2010
DOI: 10.1016/j.etap.2010.04.001
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Ameliorative effect of curcumin on hepatotoxicity induced by chloroquine phosphate

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Cited by 34 publications
(22 citation statements)
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“…The high MDA concentrations of the pituitary and the testicular tissues in the CPF group are indications of the level of lipoperoxidative changes, reflecting alteration in structural and perhaps functional status of these organs. Lipid peroxidation involves the formation and propagation of lipid radicals, the uptake of oxygen and rearrangement of the double and unsaturated lipids, resulting in a variety of degraded products that eventually cause destruction of membrane lipids [37] . However, pretreatment with melatonin has been shown by the present study to decrease the testicular and pituitary MDA concentrations, indicating its anti-lipoperoxidative effect.…”
Section: Discussionmentioning
confidence: 99%
“…The high MDA concentrations of the pituitary and the testicular tissues in the CPF group are indications of the level of lipoperoxidative changes, reflecting alteration in structural and perhaps functional status of these organs. Lipid peroxidation involves the formation and propagation of lipid radicals, the uptake of oxygen and rearrangement of the double and unsaturated lipids, resulting in a variety of degraded products that eventually cause destruction of membrane lipids [37] . However, pretreatment with melatonin has been shown by the present study to decrease the testicular and pituitary MDA concentrations, indicating its anti-lipoperoxidative effect.…”
Section: Discussionmentioning
confidence: 99%
“…The administration of curcumin, an herbal antioxidant obtained from Curcuma longa , prevented hepatotoxicity in rats treated with chloroquine [154]. Likewise, the administration of glutathione promoted reduced parasitemia and increased survival of mice infected with P. berghei [155].…”
Section: Potential Benefit Of Adjuvant Antioxidant Therapy For Malmentioning
confidence: 99%
“…Curcumin/tetrahydrocurcumin (THC) exhibits a wide range of pharmacological activities, including anti‐oxidant, anti‐toxic, anti‐inflammatory, and having potentially chemotherapeutic properties (Anand et al, ; Tyagi et al, ). The use of THC has been reported as a therapeutic agent to mitigate various kinds of toxicity including cardiotoxicity (Swamy, Gulliaya, Thippeswamy, Koti, & Manjula, ), nephrotoxicity (Ueki, Ueno, Morishita, & Maekawa, ), hepatotoxicity (Dattani et al, ), and neurotoxicity (Sharma, Suhalka, Sukhwal, Jaiswal, & Bhatnagar, ). Treatment with THC was found to modulate mitochondrial dysfunction and its property as an antioxidant and widely thought to be responsible for its protective effects in mitochondria (Zhu et al, ).…”
Section: Introductionmentioning
confidence: 99%