logistic regression was used to analyze the independent contribution of sleep quality to central obesity.Results The risk of central obesity increased significantly with poor sleep quality (assessed by global PSQI score) (adjusted OR(Odds Ratio)=2.20 per SD increase; P=0.004), increased sleep disturbance score (adjusted OR=1.11 per SD increase; P=0.042) and decreased subjective sleep quality score (adjusted OR=0.81 per SD increase; P<0.001). The independent contribution of sleep quality was 9.9%, less than those of sociodemographic (73.3%) and health-related (16.8%) variables. Among complaints related to sleep disturbance, the inability to breathe comfortably and having bad dreams showed significant associations with central obesity. Conclusions There exists some degree of correlation between sleep quality and central obesity amongChinese reproductive-aged women. Understanding this link has public health relevance because of the important role sleep plays in health. It also has some implications for the discovery of novel strategies to prevent central obesity and the implementation of weight maintenance programs in this population group.

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Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression

Cited by 34 publications

References 25 publications

Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome

Peripheral fat distribution versus waist circumference for predicting mortality in metabolic syndrome

Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue

Association between sleep quality and central obesity among southern Chinese reproductive-aged women

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