Age-Related Blood Antioxidant Capacity in Men and Women

Hϋbner-Woźniak, Elżbieta; Okęcka-Szymańska, Joanna; Stupnicki, Romuald; Malara, Marzena; Kozdroń, Ewa

doi:10.2478/v10011-011-0008-4

Cited by 14 publications

(13 citation statements)

References 28 publications

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“…There was also no signifi cant difference in TAC values between male and female dogs. Most of the studies in healthy humans showed a signifi cant decline of TAC levels with age [20,[46][47][48]. Moreover, signifi cantly lower TAC values were found in older men than in young men, but no such difference was found in women [46][47][48].…”

Section: Discussionmentioning

confidence: 98%

Plasma Total Antioxidant Capacity and Activities of Blood Glutathione Peroxidase and Superoxide Dismutase Determined in Healthy Dogs by Using Commercially Available Kits

et al. 2016

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Data on the values of selected blood antioxidant parameters, i.e. total antioxidant capacity, glutathione peroxidase, and superoxide dismutase in healthy dogs, are lacking. There are no published accepted standard reference methods for their determination. The aim of this study was to determine the values of plasma total antioxidant capacity and the activities of whole blood glutathione peroxidase and erythrocyte superoxide dismutase in 30 healthy client-owned dogs (19 females, 11 males). The effect of age and sex on the measured antioxidant parameters was also investigated. Antioxidant parameters were determined with an automated biochemical analyser, using the commercially available Randox kits. No signifi cant difference in age, weight, and antioxidant parameters was determined between females and males. A signifi cant positive effect of age (p = 0.002, r² = 0.284) on superoxide dismutase activity was confi rmed. There was no effect of sex on any of the antioxidant parameters measured. However, we observed a tendency of the effect of sex (p = 0.063, r² = 0.118), as well as age (p = 0.073, r² = 0.111), on the activity of glutathione peroxidase. Our results are in part comparable with the results of other studies in which the same types of methods and samples were used to determine antioxidant parameters. In conclusion, the sex and age of dogs should be taken into consideration when planning a study on antioxidant status parameters.

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Section: Discussionmentioning

confidence: 98%

Plasma Total Antioxidant Capacity and Activities of Blood Glutathione Peroxidase and Superoxide Dismutase Determined in Healthy Dogs by Using Commercially Available Kits

et al. 2016

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“…Additional support for this notion is provided by observations showing that MPTP and NOS2 induction synergistically promote degeneration of dopaminergic neurons in culture (47). Thus, S-nitrosylation and inactivation of parkin by NO may contribute to pathogenesis of Parkinson's disease by preventing the degradation of parkin substrates, which accumulation triggers neurodegeneration (48,49).…”

Section: S-nitrosylation Inmentioning

confidence: 77%

Nitric oxide – mediated signalization and nitrosative stress in neuropathology / Azot oksid – posredovana signalizacija i nitrozativni stres u neuropatologiji

Stojanović¹,

Ljubisavljević²,

Stevanović³

et al. 2012

Journal of Medical Biochemistry

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Summary: Nitric oxide (NO) is an important signalling molecule in a variety of physiological processes. NO, a gas, is produced from L-arginine by different isoforms of the nitric oxide synthase and serves as mediator in important physiological functions, such as promoting vasodilation of blood vessels and mediating communication between nervous system cells. Contradictory to its physiologic actions, free radical activity of NO can cause cellular damage by the induction of nitrosative stress with significant implications on nervous system diseases. Although the mechanism of NOmediated neurodegeneration still remains unclear, numerous studies suggest its crucial role in modification of protein functions by nitrosylation and nitro-tyrosination. NO contributes to glutamate excitotoxicity, participates in organelle fragmentation, inhibits mitochondrial respiratory complexes and mobilizes zinc from the internal stores. Recently, NO has been emerged as a mediator of epigenetic gene expression and chromatin changes. Besides, NO is a key mediator in the regulation of inflammatory and immune response of the central nervous system. It is involved in down regulation of several aspects of CNS inflammation, but also has a dual role in that it is required for inflammation in some situations. Keywords: nitric oxide, nitrosative stress, protein S-nitrosylation, neuroinflammation, neurodegenerationKratak sadr`aj: Azot monoksid je va`an signalni molekul u brojnim fiziolo{kim procesima. Ovaj gas se stvara iz L-arginina dejstvom tri izoforme azot monoksid sintaze i medijator je va`nih fiziolo{kih funkcija, kao {to su posredovanje u regulaciji tonusa krvnih sudova i komunikaciji }elija nervnog sistema. Nasuprot ovim ulogama, kao slobodni radikal, NO mo`e izazvati }elijsko o{te}enje indukcijom nitrozativnog stresa, {to ima zna~ajne implikacije u bolestima nervnog sistema. Mada je mehanizam neurodegeneracije posredovane azot monoksidom jo{ uvek nerazja{njen, brojne studije ukazu ju na njegovu klju~nu ulogu u modifikaciji funkcije proteina kroz procese S-nitrozilacije i nitrovanja tirozina. On doprinosi glutamatnoj ekscitotoksi~nosti, u~estvuje u fragmentaciji organela, inhibi{e mitohondrijalne respiratorne komplekse i mobili{e cink iz unutra{njih depoa. Nedavno je ukazano da mo`e biti medijator epigenetske genske ekspresije i promena hromatina. Pored toga, NO je klju~ni posrednik u regulaciji inflamatornog i imunog odgovora CNS. On u~estvuje u nishodnoj regulaciji nekoliko aspekata inflamacije CNS, ali tako|e ispoljava dualisti~ke efekte u uslovima inflamacije.

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“…Increased iron content in circulation and tissues contributes to the generation of free radicals through the Fenton reaction. Under such conditions, it is likely that Cp ferroxidase activity upregulates to handle the increased availability of ferrous iron, thus enhancing the efflux of ferric iron from stores and accelerating its uptake by transferrin in the circulation (23,24,37).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Haptoglobin Polymorphism and Oxidative Stress in Hemodialysis Patients

Hamad¹,

Awadallah²,

Nasr³

2013

Journal of Medical Biochemistry

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Summary Background: The relationship between haptoglobin polymorphism and oxidative stress in hemodialysis patients is not fully understood. In this study, total antioxidant capacity and ce ru - loplasmin ferroxidase activity were evaluated in relation to haptoglobin phenotype distribution in hemodialysis patients. Methods: Serum samples collected from 161 patients and 84 healthy controls were haptoglobin-typed by electrophoresis. Ceruloplasmin ferroxidase activity and total antioxidant capacity were assayed using colorimetric methods. Results: Irrespective of the haptoglobin phenotype, patients exhibited significantly lower total antioxidant capacity (1.42± 0.29 vs. 1.55±0.28 mmol/L, P=0.002) and higher ferroxidase activity than controls. Frequency of Hp1-1 and Hp2-1 in patients was 15.5% and 36% as compared with 9.5% and 41.7% in controls. While ferroxidase activity was lower in Hp2-2 patients than in controls (142±61 vs. 179±47 U/L, P=0.002), it was higher in Hp2-1 (173±56 U/L) and Hp1-1 (170±54 U/L) patients than in controls (141±43 and 99±30 U/L respectively) (P=0.002 and 0.009). Ferroxidase activity in Hp2-2 patients was significantly lower than that of Hp2-1 or Hp1-1 patients (P=0.004 and 0.034). Total antioxidant capacity was significantly lower only in Hp2-2 patients (1.44±0.25) compared to that in Hp2-2 controls (1.65±0.22) (P=0.000). Conclusions:These findings suggest that haptoglobin polymorphism can differentially impact oxidative stress levels in hemodialysis patients.

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Age-Related Blood Antioxidant Capacity in Men and Women

Cited by 14 publications

References 28 publications

Plasma Total Antioxidant Capacity and Activities of Blood Glutathione Peroxidase and Superoxide Dismutase Determined in Healthy Dogs by Using Commercially Available Kits

Plasma Total Antioxidant Capacity and Activities of Blood Glutathione Peroxidase and Superoxide Dismutase Determined in Healthy Dogs by Using Commercially Available Kits

Nitric oxide – mediated signalization and nitrosative stress in neuropathology / Azot oksid – posredovana signalizacija i nitrozativni stres u neuropatologiji

The Relationship between Haptoglobin Polymorphism and Oxidative Stress in Hemodialysis Patients

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