Age of onset of puberty in urban Argentinian children

Lejarraga, Horacio; Cusminsky, Marcos; Castro, Elsa P.

doi:10.1080/03014467600001601

Cited by 16 publications

(10 citation statements)

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“…It has been reported that somatotropin deficiency is associated with delayed onset of sexual maturation [4,11]. In our group of patients who developed spontaneously, the onset of puberty was delayed by an average of 3.2 years compared to normal Argentinian children [12] and 3.4 years compared to British children [13]. In patients who develop spontaneously, once puberty starts, it follows the same pattern as in normal boys.…”

Section: Discussionsupporting

confidence: 70%

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Pubertal development in male hypopituitarism

et al. 1986

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The spontaneous or therapeutically induced pubertal development of 65 male patients with idiopathic hypopituitarism was analysed. Spontaneous puberty occurred in 82% of the patients with prepubertal isolated growth hormone deficiency and in 32.5% of those with impairment in the secretion of more than one pituitary hormone. Out of this group, 36 patients could be studied longitudinally. In 15 patients, the onset of spontaneous puberty was delayed, on average, 3.2 years. It started at a bone age of 10.36 +/- 1.25 "years" and followed a pattern similar to that of normal boys. Testosterone levels at each pubertal stage were not different from those of normal boys. Mean peak height velocity reached 7.27 +/- 1.82 cm/year. In 21 patients with gonadotropin deficiency, hCG treatment was started at a chronological age of 19.04 +/- 2.17 years and a bone age of 12.94 +/- 0.80 "years". Plasma testosterone attained normal adult levels in the majority of boys, while the development of sexual characteristics showed a wide variation. Mean growth velocity during the first year of hCG therapy reached 6.11 +/- 2.47 cm/year. Partial gonadotropin deficiency was diagnosed in two boys. Although testosterone seems today to be, for practical reasons, the replacement therapy of choice, hCG treatment is an alternative for hypopituitary patients with absent gonadotropin function.

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Section: Discussionsupporting

confidence: 70%

“…Two of them attained an incomplete degree of sexual development. The mean age for the onset of spontaneous puberty was 14.99 + 1.11 (Table 2), delayed when compared to the mean of 11.8 • 1.44 years in a group of normal Argentin• children [12].…”

Section: Initiation Of Sexual Developmentmentioning

confidence: 94%

Pubertal development in male hypopituitarism

et al. 1986

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“…According to Ferguson-Smith (1965) spontaneous menses occurred in only 8o7o of patients with 45X karyotype and in 17-21°70 of those with mosaicism. In our girls with spontaneous menarche, puberty and menarche started 1 year later than normal girls in Argentina (Lejarraga et al 1976). We found a small, although non-significant, difference in final height in favour of spontaneous menarche patients: 139.2 versus 137-9 for the total sample.…”

Section: Discussionmentioning

confidence: 87%

“…The onset of spontaneous puberty in these patients took place at a mean age of ll.8SD 1-Tyears (range 9.6-14-0years) and menarche occurred at 13.6SD 1.5years (range 11-16.1 years). Both pubertal events were 1 year delayed with regard to the Argentine normal population values (Lejarraga, Castro andCuminsky 1976, Lejarraga, Sanchirico andCusminsky 1980). Two of these 17 patients had a karyotype Ann Hum Biol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/01/14…”

Section: Resultsmentioning

confidence: 92%

Growth of Argentinian girls with Turner syndrome

Garcia-Rudaz

Martínez

Heinrich

et al. 1995

Annals of Human Biology

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Growth data on 254 patients with Turner syndrome from Argentina-120 with XO karyotype and 134 with other chromosomal abnormalities-were analysed. Birth weight and height were significantly reduced. Ninety patients had received oestrogen treatment from a mean age of 14-0 years (SD 1.2) and 17 patients had spontaneous menarche. Patients who underwent spontaneous menarche had a small growth spurt. Final height was slightly higher (139.8 cm SD 5.6), though not significantly different from the mean adult height of the whole sample (137.9 cm SD 5.7). Mean adult height was 3.73 SD below mean of the normal local population. Mean height velocities from birth to maturity are very similar to those found in other samples. Distance standards were prepared by fitting a fifth-degree polynomial to the interpolated mean heights at each 0.5 year of age, and to the raw SD. Selected centiles were then calculated from the smoothed values. Differences between adult height in local Turner syndrome girls and local normal population are very similar to the same Turner-normal differences described in other communities. Standards presented here are useful for evaluating Turner syndrome patients from Argentina, and may also be used by those with similar growth pattern in their normal population.

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“…In a previous study carried out in the same city (Lejarraga and Cusminsky 1976), it was shown that the age of onset of puberty in local middle-class children is in about the middle of the range of.world variability. Hence, there is a contrast between age of onset of puberty and age ofmenarche, when local figures are compared to world variation.…”

Section: Resultsmentioning

confidence: 96%