Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

Chanvitayapongs, Songsiri; Draczynska-Lusiak, B; Sun, Albert Y.

doi:10.1097/00001756-199704140-00035

Cited by 193 publications

(94 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, resveratrol was found to be a highly potent antioxidant which could inhibit free radical generation in brain, spinal cord, kidney, liver and red cell membrane [35][36][37][38] . It has been shown that resveratrol inhibits lipid peroxidation [39] , and prevents apoptotic cell death induced by oxidative stress [40] . The end production of lipid peroxidation includes aldehydes, hydrocarbon gases, and MDA.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Gedik¹,

Gırgın²,

Öztürk³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 µmol/L, iv). Liver tissues were obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratroltreated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Gedik¹,

Gırgın²,

Öztürk³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…Recently, resveratrol was found to be a highly potent antioxidant that could inhibit free radical generation in the brain, spinal cord, heart, kidney, liver, red cell membrane, and so on [19,36,[44][45][46][47][48][49] . It has been shown that it inhibits lipid peroxidation [50] , and prevents apoptotic cell death induced by oxidative stress [51,52] . It has been postulated that resveratrol could supress mitochondria-induced production of ROS in rat brain [53] , protect DNA from oxidative damage in stroke-prone hypertensive rats [54] , and could inhibit neuronal loss after ischemia/reperfusion injury in gerbils [44] .…”

Section: Discussionmentioning

confidence: 99%

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury

Ateş

Çaylı

Altınöz

et al. 2006

Acta Pharmacologica Sinica

View full text Add to dashboard Cite

Aim: To investigate the neuroprotective effect of resveratrol in an experimental spinal cord injury (SCI) model in rats. Methods: Male Wistar albino rats weighing 200-250 g were randomized into six groups. Weight-drop trauma was performed for SCI. Group 1 underwent laminectomy alone. Group 2 underwent laminectomy followed by SCI. Groups 3, 4, 5, and 6 underwent laminectomy followed by SCI and received resveratrol (100 mg/kg), methylprednisolone (MP) (30 mg/kg), resveratrol (100 mg/kg) plus MP (30 mg/kg), and ethanol (2%), respectively. The rats were divided into two subgroups for biochemical analysis (killed at 24 h after surgery) and for neurobehavioral and histopathological evaluation (killed at 6 weeks after surgery). Posttraumatic neurological recovery after surgery was recorded weekly. Results: Groups 3 and 5 revealed significantly lower malondialdehyde, nitric oxide, xanthine oxidase, and higher glutathione levels than group 4 (P<0.05). Neurological recovery rates were significantly better in groups 3 and 5 than group 4 (P<0.05). When spinal trauma size ratios were compared, there was no significant difference between treatment groups. Conclusion: Resveratrol treatment revealed better biochemical recovery in the acute stage of trauma than MP treatment. Although resveratrol and combined treatment revealed better neurobehavioral recovery than MP treatment; resveratrol, MP, and combined treatment modalities improved histopathological recovery at the same level in the final stage of the experiment. Future studies involving different doses of resveratrol and different doses combinations with MP could promise better results as each drug has a different anti-oxidative mechanism of action.

show abstract

“…Later on, trans-resveratrol was found to be the most effective extract from grape skin and seed, as well as a variety of other plants such as peanuts and berries, that produces beneficial health effects. To assess its role as an antioxidant, resveratrol was compared with the classical antioxidative vitamins C and E in a 1977 study (Chanvitayapongs et al, 1997). In this study, oxidative stress was induced by addition of Fe2+ and t-butyl hydroperoxide to the cultured PC12 cell medium.…”

Section: Resveratrolmentioning

confidence: 99%

The Serotonergic System and Neuroplasticity are Implicated in the Effect of Phytochemicals on Mood and Cognitive Disorders

Xu¹,

Zhang²,

Ogle³

2012

Recent Advances in Theories and Practice of Chinese Medicine

View full text Add to dashboard Cite

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

Cited by 193 publications

References 6 publications

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury

The Serotonergic System and Neuroplasticity are Implicated in the Effect of Phytochemicals on Mood and Cognitive Disorders

Contact Info

Product

Resources

About