2017
DOI: 10.1016/j.snb.2017.01.190
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Aldehyde bearing bis-cyclometalated Ir(III) complex as selective photoluminescence turn-on probe for imaging intracellular homocysteine

Abstract: A new photoluminescence (PL) turn-on probe based on aldehyde bearing bis-cyclometalated Ir(III) complex, [Ir(bt) 2 phen-CHO] + PF 6-(1), is synthesized and applied to imaging homocysteine (Hcy) in living cells. The probe 1 is readily prepared by using 2-phenylbenzothiazole (bt) as main ligand and 1,10-phenanthroline-5-carboxaldehyde (phen-CHO) as ancillary ligand. Probe 1 displayed excellent selective PL enhancement in response to Hcy in neutral buffer solution based on aldehyde group cyclization reaction. The… Show more

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Cited by 24 publications
(14 citation statements)
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“…The formed ring affects the transfer of electrons, thus causing changes in fluorescence intensity and ultraviolet light. The possible sensing mechanism and binding mode of probe DBTC with Hcy are shown in Figure , which was consistent with the reported results. …”
Section: Resultssupporting
confidence: 90%
“…The formed ring affects the transfer of electrons, thus causing changes in fluorescence intensity and ultraviolet light. The possible sensing mechanism and binding mode of probe DBTC with Hcy are shown in Figure , which was consistent with the reported results. …”
Section: Resultssupporting
confidence: 90%
“…In order to explain and confirm the binding mechanism between APTC and Hcy in more depth, the peak at m / z = 466.2134 belongs to the product of [APTC+Hcy], which was evidently observed by mass spectrometry (Figure S8). The plausible binding way of APTC with Hcy was revealed in Figure , which was the same as reported in previous literatures …”
Section: Resultssupporting
confidence: 82%
“…Therefore, it was expected that 2 -PhS – would produce TPrA • more efficiently than 1 -PhS – via a smooth catalytic process. Ir­(III) complexes with a formyl group on the main ligand exhibited weaker PL intensities compared to those without a formyl group. , As expected, 2 -PhS – exhibited much weaker PL intensity than 1 -PhS – . However, the ECL intensity of 2 -PhS – was comparable to that of 1 -PhS – , which could be explained by the smooth catalytic process of 2 -PhS – (Figure S10).…”
Section: Results and Discussionsupporting
confidence: 59%