Allylamine Type Xanthone Antimycotics

Salmoiraghi, Isabella; Rossi, Maddalena; Re, P. Da

doi:10.1002/(sici)1521-4184(199806)331:6<225::aid-ardp225>3.3.co;2-x

Cited by 4 publications

(5 citation statements)

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“…Cudrania fruticosa yielded an isoprenylated xanthone, cudrafrutixanthone which showed antifungal activity against C. albicans [55]. Xanthone analogues bearing the basic chain of butenafine were reported for significant activity against C. neoformans (1.5 mg/ml) [56].…”

Section: Xanthonesmentioning

confidence: 99%

Natural products – antifungal agents derived from plants

Arif

Bhosale

Kumar

et al. 2009

Journal of Asian Natural Products Research

320

181

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A new spectrum of human fungal infections is increasing due to increased cancer, AIDS, and immunocompromised patients. The increased use of antifungal agents also resulted in the development of resistance to the present drugs. It makes necessary to discover new classes of antifungal compounds to cure fungal infections. Plants are rich source of bioactive secondary metabolites of wide variety such as tannins, terpenoids, saponins, alkaloids, flavonoids, and other compounds, reported to have in vitro antifungal properties. Since the plant kingdom provides a useful source of lead compounds of novel structure, a wide-scale investigation of species from the tropics has been considered. Therefore, the research on natural products and compounds derived from natural products has accelerated in recent years due to their importance in drug discovery. A series of molecules with antifungal activity against different strains of fungus have been found in plants, which are of great importance to humans. These molecules may be used directly or considered as a precursor for developing better molecules. This review attempts to summarize the current status of important antifungal compounds from plants.

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Section: Xanthonesmentioning

confidence: 99%

Natural products – antifungal agents derived from plants

Arif

Bhosale

Kumar

et al. 2009

Journal of Asian Natural Products Research

320

181

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“…To this end, the structure-activity relationship (SAR) studies are currently available for the following activities: tuberculostatic [16,[85][86][87], antimycotic [88], antimalarial [89,90], antiplatelet [91][92][93][94], antithrombotic [95], antiinflammatory [54,96,97], antiallergic [13,22,24], antitumor [7,17,81,[98][99][100][101][102][103][104][105][106][107], antimutagenic [108][109][110], and antioxidant [38,43,55]. Furthermore, SAR studies have been also developed in the field of adrenergic blocking agents [7,11] [112], leukotriene (LT) B4 receptors blocking agents [113][114][115], as well as for effects on several enzymes, such as acetylcholinesterase [116,117], aldose reductase [118], aromatase …”

Section: Biological Activitiesmentioning

confidence: 99%

Xanthone Derivatives: New Insights in Biological Activities

Pinto¹,

Sousa

Nascimento

2005

CMC

450

232

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Xanthones or xanthen-9H-ones (dibenzo-gamma-pirone) comprise an important class of oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological activities of this class of compounds are associated with their tricyclic scaffold but vary depending on the nature and/or position of the different substituents. In this review, an array of biological/pharmacological effects is presented for both natural and synthetic xanthone derivatives, with an emphasis on some significant studies on structure-activity relationships. The antitumor activity of some xanthones as well as the related targets, particularly PKC modulation studies, is also discussed in detail. Examples of the "hit" compounds involved in cancer therapy, namely DMXAA, psorospermin, mangiferin, norathyriol, mangostins, and AH6809, a prostanoid receptor antagonist, are also mentioned. Finally, a historical perspective of these xanthonic derivatives, their relevance as therapeutic agents and/or their uses as pharmacological tools and as extract components in folk medicine are also highlighted.

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“…Interestingly, with the exception of compounds 5 and 10, some selectivity toward dermatophyte filamentous fungi was observed, with compounds 3,4, 6,11,12,16,19,23,[25][26][27] showing no activity against Candida species, C. neoformans, or A. fumigatus even at the maximum concentrations tested (250 lg mL )1 ). In contrast, compounds 5 and 10 were active in the same range of concentrations as fluconazole to C. neoformans and were found to inhibit the growth of A. fumigatus (MIC = 62.5 and 31.3 lg mL )1 , respectively), which displays the lowest susceptibility to fluconazole (MIC > 128 lg mL )1 ).…”

Section: Discussionmentioning

confidence: 97%

“…Concerning antifungal activity, investigations have been undertaken in the group of both synthetic (8,9) and naturally occurring xanthone derivatives. Consequently, in an attempt to search for naturally occurring antifungal compounds, a number of xanthones with clinical value against fungal infections, from higher plants (8,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) and microorganisms (27)(28)(29)(30)(31)(32)(33)(34) including marine species (35,36), have been identified. These xanthones are mainly divided into four subclasses: simple oxygenated (8,15,17,25,26,35,36), prenylated (8,(10)(11)(12)(13)(14)(16)(17)(18)(19)…”

mentioning

confidence: 99%

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

Pinto

Afonso

Duarte

et al. 2011

Chemical Biology &Amp; Drug Design

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The increasing resistance of pathogenic fungi to antifungal compounds and the reduced number of available drugs led to the search for therapeutic alternatives among natural products, including xanthones. The antifungal activity of 27 simple oxygenated xanthones was evaluated by determination of their minimal inhibitory concentration on clinical and type strains of Candida, Cryptococcus, Aspergillus and dermatophytes, and their preponderance on the dermatophytic filamentous fungi was observed. Furthermore, a simple and efficient HPLC method with UV detection to study the effect of the active xanthones on the biosynthesis of ergosterol was developed and validated. Using this methodology, the identification and quantification of fungal sterols in whole cells of Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and Trichophyton mentagrophytes were accomplished. In summary, 1,2-dihydroxyxanthone was found to be the most active compound against all strains tested, showing its effect on sterol biosynthesis by reducing the amount of ergosterol detected.

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Allylamine Type Xanthone Antimycotics

Cited by 4 publications

References 0 publications

Natural products – antifungal agents derived from plants

Natural products – antifungal agents derived from plants

Xanthone Derivatives: New Insights in Biological Activities

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

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