Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Li, Xican; Wang, Li; Han, Weijuan; Mai, Wenqiong; Han, Lu; Chen, Dong Feng

doi:10.5505/tjb.2014.65882

Cited by 24 publications

(13 citation statements)

References 40 publications

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“…The IC 50 values of amentoflavone were 31.85 ± 4.75, 198.75 ± 33.53, 147.14 ± 20.95, 75.15 ± 10.52, 93.75 ± 16.36, 167.69 ± 13.90, and 137.95 ± 19.86 μM, respectively, for DNA, cytosine, uracil, adenine, thymine, guanine, and deoxyribose damage. Radical-scavenging assays indicated that amentoflavone could effectively scavenge center dot O 2− , DPPH, ABTS + radicals with IC 50 values of 8.98 ± 0.23, 432.25 ± 84.05, 7.25 ± 0.35 μM, respectively [ 166 ].…”

Section: Pharmacologymentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.

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Section: Pharmacologymentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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“…Antioxidant supplement has been determined to have protective influences on the treatment of sepsis 10 and nowadays, antioxidants obtained from natural foods have drawn special attention 11 . Extreme free radicals and lipid peroxidation products cause harms in the mitochondria and cell membranes, finally leading to cell necrosis and apoptosis 7 .…”

Section: Naturalmentioning

confidence: 99%

Alpha-lipoic acid alleviates lipopolysaccharide-induced liver damage in rats via antioxidant effect

Çimen¹,

Çimen²,

Çetin³

et al. 2019

Dicle Tıp Dergisi

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Objective: The effect of lipoic acid (LA), which is considered to be a potential antioxidant, on oxidative stress parameters in liver tissue damage has not been sufficiently investigated. Therefore, we aimed to investigate the relationship of LA with oxidant and antioxidant parameters in lipopolysaccharide (LPS) induced liver damage in rats. Results: It was found that 3-NT and MDA levels were significantly lower in LA+LPS group than those of LPS group. Moreover, it was found that antioxidant enzyme activity values of LA+LPS approached to the values of control group. Conclusion: These findings indicate that the oxidant/antioxidant status is balanced in the LA group. Therefore, it may be suggested that LA supplementation to be beneficial for preventing oxidative stress in LPS-induced liver damage in rats.

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“…Amentoflavone (6) possesses a wide variety of bioactivities, such as antiphotoaging [ 75 ], antifungal [ 76 ], antimicrobial [ 77 ], antioxidant [ 78 ], anti-inflammatory [ 79 ], antidiabetic [ 80 ], antipsoriasis [ 81 ], diuretic [ 82 ] and antitumor [ 83 , 84 ], as well as neuroprotective [ 85 ] and osteogenesis effects [ 86 ], and it confers cardiovascular injury protection [ 87 ]. Although all these bioactivities are well reviewed with great detail by Yu et al [ 74 ] there are still some studies that are worth mentioning that were not included in the review.…”

Section: Bioactive Secondary Metabolites From Juniperus mentioning

confidence: 99%

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

Tavares

Seca

2018

Medicines

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Background: Plants and their derived natural compounds possess various biological and therapeutic properties, which turns them into an increasing topic of interest and research. Juniperus genus is diverse in species, with several traditional medicines reported, and rich in natural compounds with potential for development of new drugs. Methods: The research for this review were based in the Scopus and Web of Science databases using terms combining Juniperus, secondary metabolites names, and biological activities. This is not an exhaustive review of Juniperus compounds with biological activities, but rather a critical selection taking into account the following criteria: (i) studies involving the most recent methodologies for quantitative evaluation of biological activities; and (ii) the compounds with the highest number of studies published in the last four years. Results: From Juniperus species, several diterpenes, flavonoids, and one lignan were emphasized taking into account their level of activity against several targets. Antitumor activity is by far the most studied, being followed by antibacterial and antiviral activities. Deoxypodophyllotoxin and one dehydroabietic acid derivative appears to be the most promising lead compounds. Conclusions: This review demonstrates the Juniperus species value as a source of secondary metabolites with relevant pharmaceutical potential.

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Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Cited by 24 publications

References 40 publications

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Alpha-lipoic acid alleviates lipopolysaccharide-induced liver damage in rats via antioxidant effect

The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites

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