2003
DOI: 10.1046/j.1474-9728.2003.00049.x
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Age of ovary determines remaining life expectancy in old ovariectomized mice

Abstract: SummaryWe investigated the capacity of young ovaries, transplanted into old ovariectomized CBA mice, to improve remaining life expectancy of the hosts. Donor females were sexually mature 2-month-olds; recipients were prepubertally ovariectomized at 3 weeks and received transplants at 5, 8 or 11 months of age. Relative to ovariectomized control females, life expectancy at 11 months was increased by 60% in 11-month recipient females and by 40% relative to intact control females. Only 20% of the 11-month transpla… Show more

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Cited by 128 publications
(104 citation statements)
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“…Substantial research has been devoted to identifying the mechanisms involved, especially in the nematode worm Caenorhabditis elegansi (Kimura et al 1997;Lakowski and Hekimi 1998;Dillin et al 2002), the fruit fly Drosophila melanogaster (Chapman and Partridge 1996;Clancy et al 2001;Mair et al 2003;Marden et al 2003), and the mouse Mus musculus (Hursting et al 1994;Bluher et al 2003;Harrison et al 2009). Insights into mechanisms underpinning the effects of DR on life span have come from studies drawing on several key techniques including gene mutations (e.g., Kimura et al 1997;Clancy et al 2001;Marden et al 2003), manipulations of reproduction (e.g., Hsin and Kenyon 1999;Cargill et al 2003;Mair et al 2004), and sophisticated dietary approaches (e.g. Bateman and Sonleitner 1967;Carey et al 1998;Mair et al 2003;Grandison et al 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Substantial research has been devoted to identifying the mechanisms involved, especially in the nematode worm Caenorhabditis elegansi (Kimura et al 1997;Lakowski and Hekimi 1998;Dillin et al 2002), the fruit fly Drosophila melanogaster (Chapman and Partridge 1996;Clancy et al 2001;Mair et al 2003;Marden et al 2003), and the mouse Mus musculus (Hursting et al 1994;Bluher et al 2003;Harrison et al 2009). Insights into mechanisms underpinning the effects of DR on life span have come from studies drawing on several key techniques including gene mutations (e.g., Kimura et al 1997;Clancy et al 2001;Marden et al 2003), manipulations of reproduction (e.g., Hsin and Kenyon 1999;Cargill et al 2003;Mair et al 2004), and sophisticated dietary approaches (e.g. Bateman and Sonleitner 1967;Carey et al 1998;Mair et al 2003;Grandison et al 2009).…”
Section: Introductionmentioning
confidence: 99%
“…It is now well established that the exhaustion of the ovarian follicle numbers over time is responsible for menopause (reproductive aging and failure), and women having higher ovarian reserve have longer reproductive lifespans (Wallace and Kelsey, 2004). When young ovaries were transplanted to old post-reproductive mice, their reproductive function was restored for a while (Cargill et al, 2003). This example illustrates a general idea that aging largely occurs because of cell loss, which starts early in life.…”
Section: Decline In Systems' Redundancy With Agementioning
confidence: 85%
“…For lifespan, convergence decreases cumulation of mutations and in general, increases mutational robustness; for developmental rates, they are the direct result of decreased replication and transcription rates because of increased collision frequencies between replication and transcription forks. It is notable that this rationale yields a molecular mechanism for the well known negative association between metabolic rates and longevities, as described in Insects (Antler flies, Bonduriansky & Brassil, 2005;Drosophila, Marden et al, 2003;Novoseltsev et al, 2005;Mockett & Sohal, 2006), nematodes (Jenkins et al, 2004;Chen et al, 2007;Lee et al, 2006;Hughes et al, 2007) and mice (Cargill et al, 2003;and others, Bonsall, 2006). Some ecological data explaining the tradeoffs exist (Bonduriansky & Brassil, 2005), and results suggest the tradeoff is due to dietary metabolism (Partridge et al, 2005a,b;Speakman, 2005a,b;Kaeberlein et al 2006;Ruggiero & Ferrucci, 2006;Szewczyk et al, 2006;Wolkow & Iser, 2006).…”
Section: Rates Of Development and Convergence Between Replication Andmentioning
confidence: 92%