An association of vertebral breast cancer metastasis and multiple myeloma, revealed by a spinal cord compression

Abstract

Authors describe the case of a patient with breast cancer and multiple myeloma as the second metachronous disease responsible for spinal cord compression. Synchronous occurrence of bone marrow breast cancer disease and multiple myeloma has not been described in the literature, as in this case. By presenting this case, we point to possible association between both diseases and the possible factors involved in the development of second malignant disease.

Metachronous infiltration of bone marrow due to breast cancer and multiple myeloma

“…Sakai et al [11] reported an association between multiple myeloma with clear cell renal carcinoma and emphasized the possible role of growth factors like IL-6. Kherfani et al [12] reported a synchronous hormone receptor-positive breast cancer and multiple myeloma case with the involvement of thoracic and lumbar spinal cord. Sehgal et al [13] reported a case of prostate adenocarcinoma and multiple myeloma with synchronous infiltration of bone marrow.…”

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

“…The distinction may be challenging by cytomorphology alone [ 17 ]. Kherfani et al reported a case of spinal cord compression from concurrent multiple myeloma and metastatic breast cancer in the same vertebra [ 18 ]. Al-Said Ali et al reported synchronous diagnosis of multiple myeloma and breast cancer on initial presentation similar to our case in 2009 [ 19 ].…”

Secondary Bone Marrow Malignancies after Adjuvant Chemotherapy for Breast Cancer: A Report of 2 Cases and a Review of the Literature

“…Nevertheless, there are a number of reports describing the relationship between anthracyclines and increased risk of acute myeloid leukemia in women with breast cancer (4, 5). In addition, by a PubMed search, we found few reports concerning patients with multiple myeloma mimicking bone metastases of breast cancer (6, 7) or association of vertebral breast cancer metastasis and multiple myeloma (8).…”