Aminoglycoside-containing antibiotic combinations for the treatment of bacterial endocarditis: an evidence-based approach

Leibovici, Leonard

doi:10.1016/j.ijantimicag.2010.11.006

Cited by 12 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have specifically explored the nephrotoxic effects of aminoglycosides in patients with IE and observed that worsening of renal function correlated with the duration of gentamicin treatment [31]. Pooling together the results of four randomized controlled trials that included patients with IE, the relative risk of nephrotoxicity was 2.22 (95% CI 1.11, 4.35) in patients treated with aminoglycosides [32]. Consistently, in a recent randomized controlled trial, Fowler et al .…”

Section: Discussionmentioning

confidence: 84%

Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

et al. 2013

View full text Add to dashboard Cite

IntroductionCardiac surgery is frequently needed in patients with infective endocarditis (IE). Acute kidney injury (AKI) often complicates IE and is associated with poor outcomes. The purpose of the study was to determine the risk factors for post-operative AKI in patients operated on for IE.MethodsA retrospective, non-interventional study of prospectively collected data (2000–2010) included patients with IE and cardiac surgery with cardio-pulmonary bypass. The primary outcome was post-operative AKI, defined as the development of AKI or progression of AKI based on the acute kidney injury network (AKIN) definition. We used ensemble machine learning (“Super Learning”) to develop a predictor of AKI based on potential risk factors, and evaluated its performance using V-fold cross validation. We identified clinically important predictors among a set of risk factors using Targeted Maximum Likelihood Estimation.Results202 patients were included, of which 120 (59%) experienced a post-operative AKI. 65 (32.2%) patients presented an AKI before surgery while 91 (45%) presented a progression of AKI in the post-operative period. 20 patients (9.9%) required a renal replacement therapy during the post-operative ICU stay and 30 (14.8%) died during their hospital stay. The following variables were found to be significantly associated with renal function impairment, after adjustment for other risk factors: multiple surgery (OR: 4.16, 95% CI: 2.98-5.80, p<0.001), pre-operative anemia (OR: 1.89, 95% CI: 1.34-2.66, p<0.001), transfusion requirement during surgery (OR: 2.38, 95% CI: 1.55-3.63, p<0.001), and the use of vancomycin (OR: 2.63, 95% CI: 2.07-3.34, p<0.001), aminoglycosides (OR: 1.44, 95% CI: 1.13-1.83, p=0.004) or contrast iodine (OR: 1.70, 95% CI: 1.37-2.12, p<0.001). Post-operative but not pre-operative AKI was associated with hospital mortality.ConclusionsPost-operative AKI following cardiopulmonary bypass for IE results from additive hits to the kidney. We identified several potentially modifiable risk factors such as treatment with vancomycin or aminoglycosides or pre-operative anemia.

show abstract

Section: Discussionmentioning

confidence: 84%

Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Aminoglycosides are frequently used, in addition to β ‐lactams, for the treatment of severe enterococcal infections such as endocarditis or sepsis, among others . Nevertheless, the expression of aminoglycoside‐modifying enzymes can cause high‐level aminoglycoside resistance, that precludes the synergistic effect of aminoglycosides and β ‐lactams, which could cause important therapeutic problems .…”

Section: Introductionmentioning

confidence: 99%

Prevalence, antimicrobial resistance and genetic lineages of Enterococcus spp. from vegetable food, soil and irrigation water in farm environments in Tunisia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The therapy duration is often four to six weeks for native valve endocarditis and longer than six weeks for prosthetic valve endocarditis. [3,86,140,246,247] Is oral antibiotic therapy feasible to use in the treatment of left-sided endocarditis?…”

Section: Antimicrobial Treatment Of Iementioning

confidence: 99%

Consensus Report on Diagnosis, Treatment and Prevention of Infective Endocarditis by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Clinical Microbiology and Infectious Diseases (KLIMIK), Turkish Society of Cardiology (TSC), Turkish Society of Nuclear Medicine (TSNM), Turkish Society of Radiology (TSR), Turkish Dental Association (TDA) and Federation of Turkish Pathology Societies (TURKPATH) Cardiovascular System Study Group

Şimşek-Yavuz

Akar

Aydoğdu

et al. 2020

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

show abstract

Aminoglycoside-containing antibiotic combinations for the treatment of bacterial endocarditis: an evidence-based approach

Cited by 12 publications

References 15 publications

Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study

Prevalence, antimicrobial resistance and genetic lineages of Enterococcus spp. from vegetable food, soil and irrigation water in farm environments in Tunisia

Contact Info

Product

Resources

About