2018
DOI: 10.1515/jomb-2017-0049
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Alterations in Arginase-No-Synthase System of Spermatozoa in Human Subjects with Different Fertility Potential

Abstract: SummaryBackgroundInfertility is an important worldwide problem which affects 10–15% of couples globally. Altered NO production has also been implicated in the pathogenesis of the male infertility. The present study was designed to evaluate the changes in the activity of NO-synthase (NOS) and arginase in spermatozoa of patients with infertility.MethodsThe total NOS, Ca2+-dependent constitutive (cNOS) and Ca2+-independent inducible (iNOS) activity and arginase activity were assessed in sperm cells of patients wi… Show more

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Cited by 16 publications
(18 citation statements)
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“…Under semen abnormalities, the redistribution of activities in NOS system with their shift towards the Ca 2+ independent iNOS was revealed. This indicates dysmetabolic changes in NO biosynthesis, namely its hyperproduction [2]. According to the results of factor analysis, none of indices of this system form a cluster with other biochemical indices in the pathozoospermic samples.…”
Section: Resultsmentioning
confidence: 93%
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“…Under semen abnormalities, the redistribution of activities in NOS system with their shift towards the Ca 2+ independent iNOS was revealed. This indicates dysmetabolic changes in NO biosynthesis, namely its hyperproduction [2]. According to the results of factor analysis, none of indices of this system form a cluster with other biochemical indices in the pathozoospermic samples.…”
Section: Resultsmentioning
confidence: 93%
“…Our former [2][3][4]9] indicate a direction of changes in the biochemical parameters in sperm cells of the infertile men with various forms of semen abnormalities, although it is often a question of combining these forms according to certain criteria. It is known that cluster analysis allows grouping different studied groups at the same values of indices.…”
Section: Resultsmentioning
confidence: 96%
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“…Nitric oxide synthase (NOS) activity assay in the lung tissue supernatant was performed by monitoring the rate of conversion of L-arginine into citrulline [15]. Total protein was measured with Lowry assay [16].…”
Section: Methodsmentioning
confidence: 99%