All-Polysaccharide, Self-Healing Injectable Hydrogels Based on Chitosan and Oxidized Hydroxypropyl Polysaccharides

Chen, Junyi; Nichols, Brittany L.B.; Norris, Ann M; Frazier, Charles E.; Edgar, Kevin J.

doi:10.1021/acs.biomac.0c01046

Cited by 55 publications

(34 citation statements)

References 51 publications

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“…There has been a large array of development achieved in polymer hydrogel as a smart biomaterial due to its ability to mimic the native extracellular matrix (ECM), tunable properties, biocompatibility, biodegradability, and support for tissue regeneration. Numerous natural biomacromolecules and synthetic polymers, such as liposome [84,85], peptide [86], nucleic acid [87], and polysaccharide [88], contain self-healing hydrogels and have shown promising applications in cell culture, tissue engineering, drug delivery, and wound dressing. An overview of the type of polymer used based on self-healing hydrogels with various mechanisms, along with their applications in the biomedical field, is shown in Table 4.…”

Section: Self-healing Polymeric Materials and Their Efficiency As Healing Agents In Medical Fieldsmentioning

confidence: 99%

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

et al. 2021

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The versatility of polymeric materials as healing agents to prevent any structure failure and their ability to restore their initial mechanical properties has attracted interest from many researchers. Various applications of the self-healing polymeric materials are explored in this paper. The mechanism of self-healing, which includes the extrinsic and intrinsic approaches for each of the applications, is examined. The extrinsic mechanism involves the introduction of external healing agents such as microcapsules and vascular networks into the system. Meanwhile, the intrinsic mechanism refers to the inherent reversibility of the molecular interaction of the polymer matrix, which is triggered by the external stimuli. Both self-healing mechanisms have shown a significant impact on the cracked properties of the damaged sites. This paper also presents the different types of self-healing polymeric materials applied in various applications, which include electronics, coating, aerospace, medicals, and construction fields. It is expected that this review gives a significantly broader idea of self-healing polymeric materials and their healing mechanisms in various types of applications.

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Section: Self-healing Polymeric Materials and Their Efficiency As Healing Agents In Medical Fieldsmentioning

confidence: 99%

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

et al. 2021

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“…Furthermore, thermo-responsive polymers can be used as injectable biomaterials in the form of a hydrogel, as shown in Figure 6 [205]. This allows the in situ formation of scaffolds, minimizing the employment of invasive methods, and representing a novel and advanced drug delivery system especially for subcutaneous application [206][207][208][209]. Hydrogels possess a 3D structure that can be modified in terms of their physicochemical properties to obtain a firmly attached scaffold to the external and internal wound [210].…”

Section: Drug Delivery Applications Of Bioengineered Thermo-responsive Scaffolds In Wound Healingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…As a result, the polymers applied in injectable hydrogel system should meet such criteria as injectable, nontoxic crosslinking, and biodegradable. [ 136 ]…”

Section: Fabrication Of Polysaccharide‐based Scaffoldsmentioning

confidence: 99%

“…Several polysaccharides, including chitosan, [ 136 ] hyaluronic acid, [ 137 ] alginate, [ 138 ] and dextran have been developed as injectable hydrogels. Fan et al developed pH‐sensitive hydrogels from carboxymethyl chitosan and oxidized chondroitin sulfate, [ 139 ] from which they demonstrated the injectability of the hydrogel with in vitro implantation of bovine articular chondrocytes.…”

Section: Fabrication Of Polysaccharide‐based Scaffoldsmentioning

confidence: 99%

Engineering Polysaccharides for Tissue Repair and Regeneration

et al. 2021

Macromolecular Bioscience

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The success of repair or regeneration depends greatly on the architecture of 3D scaffolds that finely mimic natural extracellular matrix to support cell growth and assembly. Polysaccharides have excellent biocompatibility with intrinsic biological cues and they have been extensively investigated as scaffolds for tissue engineering and regenerative medicine (TERM). The physical and biochemical structures of natural polysaccharides, however, can barely meet all the requirements of tissue‐engineered scaffolds. To take advantage of their inherent properties, many innovative approaches including chemical, physical, or joint modifications have been employed to improve their properties. Recent advancement in molecular and material building technology facilitates the fabrication of advanced 3D structures with desirable properties. This review focuses on the latest progress of polysaccharide‐based scaffolds for TERM, especially those that construct advanced architectures for tissue regeneration.

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All-Polysaccharide, Self-Healing Injectable Hydrogels Based on Chitosan and Oxidized Hydroxypropyl Polysaccharides

Cited by 55 publications

References 51 publications

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Engineering Polysaccharides for Tissue Repair and Regeneration

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