Aldicarb: A Case Series of Watermelon-Borne Carbamate Toxicity

D'Haenens, Joseph P; McDonald, Kimberly W; Langley, Ricky L.; Higgins, Sheila; Scott, Rick; Farquhar, Patrick N; Meggs, William J.

doi:10.1080/1059924x.2013.766141

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…Carbamates are selective herbicides, insecticides, acaricides, nematicides, molluscicides, or fungicides in fruits and vegetables. The most widespread carbamate pesticide, aldicarb, found in high concentrations in watermelons, caused food poisoning that affected more than 2000 people in the USA in 1985 [ 234 ]. Quaternary ammonium salts (paraquat; diquat; chlormequat) are the most toxic of all insecticides or herbicides.…”

Section: Lactic Acid Bacteria For Reducing Pesticide Levels In Foodmentioning

confidence: 99%

The Complex Role of Lactic Acid Bacteria in Food Detoxification

et al. 2022

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Toxic ingredients in food can lead to serious food-related diseases. Such compounds are bacterial toxins (Shiga-toxin, listeriolysin, Botulinum toxin), mycotoxins (aflatoxin, ochratoxin, zearalenone, fumonisin), pesticides of different classes (organochlorine, organophosphate, synthetic pyrethroids), heavy metals, and natural antinutrients such as phytates, oxalates, and cyanide-generating glycosides. The generally regarded safe (GRAS) status and long history of lactic acid bacteria (LAB) as essential ingredients of fermented foods and probiotics make them a major biological tool against a great variety of food-related toxins. This state-of-the-art review aims to summarize and discuss the data revealing the involvement of LAB in the detoxification of foods from hazardous agents of microbial and chemical nature. It is focused on the specific properties that allow LAB to counteract toxins and destroy them, as well as on the mechanisms of microbial antagonism toward toxigenic producers. Toxins of microbial origin are either adsorbed or degraded, toxic chemicals are hydrolyzed and then used as a carbon source, while heavy metals are bound and accumulated. Based on these comprehensive data, the prospects for developing new combinations of probiotic starters for food detoxification are considered.

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Section: Lactic Acid Bacteria For Reducing Pesticide Levels In Foodmentioning

confidence: 99%

The Complex Role of Lactic Acid Bacteria in Food Detoxification

et al. 2022

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“…Aldicarb is highly toxic and is labeled as a “restricted use pesticide” in the United States. It was responsible for several outbreaks of food poisonings. , Due to its highly toxic effects, a major aldicarb product, Temik, was phased out by the Environmental Protection Agency (EPA) in 2010. However, the EPA approved a new product, AgLogic 15G, which made its debut in Georgia in 2016 and was released in other states in 2017, increasing the risk of aldicarb exposure.…”

Section: Introductionmentioning

confidence: 99%

The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice

Gao

Chi

et al. 2018

Chem. Res. Toxicol.

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The gut microbiome is highly involved in numerous aspects of host physiology, from energy harvest to stress response, and can confer many benefits to the host. The gut microbiome development could be affected by genetic and environmental factors, including pesticides. The carbamate insecticide aldicarb has been extensively used in agriculture, which raises serious public health concerns. However, the impact of aldicarb on the gut microbiome, host metabolome, and lipidome has not been well studied yet. Herein, we use multiomics approaches, including16S rRNA sequencing, shotgun metagenomics sequencing, metabolomics, and lipidomics, to elucidate aldicarb-induced toxicity in the gut microbiome and the host metabolic homeostasis. We demonstrated that aldicarb perturbed the gut microbiome development trajectory, enhanced gut bacterial pathogenicity, altered complex lipid profile, and induced oxidative stress, protein degradation, and DNA damage. The brain metabolism was also disturbed by the aldicarb exposure. These findings may provide a novel understanding of the toxicity of carbamate insecticides.

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