Understanding youths' emotional/behavioral problems is a challenge to mental health professional. Within assessment methods, one of the most used is empirically based assessment, on which syndromes are elaborated based on statistical analyzes of cooccurrence of problems based on epidemiological researches. The Achenbach System of Empirically Based Assessment (ASEBA) provides the Youth Self-Report (YSR) as a tool to access adolescents' problems. On this form, youths give information regarding their competences and emotional/behavioral problems. Several studies have been conducted in order to validate the YSR on different countries, considering the importance of standardization of the assessment procedures for the culture where they will be used. The aim of this study was to validate the Youth Self-Report (YSR) for assessing Brazilian youths. A total of 540 referred and 2886 non-referred youths, aged 11 to 18 years old, from four of the five regions of Brazil, filled out the form. Socioeconomic data were also collected. Results indicate good model fit indexes for the Brazilian population (RMSEA = 0.032), internal consistency and discriminate capacity for the problems scales. Less expressive results were found for the competence scales. Sex and age differences followed the patters established by studies from several societies. Country region and socioeconomic had low impact on the results. Taken together, the results indicate the validity and reliability of the YSR for the Brazilian population, and indicate the appropriate norms for the use of the questionnaire in this country.