AKTIVITAS IMUNOMODULATOR FRAKSI ETIL ASETAT DAUN SOM JAWA (Talinum paniculatum (Jacq.) Gaertn) TERHADAP RESPON IMUN SPESIFIK

Puspitaningrum, Ika; Franyoto, Yuvianti Dwi; Munisih, Siti

doi:10.31942/jiffk.v15i2.2566

Cited by 8 publications

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“…The increase in immune cells correlates with an increase in spleen weight as (Figure 4). The increase in the index of the spleen organ indicates an effect as an immunostimulant activity (Puspitaningrum, et al, 2017). Especially at a dose of 52 mg/kg bw there was a significant increase in spleen organ index compared to controls (p<0.05).…”

Section: Resultsmentioning

confidence: 89%

“…IL-2 and IFN-ɣ are also typical cytokines in activating helper T cells (Th1) and these two cytokines exhibit antiviral, immunomodulatory (immunoregulatory) and antitumor properties. IFN-ɣ can activate resting macrophages to become active macrophages (Macrophage Activating Cytokine) and cellular immune responses (Nurkhasanah and Novitasari, 2019;Puspitaningrum, et al, 2017;Shin, et al, 2016). This enhanced effect of IL-2 has special relevance for its prophylactic and therapeutic potential in enhancing the immune response to various infectious diseases (infectious microorganisms) and antitumor with few side effects (Kumar, et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

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Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverwort Ethanol Extract in BALB/c Mice

Purkon

2021

Indonesian J Pharm

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Immunostimulants are compounds that can stimulate an immune response by increasing the activity of non-specific and specific components of the immune system (humoral and cellular) against certain infections and diseases. The liverwort plant species Marchantia paleacea Bertol. has long been used as a source of nutrition and empirical medicine. However, scientifically there is still not much research data on immunomodulators in these plants. This study aims to determine the activity of immunomodulators in the ethanol extract of the herb Marchantia paleacea Bertol. in male mice of BALB/c strain. Bioactive compounds from this plant were extracted by maceration method using 96% ethanol. Extract characterization and phytochemical screening were determined according to WHO guidelines and standard procedures from previous studies. The immunomodulatory activity of the extract was tested by carbon clearance method and lymphoid organ index (non-specific responses), primary and secondary antibody titer tests (humoral specific responses), IL-2 cytokine levels and IFN-ɣ from serum secondary antibodies and delayed-type hypersensitivity reaction/DTH (cellular specific response). The results of qualitative phytochemical screening contained flavonoid compounds, saponins, phenolics, tannins and steroids/triterpenoids. The results of the non-specific immune response immunomodulator test showed that the dose of 52 mg/kg bw had the largest phagocytic index of 1.52 which included strong immunostimulation (K > 1.5) and the organ spleen index of 0.55 ± 0.11 which increased significantly compared to the control (p<0.05). The data on the acquisition of specific immune responses in the primary and secondary antibody titer test in the three test extracts resulted in increased titer levels compared to the control and at a dose of 52 mg/kg bw could significantly increase the levels of IL-2 cytokines in the control group (p<0,05). Meanwhile, in the DTH test, doses of 13 and 26 mg/kg bw could significantly increase the thickness of the soles of mice compared to controls (p<0.05).

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverwort Ethanol Extract in BALB/c Mice

Purkon

2021

Indonesian J Pharm

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“…Sistem imun merupakan serangkaian mekanisme dalam tubuh yang bertugas merespon ancaman dari luar tubuh seseorang. Saat terjadi serangan oleh zat asing, maka sistem imun akan distimulasi oleh antigen sehingga menimbulkan dua respon yaitu respon imun spesifik (acquired immunity) dan respon imun nonspesifik (innate immunity) (Puspitaningrum et al 2018). Kerja sistem imun yang tidak terkontrol dapat menyebabkan kelainan imun yang dibagi dalam tiga klasifikasi diantaranya imunodefisensi, intraseluler, dan ekstraseluler.…”

Section: Pendahuluanunclassified

“…Imunomodulator alami dapat diperoleh dari tanaman. Senyawa bioaktif dalam tanaman dapat meningkatkan aktifitas sistem imun (Puspitaningrum et al 2018).…”

Section: Pendahuluanunclassified

Kajian Morfologi, Fitokimia, dan Aktivitas Imunomodulator Tiga Spesies Genus Etlingera : E. elatior, E. hemisphaerica, dan E. pauciflora

Vania

Wulan

Saripah

2022

JECP

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Salah satu tanaman khas Indonesia yang berpotensi sebagai imunomodulator adalah genus Etlingera. Indonesia memiliki tiga spesies genus Etlingera yaitu E. elatior, E. hemisphaerica, dan E. pauciflora. Tujuan dari penelitian ini adalah untuk mengkaji informasi terhadap penelitian yang sudah ada sebelumnya mengenai morfologi, kandungan kimia, dan aktivitas imunomodulator tiga spesies genus Etlingera (E. elatior, E. hemisphaerica, dan E. pauciflora). Penelitian ini merupakan penelitian kualitatif dengan metode kajian literatur sistematis. Hasil penelitian menunjukkan bahwa morfologi tiga spesies genus Etlingera dapat dibedakan dari bentuk setiap bagian tanamannya. Bunga E. elatior memiliki tepian berwarna putih dengan bentuk mahkota meruncing, sedangkan E. hemisphaerica memiliki tepian bunga berwarna kuning terang dengan bentuk mahkota bunga melebar. E. pauciflora memiliki bunga berwarna merah kejinggan dengan bentuk runcing memanjang. Tanaman ini mengandung berbagai senyawa yang dapat meningkatkan imunitas tubuh seperti flavonoid, tanin, terpenoid, saponin dan essential oil. Etlingera elatior menunjukkan aktivitas paling tinggi sebagai imunostimulan dengan mekanisme kerja fagositosis, sedangkan spesies Etlingera hemisphaerica juga memiliki aktivitas dengan mekanisme peningkatan jumlah leukosit yang signifikan namun tetap dalam batas normal sehingga dapat meningkatkan kekebalan tubuh. Belum ditemukan penelitian lebih lanjut terhadap spesies E. pauciflora mengenai kandungan kimia maupun aktivitas imunomodulatornya. Dapat disimpulkan bahwa tanaman genus Etlingera dapat dibedakan secara morfologi, sedangkan dua dari tiga spesies yaitu E.elatior dan E.hemisphaerica memiliki aktivitas sebagai imunostimulan dengan kandungan utamanya adalah flavonoid.One of the typical Indonesian plants that have the potential as an immunomodulator is the genus Etlingera. Indonesia has three species of the genus Etlingera, namely E. elatior, E. hemisphaerica , and E. pauciflora . The purpose of this study was to review information on previous studies regarding the morphology, chemical composition, and immunomodulatory activity of three species of the genus Etlingera ( E. elatior, E. hemisphaerica , and E. pauciflora ). This research is a qualitative research with a systematic literature review method. The results showed that the morphology of the three species of the genus Etlingera could be distinguished from the shape of each part of the plant. E. elatior flowers have white edges with a tapered crown, while E. hemisphaerica flowers have bright yellow edges with wide flower crowns. E. pauciflora has orange-red flowers with an elongated pointed shape. This plant contains various compounds that can increase the body's immunity such as flavonoids, tannins, terpenoids, saponins and essential oils . Etlingera elatior showed the highest activity as an immunostimulant with a phagocytosis mechanism, while Etlingera hemisphaerica species also had activity with a significant increase in leukocyte count but remained within normal limits so as to increase immunity. No further research has been found on E. pauciflora species regarding its chemical content and immunomodulatory activity. It can be concluded that the plants of the Etlingera genus can be distinguished morphologically, while two of the three species, namely E. elatior and E. hemisphaerica have activity as immunostimulants with the main content being flavonoids

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“…Penyakit autoimun dapat diobati dengan golongan obat yang berfungsi menekan respon imun yaitu imunosupresan (2) . Selain menggunakan obat konvensional, kecenderungan gaya hidup masyarakat untuk kembali ke alam (back to nature) menyebabkan penggunaan obat bahan alam juga terus meningkat.…”

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Efek Ekstrak Petroleum Eter Daun Ara (Ficus Racemosa Linn.) pada Indeks Fagositosis Mencit (Mus musculus)

Hamdin¹,

Trihastuty²,

Aini³

2019

jifi

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Terpenoid compound from ara's leaf is known to have immunosuppressant activity by inhibit blood cells proliferation. Immunosuppressant is a group of drugs that can suppress excessive immune responses. The aim of this research was investigated the immunosuppressant eff ect of petroleum ether from ara's leaf (Ficus racemosa Linn.) on mice (Mus musculus). The immunosuppressant activity was conducted by carbon clearance method to investigate the ability of phagocytosis with carbon as an antigen that is injected intravenously, followed by determining organ index. All data was analyzed by SPSS. The result showed that at dose of 560 mg/kgbw and 1120 mg/kgbw, extract found to have immunostimulant activity with phagocytic index values respectively of 1.5 and 1.1, while the dose of 1680 mg/kgbw was immunosuppressant with phagocytic index 0.7. The lymphoid organ index showed a signifi cantly diff erence between petroleum ether from ara leaf extract by dose 1680 mg/kgbw with negative control (p<0.05). Based on the results of the non-specifi c immune response, it can be concluded that the petroleum ether ara's leaf extract by dose 1680 mg/kgbw has immunosuppressant activity.Abstrak: Senyawa terpenoid daun ara diketahui memiliki aktivitas imunosupresan dengan menghambat proliferasi sel darah. Imunosupresan merupakan golongan obat yang dapat menekan respon imun berlebihan. Penelitian ini bertujuan untuk mengetahui aktivitas imunosupresan ekstrak petroleum eter daun ara (Ficus racemosa. Linn) terhadap mencit (Muss musculus). Uji imunosupresan dilakukan dengan metode bersihan karbon untuk mengetahui kemampuan fagositosis dengan karbon sebagai antigen yang diinjeksikan intravena, dilanjutkan dengan menghitung indeks organ. Seluruh data yang diperoleh kemudian dianalisis statistik menggunakan SPSS. Hasil uji bersihan karbon menunjukkan bahwa ekstrak petroleum eter daun ara dosis 560 mg/kgBB bersifat imunostimulan sedang dosis 1120 mg/kgBB bersifat imunostimulan lemah dengan nilai indeks fagositosis berturut-turut 1,5 dan 1,1; sedangkan dosis 1680 mg/kgBB bersifat imunosupresan dengan indeks fagositosis 0,7. Hasil uji indeks organ limfoid menunjukkan perbedaan signifi kan antara ekstrak petroleum eter dosis 1680 mg/kgBB dengan kontrol negatif (p<0,05). Berdasarkan hasil uji respon imun non spesifi k disimpulkan bahwa ekstrak petroleum eter daun ara dosis 1680 mg/kgBB mempunyai aktivitas imunosupresan.Kata kunci: Imunosupresan, Ficus racemosa Linn., fagositosis, bersihan karbon.

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AKTIVITAS IMUNOMODULATOR FRAKSI ETIL ASETAT DAUN SOM JAWA (Talinum paniculatum (Jacq.) Gaertn) TERHADAP RESPON IMUN SPESIFIK

Cited by 8 publications

References 0 publications

Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverwort Ethanol Extract in BALB/c Mice

Immunostimulant Activity of Marchantia paleacea Bertol. Herb Liverwort Ethanol Extract in BALB/c Mice

Kajian Morfologi, Fitokimia, dan Aktivitas Imunomodulator Tiga Spesies Genus Etlingera : E. elatior, E. hemisphaerica, dan E. pauciflora

Efek Ekstrak Petroleum Eter Daun Ara (Ficus Racemosa Linn.) pada Indeks Fagositosis Mencit (Mus musculus)

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