Amelioration of Intestinal Ischemia–Reperfusion Injury with Intraluminal Hyperoxygenated Solution: Studies on Structural and Functional Changes of Enterocyte Mitochondria1

Gao, Changjun; Xu, Li; Chai, Weidong; Sun, Xude; Zhang, Hui; Zhang, Guihe

doi:10.1016/j.jss.2005.06.022

Cited by 27 publications

(32 citation statements)

References 32 publications

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“…In animal experiments, administration of HOS has been proven to improve function and integrity of organs after injury to the myocardium, spinal cord and brain [6,7,9,10] . Clinical application of HOS has been used successfully in the treatment of burn shock and hypovolemic shock [24] .…”

Section: Discussionmentioning

confidence: 99%

“…The method of preparing HOS has been described previously [6] . Briefly, 500 ml 0.9% sodium chloride solution was used as base solution and medical oxygen was introduced into a 'medical hyperoxygenated solution apparatus' (MHSA, Xi'an Medical Equipment Co., China) at an inflow of 3 l/min for 15 min.…”

Section: Preparation Of Hosmentioning

confidence: 99%

“…A photochemical technique is used to dissolve oxygen in commercially available medical solutions such as normal saline or Ringer's solution, converting them into HOSs with an oxygen pressure (pO 2 ) as high as 100-120 kPa, and a pO 2 up to ten times higher than that in arterial blood [6] . The administration of HOS in animal experiments has been proved to preserve organ function and integrity after ischemia-reperfusion injury of the myocardium, spinal cord, intestine and brain [5][6][7][8][9][10] . In this study, intraluminal HOS infusion was applied to rabbits to evaluate the effect of HOS on oleic acid induced ALI, in order to expand our repertoire of therapeutic measures in patients suffering hypoxia.…”

mentioning

confidence: 99%

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Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Li²,

Feng³

et al. 2008

Eur Surg Res

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Background/Aims: Hyperoxygenated solution (HOS) has been shown to protect the myocardium, spinal cord and brain from ischemic injury. In this study, we evaluated the effect of HOS on acute lung injury (ALI) induced by oleic acid in rabbits. Methods: 24 rabbits were randomized into four groups: control (C), oleic acid (OA), inhaled oxygen (OX), and HOS treatment (HOS). The ALI model was produced by administrating oleic acid intravenously. Half an hour after oleic acid infusion, animals received inhaled oxygen at 30% FiO₂ or 20 ml/kg HOS intravenously. Various parameters were measured during the 2 h after oleic acid treatment. Results: After treatment with oleic acid, mean arterial pressure and PaO₂ decreased significantly compared to group C (p < 0.01), while lung/body ratio, lung water content, and the levels of myeloperoxidase (MPO) and TNF-α in the serum and BALF increased significantly (p < 0.01). Histologically, interstitial edema, alveoli exudation and massive inflammatory cell infiltration were observed in the lung. However, when treated with 20 ml/kg HOS, PaO₂ significantly increased compared to group OA (p < 0.05). The MPO and TNF-α levels in the serum and BALF were decreased (p < 0.01), pulmonary edema was reduced (p < 0.01). Improved pathological manifestations were observed. Conclusion: HOS at 20 ml/kg has therapeutic effects to ameliorate the biological and morphological changes to the lung induced by oleic acid. HOS is a safe, simple and effective measure to protect animals from ALI.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Hosmentioning

confidence: 99%

mentioning

confidence: 99%

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Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Li²,

Feng³

et al. 2008

Eur Surg Res

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“…[24] Furthermore, intestinal I/R triggers accumulation of cytokines, platelet activating factor, IL-1β, IL-6 and NO. [25,26] Previous studies [27,28] found mitochondrial damage in the intestinal I/R model, confirming that impaired intestinal mitochondria result in morphological changes and changes of respiratory function. The administration of oxygen saturated solution to the intestine may partially restore mitochondrial function.…”

Section: Discussionmentioning

confidence: 57%

Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats

Zhou¹,

Sun²,

Wang³

2012

World Journal of Emergency Medicine

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“…As a means of oxygen delivery, HOS offers several advantages for some ischemic disorders [5,6,13]. Since oxygen contained in HOS is physically dissolved and the concentration varies linearly with oxygen pressure, HOS will release oxygen by a passive diffusion process whenever an oxygen pressure gradient exits.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Intravenous Hyperoxygenated Solution Infusion on Systemic Oxygenation and Intrapulmonary Shunt During One-Lung Ventilation in Pigs

Gao

Zhang

Sun

et al. 2010

Journal of Surgical Research

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Amelioration of Intestinal Ischemia–Reperfusion Injury with Intraluminal Hyperoxygenated Solution: Studies on Structural and Functional Changes of Enterocyte Mitochondria1

Cited by 27 publications

References 32 publications

Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats

The Effects of Intravenous Hyperoxygenated Solution Infusion on Systemic Oxygenation and Intrapulmonary Shunt During One-Lung Ventilation in Pigs

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