Age versus nutritional state in the development of central leptin resistance

Pétervári, Erika; Rostás, Ildikó; Soós, Szilvia; Tenk, Judit; Mikó, Alexandra; Füredi, Nóra; Székely, Miklós; Balaskó, Márta

doi:10.1016/j.peptides.2014.03.011

Cited by 27 publications

(21 citation statements)

References 40 publications

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“…In any event, being overweight did not reduce the central sensitivity to leptin in peripubertal female rats, at least in regard to STAT3 activation, as was reported to occur in adult rats (46). Indeed, at this time point, the STAT3 response to leptin was greater in overweight rats, which could be related to their reduced levels of PTP1B.…”

Section: Discussionsupporting

confidence: 44%

Increased Prepubertal Body Weight Enhances Leptin Sensitivity in Proopiomelanocortin and Neuropeptide Y Neurons Before Puberty Onset in Female Rats

et al. 2015

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Pubertal onset may be advanced by obesity, with leptin potentially acting as a permissive factor. We hypothesized that having increased body weight (BW) prepubertally affects the ability of leptin to activate intracellular signaling pathways and modulate the expression of hypothalamic neuropeptides involved in reproduction and metabolism. Because being raised in small litters (SLs) tends to increase BW at weaning, female rats were raised in litters of 4 or large litters (LLs) of 12 pups. Leptin (3 μg/g BW) or vehicle (saline) was injected sc at postnatal day (PND) 21 and 30. Rats raised in SLs weighed more at both ages, but relative visceral and subcutaneous fat was increased only on PND21. Serum leptin levels were not different at PND21 or PND30. At PND21, key elements of intracellular leptin signaling (phosphorylated signal transducer and activator of transcription 3 and phosphorylated Akt [p-Akt]) were lower in SL than in LL rats. Leptin injection stimulated phosphorylated signal transducer and activator of transcription 3 in both groups, with a greater increase in LL, whereas p-Akt rose only in SL rats. At PND30, basal leptin signaling did not differ between LL and SL rats. Leptin activation of Akt was similar at 45 minutes, but at 2 hours p-AKT levels were higher in SL than in LL rats, as was the decrease in neuropeptide Y mRNA and increase in pro-opiomelanocortin mRNA levels. No change in the reproductive axis was found. Thus, being raised in SLs increases BW and visceral body fat content, fails to increase plasma leptin concentrations, and increases the leptin responsiveness of both neuropeptide Y and pro-opiomelanocortin cells in the prepubertal hypothalamus.

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Section: Discussionsupporting

confidence: 44%

Increased Prepubertal Body Weight Enhances Leptin Sensitivity in Proopiomelanocortin and Neuropeptide Y Neurons Before Puberty Onset in Female Rats

et al. 2015

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“…The ICV infusion technique used in the chronic study did not allow collection of convincing data on the 1st day of infusion due to the simultaneously appearing acute effects of the surgical intervention, i.e. implantation of the ICV cannula of the Brain Kit and that of the Alzet osmotic minipump (Pétervári et al, 2011(Pétervári et al, , 2014. Thus, our present results may indicate that the onset of the hyperthemic response in the middle-aged group (seen in chronic experiments) is delayed.…”

Section: Discussionmentioning

confidence: 73%

Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Rostás

Füredi

Tenk

et al. 2015

Journal of Thermal Biology

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“…Scarpace et al (2000) has shown that 7 days of subcutaneous leptin administration increased its serum levels and diminished food intake with greater significance for young rats (Scarpace et al 2000a), leading to the conclusion that older individuals are resistant to the effects of leptin (Scarpace et al 2000a). Conversely, recent work demonstrated that in old non-obese and calorierestricted rats, 7 days of intra-cerebroventricular leptin infusion efficiently decreased food intake (Petervari et al 2014). Petervari et al (2014) suggested that ageing per se does not promote leptin resistance development; rather, early appearance of obesity leads to the progressive loss of the hypermetabolic effects of leptin (Petervari et al 2014).…”

Section: Leptinmentioning

confidence: 99%

“…Conversely, recent work demonstrated that in old non-obese and calorierestricted rats, 7 days of intra-cerebroventricular leptin infusion efficiently decreased food intake (Petervari et al 2014). Petervari et al (2014) suggested that ageing per se does not promote leptin resistance development; rather, early appearance of obesity leads to the progressive loss of the hypermetabolic effects of leptin (Petervari et al 2014).…”

Section: Leptinmentioning

confidence: 99%

“…As mentioned, studies on rodents demonstrated that aged individuals show reduced responsiveness to externally derived leptin (Scarpace et al 2000a;Scarpace et al 2000b). Thus, it has been proposed that leptin signaling might be impaired due to an age-related elevation in obesity and serum leptin levels (Scarpace and Tumer 2001;Petervari et al 2014;Scarpace et al 2000b). Maintaining stable AT mass and its function seems to be crucial for physiological homeostasis during the ageing process, which may involve regular leptin signaling (Carter et al 2013).…”

Section: Leptinmentioning

confidence: 99%

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Obesity and related consequences to ageing

Jura

Kozak

2016

AGE

346

203

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Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.

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Age versus nutritional state in the development of central leptin resistance

Cited by 27 publications

References 40 publications

Increased Prepubertal Body Weight Enhances Leptin Sensitivity in Proopiomelanocortin and Neuropeptide Y Neurons Before Puberty Onset in Female Rats

Increased Prepubertal Body Weight Enhances Leptin Sensitivity in Proopiomelanocortin and Neuropeptide Y Neurons Before Puberty Onset in Female Rats

Age-related alterations in the central thermoregulatory responsiveness to alpha-MSH

Obesity and related consequences to ageing

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