.ALPHA.-Glucosidase Inhibitors Ellagic Acid Derivatives with Immunoinhibitory Properties from Terminalia superba

Tabopda, Turibio Kuiate; Ngoupayo, Joseph; Liu, Jiawei; Ali, Muhammad; Khan, Shafqat Ullah; Ngadjui, Bonaventure T.; Luu, Bang

doi:10.1248/cpb.56.847

Cited by 31 publications

(15 citation statements)

References 15 publications

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“…Although ellagic acid has already been isolated from the Sapindaceae family [4], this is the first report of its derivatives in this family. Despite the moderate antibacterial potency of compounds 1 and 2, several ellagic acid derivatives isolated from plants exhibit antiplasmodial, cytotoxic, antioxidant, and α-glucosidase inhibitory activities [4,20,23,24]. All these results highlight the potency of this class of secondary metabolites and suggest potential uses of plants from the genus Pancovia in medicine.…”

Section: Resultsmentioning

confidence: 99%

“…Its 1 H NMR spectrum (Table 1) showed also four aromatic protons as singlets at δ = 7.90 (s, H-5), 7.63 (s, H-5 ), and 7.04 (s, H-2 /H-6 ) and three methoxy groups (δ = 4.01, 4.06 and 4.10). The 28 carbon signals observed in the 13 C NMR of compound 1 include, besides glucopyranosyl and methoxy carbons, those for the two 7-carbon units of an ellagic acid skeleton and those for another highly oxygenated phenyl ring attributed to a gallic acid moiety with the carbonyl group at δ = 165.9 [20]. The ellagic acid moiety was confirmed by its HMBC correlations, in particular those from H-5 (δ = 7.90) to C-3, C-4, C-6 and C-7 and from H-5 (δ = 7.63) to C-3 , C-4 , C-6 and C-7 .…”

Section: Resultsmentioning

confidence: 99%

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Antibacterial Ellagic Acid Derivatives and Other Constituents from Pancovia pedicellaris

Soh

Bankeu

Lenta

et al. 2009

Zeitschrift Für Naturforschung B

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Two new ellagic acid derivatives, named panconosides A (1) and B (2) were isolated from Pancovia pedicellaris together with eleven known compounds (3 -13). The structures of 1 and 2, as well as those of the known compounds were established by spectroscopic methods and by comparison with previously reported data. Compounds 1 and 2 were tested in vitro for their antibacterial potential against six strains of microorganisms: Micrococcus luteus, Streptococcus ferus, Streptococcus minor, Escherichia coli, Bacillus subtilis, and Pseudomonas agarici. They were found to exhibit moderate antibacterial activity against all the tested strains compared to standard drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antibacterial Ellagic Acid Derivatives and Other Constituents from Pancovia pedicellaris

Soh

Bankeu

Lenta

et al. 2009

Zeitschrift Für Naturforschung B

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“…In our continued work on a-glucosidase inhibitors from plant origin, we surveyed a number of plants from Cameroon and reported a-glucosidase inhibitors from Terminalia superba, 18) Piper umbellatum 19) and Garcinia brevipedicellata. 6) Here we report the isolation and identification of new a-glucosidase inhibitors compounds, brevipsidones A-D (1-4) from leaves of G. brevipedicellata (Clusiaceae).…”

mentioning

confidence: 99%

.ALPHA.-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)

Ngoupayo

Tabopda

Ali

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…These A and B compounds were identified as other active principles of plants from the genus Terminalia by the present study. A number of ellagic acid derivatives close to A and B were also isolated from the stem bark of T. superba by some authors (Kamtchouing et al, 2006 ;Tabopda et al, 2008 ;Kuete et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Antifungal activity of Terminalia superba (combretaceae)

Mathieu¹,

Siaka²,

Marcel³

et al. 2015

JEBAS

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KEYWORDS Terminalia superb Anticandidosic Ellagic acid derivative ABSTRACTThe aim of the present study was to optimize the anticandidosic activities of Terminalia superba (TEKAM4) and the identification of major compounds present in the most active chromatographic fraction. The hydroethanolic extract TEKAM4-X0 was prepared by homogenization employing a blender. Two derivatives extracts of TEKAM4-X0 (X1-1 and X1-2) were obtained by a liquid/liquid partition of TEKAM4-X0 in a mixture of hexane and water (v/v). Three chromatographic fractions (F1, F2 and F3) from X1-2 were separated by means of Sephadex-LH20 gel filtration chromatography. All the extracts were incorporated to Sabouraud according to the agar slanted double dilution method. Ketoconazole was used as standards for antifungal assay. The entire fractions were tested on the previously prepared medium culture containing 1000 cells of C. albicans. Antifungal activity was determined by evaluating antifungal parameters values (MFC and IC50). Lastly, the structures of 2 isolated compounds were elucidated by combination of Flash chromatography and spectroscopic methods, including MS, and multiple stage RMN experiments.

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.ALPHA.-Glucosidase Inhibitors Ellagic Acid Derivatives with Immunoinhibitory Properties from Terminalia superba

Cited by 31 publications

References 15 publications

Antibacterial Ellagic Acid Derivatives and Other Constituents from Pancovia pedicellaris

Antibacterial Ellagic Acid Derivatives and Other Constituents from Pancovia pedicellaris

.ALPHA.-Glucosidase Inhibitors from Garcinia brevipedicellata (Clusiaceae)

Antifungal activity of Terminalia superba (combretaceae)

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